Pulmonary Cell News 8.34 September 5, 2019 | |
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TOP STORYPatient-Derived Lung Cancer Organoids as In Vitro Cancer Models for Therapeutic Screening Investigators report lung cancer organoids and normal bronchial organoids established from patient tissues comprising five histological subtypes of lung cancer and non-neoplastic bronchial mucosa as in vitro models representing individual patients. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors showed that carbon nanotubes caused mitochondrial dysfunction that led to mitophagy in exposed bronchial epithelial cells via a mechanism unrelated to its reported genotoxicity. [Nanotoxicology] Abstract The Effect of Cysteine Oxidation on DJ-1 Cytoprotective Function in Human Alveolar Type II Cells Scientists found that very high oxidative stress in alveolar type II cells in emphysema patients induced DJ-1 overoxidation to the Cys106-SO3− form, leading to increased protein flexibility and loss of its cytoprotective function. [Cell Death Dis] Full Article Acute cigarette smoke condensate exposure reversibly inhibited the phosphorylated cystic fibrosis transmembrane conductance regulator (CFTR) both in vivo and in phospholipid bilayers, without altering its cell surface density and phospho-occupancy. [Sci Rep] Full Article Scientists investigated the relationship between abnormal alveolar micromechanics, alveolar epithelial injury, intra-alveolar fluid properties and remodeling in the conditional surfactant protein B knockout mouse model. [Int J Mol Sci] Full Article LUNG CANCERResearchers found that long intergenic nonprotein coding RNA 173 (Linc00173) was highly expressed in small-cell lung cancer (SCLC) chemoresistant cell lines, and promoted SCLC cells chemoresistance, proliferation, and migration-invasion. [Oncogene] Abstract Knockdown of prion protein expression in cultured lung adenocarcinoma cells decreased their lamellipodium formation, in vitro migration and invasion, and in vivo experimental lung metastasis. [Oncogene] Abstract Olaparib induced phosphorylation of DNA damage markers and reversible G2 arrest in ataxia-telangiectasia mutated-deficient cells, while the combination of olaparib and VE-821 induced cell death. [Br J Cancer] Abstract Investigators uncovered the oncogenic characteristics of ephrin receptor A2 (EPHA2) mutations in squamous cell carcinoma and malignant pleural mesothelioma reinstating the dynamics of different roles of EPHA2 in cancer. [Oncogenesis] Abstract Therapeutic Effect of pHLIP-mediated CEACAM6 Gene Silencing in Lung Adenocarcinoma A549 cells incubated with pH-induced transmembrane structure (pHLIP)-siRNA targeting carcinoembryonic antigen-related cell adhesion molecule 6 (siCEACAM6) at an acidic pH showed downregulated expression of endogenous CEACAM6 protein and reduced cell viability. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSApplication of iPSC to Modeling of Respiratory Diseases Directed differentiation of induced pluripotent cells (iPSCs) toward lung presented the initial challenge to overcome in generating iPSC-derived lung epithelial cells. Since then major advances have been made in defining protocols to specify and isolate specific lung lineages, with the generation of airway spheroids and multi cellular organoids now possible. [Adv Exp Med Biol] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSAridis Pharmaceuticals, Inc. announced results from the company’s first-in-patient Phase II clinical trial evaluating AR-105, a fully human IgG1 monoclonal antibody for the treatment of ventilator-associated pneumonia caused by gram-negative P. aeruginosa. [Aridis Pharmaceuticals, Inc.] Press Release Inhibrx, Inc. announced the enrollment of the first patient in a Phase I clinical trial of INBRX-101. INBRX-101 is an Fc-fusion protein-based therapeutic candidate comprised of a modified recombinant version of human alpha-1 antitrypsin (AAT) for the treatment of patients with AAT deficiency. [Inhibrx, Inc.] Press Release Gala Therapeutics Receives CE Mark for its Minimally Invasive RheOx™ System for Chronic Bronchitis Gala Therapeutics, Inc. announced that its RheOx™ system has received CE Mark in the European Union. In a minimally invasive procedure called Bronchial Rheoplasty™, RheOx delivers non-thermal energy to the airways to reduce mucus-producing cells in patients with chronic bronchitis. [Gala Therapeutics, Inc. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSWorld Health Organization Backs Open-Access Plan S The World Health Organization is joining cOAlition S, a growing group of agencies and charities that fund scientific research and that require their grantees to share their work in open-access journals or repositories. [The Scientist] Editorial A new White House directive laying out next year’s spending priorities for federal research agencies describes a US science enterprise imperiled by internal problems and foreign governments. [ScienceInsider] Editorial UK Science Minister Jo Johnson Resigns Amid Brexit Drama UK science minister Jo Johnson has resigned from his position as universities and science minister and as a member of the House of Commons, citing conflicts between what he thinks is best for the country and family ties. [Nature News] Editorial
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EVENTSNEW Cell Death in Immunity and Inflamation Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Small Cell Lung Cancer (Fred Hutchinson Cancer Research Center) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Scientist – Pulmonary (STEMCELL Technologies Inc.) Postdoctoral Position – Lung Inflammation (The Boston University Pulmonary Center) Postdoctoral Scientist – Small Cell Lung Cancer (Cancer Research UK Manchester Institute) Associate Director – Pulmonary Biology (Translate Bio, Inc.) Postdoctoral Research Fellow – Lung Cancer (University Hospital of Cologne) Postdoctoral Research Fellow – Lung Cancer Immunology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellowship – Lung Epithelium (Boston University) Postdoctoral Positions – Pulmonary Injury (University of Maryland) Postdoctoral Researcher – Lung Lineage Development (Hospital for Sick Children) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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