Pulmonary Cell News 7.49 December 13, 2018 | |
| |
TOP STORYResearchers report a role of nuclear protein kinase Cδ (PKCδ) as a common axis across multiple known tyrosine kinase inhibitor (TKI)-resistance mechanisms. They demonstrated that TKI-inactivated epidermal growth factor receptor (EGFR) dimerized with other membrane receptors implicated in TKI resistance to promote PKCδ nuclear translocation. [Cancer Cell] Abstract | Press Release | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the mechanism by which protein arginine methyltransferase-1 (PRMT1) regulates mitochondrial mass in primary human airway wall fibroblasts. Fibroblasts from control or asthma patients were stimulated with TGF-β for up to 48 hours, and the signaling pathways controlling PRMT1 expression and mitochondrial mass were analyzed. [J Immunol] Abstract | Full Article The authors found that interleukin (IL)-37 inhibited the induction of thymic stromal lymphopoietin (TSLP) expression by the main antigen of house dust mite, Der p1, by suppressing NF-κB and extracellular signal regulated kinase 1/2 (ERK1/2) activation in 16-HBE cells in vitro. [Immunol Cell Biol] Abstract miR-627/HMGB1/NF-κB Regulatory Loop Modulates TGF-β1-Induced Pulmonary Fibrosis miR-627 overexpression could partially reverse TGF-β1-induced normal human lung fibroblast proliferation, as well as α-SMA and collagen I protein expression. Moreover, miR-627/high-mobility group box protein 1 (HMGB1) affected TGF-β1 release through RAGE/NF-κB signaling; miR-627/HMGB1 and RAGE/NF-κB signaling formed a regulatory loop to modulate TGF-β1-induced pulmonary fibrosis in vitro. [J Cell Biochem] Abstract LUNG CANCERThe authors created a panel of ERCC1D lung cancer cell lines which they characterized. They observed that loss of ERCC1 hypersensitized cells to cisplatin when wildtype p53 was retained, while there was only modest sensitivity in cell lines that were p53mutant/null. [Clin Cancer Res] Abstract CNOT3 Targets Negative Cell Cycle Regulators in Non-Small Cell Lung Cancer Development Depletion of CNOT3 suppressed proliferation of A549 human non-small cell lung cancer cells with enhanced mRNA stability and subsequent elevated expression of p21. Aberrant up-regulation of Krüppel-like factor 2 by CNOT3 depletion led to impairment in the proliferation of A549 cells. [Oncogene] Abstract Scientists designed and synthesized quinazolin-2,4-one-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6. The most potent and selective compound, 3d substantially increased acetylation of α-tubulin instead of histones in the lung cancer cell line, LL2. [J Med Chem] Abstract Knockdown of circPVT1 suppressed non-small cell lung cancer (NSCLC) cell proliferation, migration and invasion, and increased apoptosis. In addition, circPVT1 mediated NSCLC progression via the regulation of the E2F2 signaling pathway. [Cell Physiol Biochem] Full Article Researchers found that miR-148a-3p acts as a tumor-suppressor in the development and progression of non-small-cell lung cancer (NSCLC). miR-148a-3p inhibited NSCLC cells proliferation and epithelial-mesenchymal transition by reducing the expression of son of sevenless 2, which referred Ras activating. [J Cell Physiol] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
| |
REVIEWSThe Lung Microenvironment: An Important Regulator of Tumor Growth and Metastasis The authors highlight recent advances and emerging concepts for how the tumor-reprogrammed lung microenvironment promotes both primary lung tumors and lung metastasis from extrapulmonary neoplasms by contributing to inflammation, angiogenesis, immune modulation and response to therapies. [Nat Rev Cancer] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
| |
SCIENCE NEWSWindtree Therapeutics, Inc. announced that data from the AEROSURF® Phase II clinical program in premature infants with respiratory distress syndrome (RDS) was presented. [Press release from Windtree Therapeutics, Inc. discussing research presented at the 2018 Hot Topics in Neonatology Annual Meeting, Washington D.C] Press Release | |
| |
