Pulmonary Cell News Volume 9.01 | Jan 16 2020

TOP STORY

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Blockade of ERK1/2 reactivation following epidermal growth factor receptor tyrosine kinase inhibitor treatment by combined epidermal growth factor receptor/MEK inhibition uncovered cells that survived by entering a senescence-like dormant state characterized by high YAP/TEAD activity. [Cancer Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Enhancement of FAK Alleviates Ventilator-Induced Alveolar Epithelial Cell Injury

Mouse alveolar epithelial cells were cultured in vitro, and focal adhesion kinase (FAK) expression in cells under stretch was investigated. The effects of FAK on cell proliferation, migration and apoptosis were investigated. [Sci Rep] Full Article

Soluble CD93 in Allergic Asthma

Investigators conducted house dust mite stimulation with Der p 1 in BEAS-2B and U937 cells, followed by treatment with dexamethasone or small interfering RNA against CD93. [Sci Rep] Full Article

LUNG CANCER

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Scientists single-cell RNA-sequenced 56,771 endothelial cells from human/mouse-tumoral lung and cultured human lung tumor endothelial cells, and detected 17 known and 16 previously unrecognized phenotypes, including tumor endothelial cells putatively regulating immune surveillance. [Cancer Cell] Abstract | Graphical Abstract

α5-nAChR Contributes to Epithelial-Mesenchymal Transition and Metastasis by Regulating Jab1/Csn5 Signalling in Lung Cancer

Scientists explored the underlying mechanisms linking the α5-nAChR-Jab1/Csn5 axis with lung cancer epithelial-mesenchymal transition and metastasis, which may provide potential therapeutic targets for future lung cancer treatments. [J Cell Mol Med] Full Article

LncRNA SBF2-AS1 Affects the Radiosensitivity of Non-Small Cell Lung Cancer via Modulating microRNA-302a/MBNL3 Axis

Cells were treated with si-SBF2-AS1 and miR-302a mimics to determine their roles in proliferation and apoptosis of parent strain and resistant strain cells as well as transfected cells. [Cell Cycle] Abstract

miR-125a Regulates HAS1 and Inhibits the Proliferation, Invasion and Metastasis by Targeting STAT3 in Non-Small Cell Lung Cancer Cells

miR-125a was expressed at highest level in A549 among four human non-small cell lung cancer cell lines. Functional studies indicated miR-125a restrained proliferation, invasion, migration, metastasis, and advocated apoptosis of non-small cell lung cancer cells, but had no obvious effect on cell cycle. [J Cell Biochem] Abstract

Involvement of Collagen XVII in Pluripotency Gene Expression and Metabolic Reprogramming of Lung Cancer Stem Cells

Through screening the genes involved in glycolysis, scientists identified the downstream targets of collagen XVII that were involved in metabolic reprogramming of lung cancer stem cells. [J Biomed Sci] Full Article

Long Non-Coding RNA PRNCR1 Modulates Non-Small Cell Lung Cancer Cells Proliferation, Apoptosis, Migration, Invasion and EMT through PRNCR1/miR-126-5p/MTDH Axis

Cell proliferation was measured using Cell Counting Kit-8. Flow cytometry was conducted to determine cell apoptosis. Transwell assay was performed to detect cell migration and invasion in non-small cell lung cancer cells. [Biosci Rep] Abstract

Combination of AAV-Mediated NUPR1 Knockdown and Trifluoperazine Induces Premature Senescence in Human Lung Adenocarcinoma A549 Cells in Nude Mice

An adeno-associated virus (AAV)-mediated nuclear protein 1 (NUPR1) shRNA vector was constructed that effectively inhibited the expression of NUPR1 in a tumor xenograft model derived from lung adenocarcinoma A549 cells. [Oncol Rep] Abstract

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In Search of the Long-Desired ‘Copernican Therapeutic Revolution’ in Small-Cell Lung Cancer

The authors uncover critical aspects of the immune microenvironment and biology of small-cell lung cancer and provide an overview of the current and future landscape of promising therapeutic opportunities. [Drugs] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

US FDA Accepts for Priority Review Bristol-Myers Squibb’s Application for Opdivo (Nivolumab) Plus Yervoy (Ipilimumab) in First-Line Non-Small Cell Lung Cancer

Bristol-Myers Squibb Company announced the FDA has accepted its supplemental Biologics License Application for Opdivo in combination with Yervoy for the first-line treatment of patients with metastatic or recurrent non-small cell lung cancer with no EGFR or ALK genomic tumor aberrations. [Bristol-Myers Squibb Company] Press Release

Oncocyte Announces the Commercial Availability of DetermaRx^™, the First Test for Chemotherapy Benefit Prediction in Patients with Early Stage Non-Small Cell Lung Cancer

Oncocyte Corporation announced that DetermaRx is now commercially available in the United States. DetermaRx enables the identification of early-stage lung cancer patients who may benefit from adjuvant chemotherapy post surgical resection. [Oncocyte Corporation] Press Release

Florida Cracks Down on Foreign Government Involvement in Research

Florida is launching a statewide investigation into US research exploitation after four University of Florida faculty members and six employees of Moffitt Cancer Center in Tampa failed to disclose ties to foreign programs, reports the Tampa Bay Times. [The Scientist] Editorial

FDA and NIH Let Clinical Trial Sponsors Keep Results Secret, Investigation Shows

For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. [STAT News] Editorial

NEW 4^th DNA Repair/Replication Structures and Cancer Conference
February 16-20, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Bronchial Epithelial Cell Analysis (University Medical Center Groningen)

NEW Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology)

Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital)

Postdoctoral Research Scientist – Cancer Research (The Beatson Institute for Cancer Research)

Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

Postdoctoral Fellow – Lung Cancer (Weill Cornell Medicine)

PhD Positions – Heart and Lung Research (International Max Planck Research School for Heart and Lung Research)

Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen)

Postdoctoral Associate – Inflammation (University of Pittsburgh)

PhD Student – Organ-on-Chip (Helmholtz Zentrum München)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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