Pulmonary Cell News Volume 9.02 | Jan 23 2020

TOP STORY

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Investigators showed in primary mouse lung cancer that normalization of tumor vasculature by LIGHT-vascular targeting peptide prevented cancer cell intravasation. [Cell Rep] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

TGF-β1/IL-11/MEK/ERK Signaling Mediates Senescence-Associated Pulmonary Fibrosis in a Stress-Induced Premature Senescence Model of BMI-1 Deficiency

The signaling stimulated cell senescence, senescence-related secretion of TGF-β1 and IL-11 and production of collagen 1 by pulmonary fibroblasts and the epithelial-to-mesenchymal transition of AT2 cells. [Exp Mol Med] Full Article

Gestation and Lactation Exposure to Nicotine Induces Transient Postnatal Changes in Lung Alveolar Development

FACS analysis of individual epithelial alveolar cells revealed nicotine-induced transient increase of alveolar epithelial cells type I proliferation and decrease of vascular endothelial cell proliferation at pnd8. [Am J Physiol Lung Cell Mol Physiol] Abstract

Transcriptional Regulation of the IL-13Rα2 Gene in Human Lung Fibroblasts

Scientists sought to expand the understanding of transcriptional control of receptor α2 in lung fibroblasts. They confirmed previous reports that interleukin-13 elicited modest induction of receptor α2 in normal adult human lung fibroblasts. [Sci Rep] Full Article

Mechanical Forces Induce an Asthma Gene Signature in Healthy Airway Epithelial Cells

Using air-liquid interface cultures of primary human bronchial epithelial cells derived from non-sthmatic donors and asthmatic donors, researchers applied a compressive stress and then used a network approach to map resulting changes in the molecular interactome. [Sci Rep] Full Article

LUNG CANCER

Silencing of LINC00461 Enhances Radiosensitivity of Lung Adenocarcinoma Cells by Down-Regulating HOXA10 via microRNA-195

Scientists investigated the underlying molecular mechanisms of LINC00461/microRNA-195 responsible for its involvement in lung adenocarcinoma. Cell proliferation, migration and invasion were evaluated. [J Cell Mol Med] Abstract

Circular RNA circABCC4 Regulates Lung Adenocarcinoma Progression via miR-3186-3p/TNRC6B Axis

Functional assays elucidated that knockdown of circABCC4 significantly impaired lung adenocarcinoma cell proliferation, migration as well as accelerated cell apoptosis. [J Cell Biochem] Abstract

microRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, While Retaining Oncolytic Potency against Lung Cancer

In vitro experiments revealed that miR-coxsackievirus B3 retained the ability to infect and lyse KRAS-mutant lung adenocarcinoma and TP53/RB1-mutant small cell lung cancer cells, but with a markedly reduced cytotoxicity towards cardiomyocytes. [Mol Ther Oncolytics] Abstract

Long Non-Coding RNA XIST Expedites Lung Adenocarcinoma Progression through Upregulating MDM2 Expression via Binding to miR-363-3p

Researchers found that X-inactive specific transcript (XIST) and mouse double minute clone 2 (MDM2) were remarkably elevated while miR-363-3p was reduced in lung adenocarcinoma tissues and cells. [Thorac Cancer] Abstract

Targeting Folate Receptor β Positive Tumor-Associated Macrophages in Lung Cancer with a Folate-Modified Liposomal Complex

The authors utilized a folate-modified lipoplex comprising a folate-modified liposome delivering a BIM-S plasmid to target both lung cancer cells and folate receptor β-positive macrophages in the tumor microenvironment. [Signal Transduct Target Ther] Full Article

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A Summary of In Vitro and In Vivo Studies Evaluating the Impact of E-Cigarette Exposure on Living Organisms and the Environment

The authors examine the effects of selected liquid chemicals used in e-cigarettes, such as propylene glycol/vegetable glycerin, nicotine and flavorings, on living organisms. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

LUNGevity and the ALK Positive Group Partner to Fund $1 Million in Lung Cancer Research Awards

LUNGevity Foundation is partnering for the second time with patient-led group ALK Positive to support the ALK-positive Lung Cancer Research Award Program. The group will fund at least two research awards up to a total of $1 million over two years-their largest funding to date. [LUNGevity Foundation] Press Release

AXIM^® Biotechnologies Acquiree Sapphire Biotech, Inc. Signs License Agreement to Exclusively License Patent Rights in Cancer Technology

AXIM^® Biotechnologies, Inc. an international healthcare solutions company targeting oncological research, announced that its acquiree Sapphire Biotech, Inc. has signed an agreement with Skysong Innovations, LLC to exclusively license rights to pharmaceutical compositions and methods for the treatment of cancer. [AXIM^® Biotechnologies, Inc.] Press Release

‘We Need a People’s Cryo-EM’ Scientists Hope to Bring Revolutionary Microscope to the Masses

The Laboratory for Molecular Biology, clad in glass the color of sea ice, rises like a futuristic factory above the rapeseed fields of Cambridge, UK. It is the crown jewel of the UK Medical Research Council, a storied government lab that has garnered more than a dozen Nobel Prizes. [ScienceInsider] Editorial

Campus Attacks by Nationalists and Police Alarm India’s Scientific Community

The attack on one of India’s most prestigious universities sent shock waves around the country and is the latest sign that the political forces tearing apart Indian society are also affecting the country’s academic community. Students at JNU, a liberal bastion, had been on strike for months against both a major hike in student fees and the government’s controversial Citizenship Amendment Act, widely decried as discriminatory against Muslims. [ScienceInsider] Editorial

NEW 2^nd Epigenetics Conference
February 28-March 2, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholarship – Cancer Drug Discovery (Karolinska Institutet)

Postdoctoral Position – Bronchial Epithelial Cell Analysis (University Medical Center Groningen)

Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology)

Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital)

Postdoctoral Research Scientist – Cancer Research (The Beatson Institute for Cancer Research)

Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

Postdoctoral Fellow – Lung Cancer (Weill Cornell Medicine)

PhD Positions – Heart and Lung Research (International Max Planck Research School for Heart and Lung Research)

Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen)

PhD Student – Organ-on-Chip (Helmholtz Zentrum München)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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