Pulmonary Cell News 7.39 October 4, 2018 | |
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TOP STORYReprogramming Normal Human Epithelial Tissues to a Common, Lethal Neuroendocrine Cancer Lineage Researchers demonstrated that a common set of defined oncogenic drivers reproducibly reprogrammed normal human prostate and lung epithelial cells to small cell prostate cancer and small cell lung cancer, respectively. [Science] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Functional analysis revealed that plasmacytoid dendritic cells (PDCs) co-cultured with primary bronchial epithelial cells (PBECs) displayed upregulation of type I IFN production and response genes. Scientists observed increased secretion of type I IFN and other cytokines in response to influenza in PDCs co-cultured with PBECs. The PDCs also primed Th1 responses in T cells. [Mucosal Immunol] Abstract Exosomal 15-LO2 Mediates Hypoxia-Induced Pulmonary Artery Hypertension In Vivo and In Vitro In vitro, 15-LO2 was abundantly expressed and enriched in exosomes secreted from hypoxic pulmonary artery endothelial cells (PAECs), which subsequently activated the STAT3 signaling pathway, resulting in a robust increase in PAECs proliferation. [Cell Death Dis] Full Article S100A8 Protects Human Primary Alveolar Type II Cells Against Injury and Emphysema Scientists used freshly isolated ATII cells from non-smoker and smoker organ donors, as well as emphysema patients to determine S100A8 function. S100A8 protein and mRNA levels were low in individuals with this disease and correlated with its severity as determined by using lung tissue from areas with mild and severe emphysema obtained from the same patient. [Am J Respir Cell Mol Biol] Abstract Baseline levels of IL-6 and IL-8 were significantly higher in primary bronchial epithelial cells isolated from COPD lung donors than in non-COPD PBECs. Upon recombinant human Hsp70 stimulation, IL-6 and IL-8 were significantly increased, with the strongest response in COPD-derived PBECs. [Biochimie] Abstract LUNG CANCERIL-6 expression was significantly decreased in USP24-knockdown M2 macrophages and lung cancer cells, and IL-6-replenished conditioned medium restored the migratory, chemotactic and angiogenetic properties of the cells. [Nat Commun] Full Article CircPTK2 and transcriptional intermediary factor 1 γ (TIF1γ) were significantly down-regulated in NSCLC cells undergoing epithelial-mesenchymal transition (EMT) induced by TGF-β. CircPTK2 overexpression augmented TIF1γ expression, inhibited TGF-β-induced EMT and NSCLC cell invasion, whereas circPTK2 knockdown had the opposite effects. [Mol Cancer] Full Article Using NSCLC as a model system, researchers showed that 1,2:5,6-Dianhydrogalactitol (DAG)-induced cytotoxicity materialized when cells entered S phase with unrepaired N7-guanine DNA crosslinks. In S phase, DAG-mediated DNA crosslink lesions translated into replication-dependent DNA double-strand breaks that subsequently triggered irreversible cell cycle arrest and loss of viability. [Cell Death Dis] Full Article MARCH9 Suppresses Lung Adenocarcinoma Progression by Downregulating ICAM-1 Investigators demonstrated that membrane-associated RING-CH protein 9 (MARCH9) could attenuate tumor migration and invasion but had little effect on cell cycle or apoptosis. An interaction between MARCH9 and ICAM-1 protein was identified, and overexpression of MARCH9 was found to attenuate the oncogenic effect of ICAM-1, suggesting that MARCH9 may inhibit tumor progression by downregulating ICAM-1 signaling. [Cell Physiol Biochem] Full Article Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) could activate interferon regulatory factor (IRF)7, the retinoid-inducible protein (RIG)-I-like receptor signaling pathway and Bcl-2 in vitro. Over-expression of AFAP1-AS1 promoted NSCLC cell proliferation, invasion and migration while inhibiting cell apoptosis. [Cell Physiol Biochem] Full Article Researchers observed that the dynamin inhibitor dynasore effectively suppressed the exon 19-deleted mutant of EGFR. This agent inhibited cell proliferation, colony formation, cell migration, and cell cycle progression of HCC827 and H1650 cells driven by the exon 19-deleted EGFR mutant. Dynasore suppressed the activation of AKT and MEK in HCC827 and H1650 cells. [Int J Biochem Cell Biol] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSUse of 3D Organoids and Lung-on-a-Chip Methods to Study Lung Development, Regeneration and Disease The authors focus on the respiratory system and provide an overview of in vitro models which can be derived from primary lung cells, pluripotent stem cells, as well as healthy or diseased lungs. They emphasize their potential application in studies of respiratory development, regeneration and disease modeling. [Eur Respir J] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSThe U.S. FDA approved a new drug, Arikayce, for the treatment of lung disease caused by a group of bacteria, Mycobacterium avium complex in a limited population of patients with the disease who do not respond to conventional treatment. [U.S. Food and Drug Administration] Press Release Innovent Biologics, Inc. announced that the first patient has been dosed in a Phase III clinical trial studying sintilimab, a fully human anti-PD-1 monoclonal antibody, as first-line treatment for patients with previously untreated squamous non-small cell lung cancer. [Innovent Biologics, Inc.] Press Release X-Rx, Inc. announced that it has completed IND-enabling studies with X-165, a potent orally available inhibitor of autotaxin, for the treatment of idiopathic pulmonary fibrosis and other fibrotic indications. [X-Rx, Inc.] Press Release QIAGEN Receives FDA Approval to Expand Use of EGFR Test in Lung Cancer QIAGEN N.V. announced that the U.S. FDA has approved a PMA Supplement expanding the labelling claim of the therascreen® EGFR RGQ PCR Kit to allow its use as a companion diagnostic with Pfizer’s VIZIMPRO® for first-line treatment of patients with non-small cell lung cancer with epidermal growth factor receptor (EGFR) exon 19 deletions or an exon 21 L858R mutation. [QIAGEN] Press Release | |
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POLICY NEWSMr Smits Goes to Washington: Architect of Bold European Open-Access Plan Hopes to Garner US Support A month after European funders launched the ‘Plan S’ initiative to demand immediate open access to scientific literature in the next two years, the plan’s creators have revealed more details about their bold scheme — and are hurriedly trying to get support from US policymakers. [Nature News] Editorial Brazil’s Presidential Election Could Savage Its Science A populist surge from a right-wing presidential candidate in Brazil that is threatening to upend the country’s politics could have huge impacts on research budgets and environmental policies. [Nature News] Editorial At NEJM, a Change at the Top Offers a Chance to Reshape the World’s Oldest Medical Journal The retirement of Dr. Jeffrey Drazen as editor of the New England Journal of Medicine has created an opportunity to bring a new perspective to what is arguably the world’s most prestigious medical journal. [STAT News] Editorial
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EVENTSNEW Defence is the Best Attack: Immuno-Oncology Breakthroughs Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Lung Cancer (University of Cambridge) Postdoctoral Fellow – Vascular and/or Lung Biology (Yale University) Postdoctoral Research Fellow – Respiratory Epithelial Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Sepsis and Pulmonary Injury Research (University of Maryland) Faculty Investigators – Cancer Research (The University of Alabama at Birmingham) Postdoctoral Position – Lung Diseases (German Research Center for Environmental Health) Principal Investigators – Cancer (University of Alabama Birmingham) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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