Pulmonary Cell News 8.32 August 22, 2019 | |
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TOP STORYThe authors report on the development of a pulmonary delivery system based on perfluorocarbon (PFC) nanoemulsions for combined delivery of a partially fluorinated polymeric CXCR4 antagonist (FM) and anti-STAT3 siRNA. They prepared FM-stabilized PFC as delivery systems of therapeutic siRNA adsorbed on the surface of the emulsion. [Mol Ther] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists identified cathepsin A as a novel LC3B binding partner and its overexpression in vitro drove MLE12 cells to apoptosis. Additionally, cathepsin A was increased in the alveolar epithelial cell type II of aged LC3B−/− mice and in the lungs of patients with idiopathic pulmonary fibrosis. [FASEB J] Abstract Biomechanical Response of Lung Epithelial Cells to Iron Oxide and Titanium Dioxide Nanoparticles An acute exposure of epithelial pulmonary cells to Fe2O3 and TiO2 nanoparticles, which was mild since it was non-cytotoxic and did not induce inflammation, modified cell biomechanical properties which could be translated into damage of the epithelial barrier integrity. [Front Physiol] Full Article Blockade of EGFR Activation Promotes TNF-Induced Lung Epithelial Cell Apoptosis and Pulmonary Injury Gefitinib, an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), enhanced lung epithelial cell apoptosis and lymphocytic inflammation, indicating that EGFR tyrosine kinase prevented tumor necrosis factor (TNF)-induced lung injury. [Int J Mol Sci] Full Article Researchers developed several mesenchyme-free culture conditions that promoted growth of murine alveolar type-2 (AT2) organoids. Transplanting dissociated AT2 organoids into influenza-infected mice demonstrated that organoids engrafted and either proliferated as AT2 cells or unexpectedly adopted a basal cell-like fate associated with maladaptive regeneration. [NPJ Regen Med] Full Article | Press Release LUNG CANCERResearchers identified important roles of protein kinase Cα (PKCα) in regulating mTORC1 activity in lung cancer cells, whereby a primary switching occurred from PKCα-independent to PKCα-dependent signaling in the presence of epidermal growth factor receptor (EGFR) mutations. [Oncogene] Abstract Both in vitro and in vivo experiments found that the downregulation of circARHGAP10 suppressed glycometabolism by decreasing GLUT1 expression. Silencing circARHGAP10 also suppressed proliferation and metastasis by targeting the miR-150-5p/GLUT1 axis in non-small cell lung cancer, which was confirmed with a luciferase reporter assay. [Mol Ther Nucleic Acids] Abstract | Full Article Investigators reported that vismodegib, an inhibitor of the sonic Hedgehog pathway, only elicited minor antitumor efficacy in A549 and NCI-H1975 lung adenocarcinoma cells as well as in xenograft tumors, with overexpressed GLI2 and increased autophagic activity. [Cell Death Dis] Full Article The authors delineated that KRAS-mutant lung cancer cells resistant to pemetrexed and anti-MEK drug trametinib acquired an exquisite dependency on endoplasmic reticulum stress signaling, rendering resistant cancer cells selectively susceptible to blockage of HSP90, the receptor tyrosine kinase AXL, the eukaryotic translation initiation factor 4E (eIF4E), and the unfolded protein response. [Oncogenesis] Abstract To facilitate future clinical application of BCT-100 in small cell lung cancer (SCLC) treatment, scientists elucidated the potential mechanisms that underlie acquired drug resistance to BCT-100. H446 and H526 SCLC cells were serially cultured in stepwise increasing concentrations of BCT-100 until stable BCT-100-resistant cell lines emerged. [Sci Rep] Full Article Researchers showed that combined, but not single, gene transfer resulted in markedly reduced proliferation and increased cell death correlated with reduced levels of phosphorylated pRB, induction of CDKN1A and caspase 3 activity, yet avoiding the induction of senescence. [Gene Ther] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSRelevance Function of MicroRNA-708 in the Pathogenesis of Cancer Investigators highlight the association between miR-708 and several cancers and focus on the recent studies of miR-708 regulation, discussing its potential as an epigenetic biomarker and therapeutic target for these cancers. [Cell Signal] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSVisionGate, Inc. announced that it has finalized an exclusive worldwide license agreement regarding iloprost betadex clathrate and a manufacturing and supply agreement for the substance iloprost with Bayer AG in the field of lung cancer and lung cancer prevention. [VisionGate, Inc. (GlobeNewswire, Inc.)] Press Release Aqualung was awarded an NIH FASTTRACK R41/42 award to support mid and late stage development of a novel therapeutic, eNamptor™ mAb, for patients with acute respiratory failure due to trauma and infection. [Aqualung Therapeutics, Corp.] Press Release The FDA approved Genentech’s Rozlytrek™ for the treatment of adults with ROS1-positive, metastatic non-small cell lung cancer. [Genentech, Inc.] Press Release Vertex Pharmaceuticals Incorporated announced the FDA accepted its New Drug Application (NDA) for the VX-445, tezacaftor and ivacaftor triple combination regimen. [Vertex Pharmaceuticals Incorporated] Press Release | |
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POLICY NEWSMore Than 700 German Research Institutions Strike Open-Access Deal with Springer Nature A consortium of more than 700 German research institutions and libraries announced an agreement with publisher Springer Nature to make it simpler for authors to publish their papers open access. The agreement is the largest national open-access deal to date, but it doesn’t allow authors to publish open access in Nature or its sister journals. [ScienceInsider] Editorial Huge US Government Study to Offer Genetic Counseling A US government study that aims to sequence the genomes of one million volunteers will partner with a genetic-counselling company to help participants understand their results. It will be the largest US government study to provide such a service. [Nature News] Editorial As Brexit Nears, Britain’s Drugs, Devices and Pricing Regulators Seek the Exit Firm details on exactly how the UK will regulate new medicines is still to be decided after it leaves the EU later this year (caveats on timing abound), but we now know that the regulator won’t be run by Dr. Ian Hudson, who is stepping down after six years in charge. [FierceBiotech] Editorial
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EVENTSNEW Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Associate Director – Pulmonary Biology (Translate Bio, Inc.) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Scientist – Pulmonary (STEMCELL Technologies Inc.) Postdoctoral Fellow – Lung-on-Chip Modeling (University of Bern) Postdoctoral Research Fellow – Lung Cancer (University Hospital of Cologne) Postdoctoral Research Fellow – Lung Cancer Immunology (Memorial Sloan Kettering Cancer Center) Assistant/Associate Professor – Respiratory Tract Infections (Hannover Medical School) Postdoctoral Fellowship – Lung Epithelium (Boston University) Postdoctoral Positions – Pulmonary Injury (University of Maryland) PhD Studentship – Extracellular Vesicles in Pulmonary Fibrosis (Université de Franche-Comté) Postdoctoral Researcher – Lung Lineage Development (Hospital for Sick Children) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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