INDUSTRY NEWSCBT Pharmaceuticals (CBT), Inc. and Strata Oncology, Inc. announced that the companies have entered into an agreement to drive patient enrollment in CBT’s ongoing Phase I/II trial of CBT-101 in cancer patients with c-Met dysregulated malignancies including non-small cell lung cancer. [CBT Pharmaceuticals, Inc.] Press Release Vertex Pharmaceuticals Incorporated announced that Health Canada has granted Market Authorization for ORKAMBI® to include use in children ages two through five years with CF who have two copies of the F508del CFTR mutation. [Vertex Pharmaceuticals Inc.] Press Release Innovent Biologics, Inc. announced that IBI305, a recombinant humanized anti-VEGF monoclonal antibody being developed as potential biosimilar to Avastin, has met pre-defined primary endpoints in two randomized, head to head, clinical trials comparing IBI305 versus branded bevacizumab: a Phase III clinical trial in patients with advanced non-squamous non-small cell lung cancer and a pharmacokinetic study in healthy subjects. [Innovent Biologics, Inc.] Press Release Aridis Pharmaceuticals announced that the first subject has been enrolled in a Phase I/IIa clinical study evaluating the investigational candidate AR-501 for treatment of chronic bacterial lung infections in patients with CF. [Aridis Pharmaceuticals, Inc.] Press Release Vast Therapeutics, Inc., announced that the company has received an award from Cystic Fibrosis Foundation, to support the continued development of its lead NO-release drug candidate, BIOC51 for the treatment of Pseudomonas aeruginosa in patients with CF. [Vast Therapeutics, Inc. (PR Newswire Association LLC.)] Press Release NCFB, FDA Grants “Fast Track” and QIDP Zambon announced that colistimethate sodium powder for nebulizer solution, delivered by the I-neb AAD system obtained QIDP and Fast Track designation by the FDA for the indication “prevention of pulmonary exacerbations in adult patients with non-cystic fibrosis bronchiectasis (NCFB) colonized with Pseudomonas aeruginosa”. [Zambon Company S.P.A] Press Release New 2-in-1 Powder Aerosol to Upgrade Fight against Deadly Superbugs in Lungs Purdue researchers have invented a drug formulation that uses two synergistic antibiotics – colistin and ciprofloxacin – in one single particle that is shown to reach infection sites in the deep lung area with the capability to kill multi-drug-resistant superbugs. [Purdue University] Press Release | |
| |
POLICY NEWSNIH Report Scrutinizes Role of China in Theft of U.S. Scientific Research Institutions across the U.S. may have fallen victim to a tiny fraction of foreign researchers who worked to feed American intellectual property to their home countries, an advisory committee to the National Institutes of Health (NIH) found in a report. [STAT News] Editorial The End of DACA Would Be a Blow to Science With the end of Deferred Action for Childhood Arrivals (DACA), undocumented scientists will lose what few protections they currently have under immigrant law, lose their access to their scientific research, and once again live in fear, as they are caught in legal limbo. [Scientific America] Editorial
| |
EVENTSNEW 2019 ASCO Annual Meeting Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Assistant Professor – Cancer Biology (Cold Spring Harbor Laboratory) Postdoctoral Position – Asthma Epigenetics & Genomics (La Jolla Institute for Allergy & Immunology) Postdoctoral Researcher – Lung Cancer Research (University of Cologne) Research Associate – Gene Therapy Lung Research (Imperial College of London) Postdoctoral Position – Pulmonary Fibrosis Research (University of California San Francisco) Staff Scientist/ Tier 2 Canada Research Chair – Lung Research (University of Toronto) Faculty Positions – Cancer-Focused Target & Drug Discovery (University of New Mexico) Postdoctoral Research Fellow – Sepsis & Lung Inflammation Pathogenesis Research (Boston University) Associate Professor – Oncology (University of California, Davis) Postdoctoral Scholar – Cancer Metabolism (The Moffitt Cancer Center) Postdoctoral Position – Lung Cancer Biology (UT Southwestern Medical Center) Postdoctoral Research Scientist – Modeling Infection in Human Lung Organoids (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pulmonary Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|