Pulmonary Cell News Volume 9.03 | Jan 30 2020

TOP STORY

Tobacco Smoking and Somatic Mutations in Human Bronchial Epithelium

Scientists sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects. Tobacco smoking was the major influence on mutational burden, typically adding from 1,000 to 10,000 mutations per cell. [Nature] Abstract

(Ranked by impact factor of the journal)

TLR5 Participates in the TLR4 Receptor Complex and Promotes MyD88-Dependent Signaling in Environmental Lung Injury

Investigators demonstrated that immune cells of human carriers of a dominant negative toll-like receptor (TLR)5 allele haved decreased inflammatory response to O₃ exposure ex vivo and lipopolysaccharide exposure in vitro. [eLife] Abstract

Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma

Researchers addressed the role of endogenous IL-33 and its autoamplification of the IL-33/ST2 pathway in Ag-dependent and Ag-independent asthma-like models. IL-33 induced its own mRNA and ST2L mRNA expression in the lung. [J Immunol] Abstract

MicroRNA-30a Attenuates TGF-β1-Induced Activation of Pulmonary Fibroblast Cell by Targeting FAP-α

In MRC5 cells, miR-30a was not only involved in regulating the expression of FAP-α, col1a and α-SMA induced by TGF-β1, but also had a role in cell proliferation with or without TGF-β1 treatment via regulating FAP-α expression. [J Cell Mol Med] Full Article

Comparative Therapeutic Potential of ALX-0171 and Palivizumab against Respiratory Syncytial Virus Clinical Isolate Infection of Well-Differentiated Primary Pediatric Bronchial Epithelial Cell Cultures

Investigators exploited their well-differentiated primary pediatric bronchial epithelial cell/respiratory syncytial virus infection model, which replicated several hallmarks of respiratory syncytial virus disease in vivo. [Antimicrob Agents Chemother] Abstract

LUNG CANCER

Biodegradable Polymeric Multilayer Capsules for Therapy of Lung Cancer

The authors demonstrated the delivery of low-molecular-weight drug molecules to lung cancer cells and macrophages and provided details on in vivo distribution, cellular uptake, and disintegration of the developed polymeric multilayer capsules. [ACS Appl Mater Interfaces] Abstract

PIM Kinases Alter Mitochondrial Dynamics and Chemosensitivity in Lung Cancer

Scientists determined how PIM kinases impacted mitochondrial dynamics, ROS production, and response to chemotherapy in lung cancer. Inhibition of PIM sensitized non-small-cell lung cancer cells to chemotherapy and produced a synergistic antitumor response in vitro and in vivo. [Oncogene] Abstract

Overexpression of PSAT1 Promotes Metastasis of Lung Adenocarcinoma by Suppressing the IRF1-IFNγ Axis

Researchers showed that the knockdown of phosphoserine aminotransferase 1 (PSAT1) dramatically inhibited the in vitro and in vivo metastatic potential of highly metastatic lung cancer cells. [Oncogene] Abstract

Gold Nanoparticle Based Double-Labeling of Melanoma Extracellular Vesicles to Determine the Specificity of Uptake by Cells and Preferential Accumulation in Small Metastatic Lung Tumors

Investigators determined the cell-type specific tropism of B16F10-extracellular vesicles towards cancer cell and metastatic tumors by using fluorescence analysis and quantitative gold labeling measurements. [J Nanobiotechnology] Full Article

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Multifaceted Roles of Caveolin-1 in Lung Cancer: A New Investigation Focused on Tumor Occurrence, Development and Therapy

The authors summarize the valuable research on caveolin-1 (Cav-1) and lung cancer in recent years and discuss the multifaceted roles of Cav-1 on lung cancer occurrence, development and therapy, hoping to provide new insights into lung cancer treatment. [Cancers] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

PharmaMar and Bionical Emas Launch Expanded Access Program for Lurbinectedin in Relapsed Small Cell Lung Cancer in the US

PharmaMar and Bionical Emas announced the launch of an Expanded Access Program for lurbinectedin to treat patients in the US with relapsed small cell lung cancer, who are unable to enter clinical trials and there are no appropriate alternative treatments. [PharmaMar, Inc.] Press Release

MediciNova Receives Notice of Intention to Grant for New Patent Covering MN-001 for the Treatment of Idiopathic Pulmonary Fibrosis in Europe

MediciNova, Inc. announced that it has received a Notice of Intention to Grant from the European Patent Office for a pending patent application which covers MN-001 for the treatment of idiopathic pulmonary fibrosis. [MediciNova, Inc.] Press Release

UK and EU: Cherish What You Have Achieved and Stay Close

Most scientists didn’t want Brexit. UK researchers do not yet know if they will be part of joint EU research programmes. However, in one piece of welcome news, the futures of the many EU researchers who want to make their lives in Britain now lie in the hands of the UK Research and Innovation agency, and not the UK Home Office – an institution that, for much of the past decade, enacted and implemented policies to reduce immigration to the United Kingdom. [Nature News] Editorial

Top Harvard Chemist Charged with Lying about Ties to Chinese Government Program

The head of Harvard University’s chemistry department was charged with attempting to conceal his involvement in a Chinese government program to bring scientists to China, an escalation of a crackdown by US authorities on what they perceive as a campaign to steal ideas born in American universities and medical centers. [STAT News] Editorial

NEW American Association for Cancer Research (AACR) Meeting: The Evolving Landscape of Cancer Modeling
March 2-5, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center)

NEW Postdoctoral Fellowship – Stem Cell Niche in Lung Fibrosis (University of California)

Postdoctoral Scholarship – Cancer Drug Discovery (Karolinska Institutet)

Postdoctoral Position – Bronchial Epithelial Cell Analysis (University Medical Center Groningen)

Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology)

Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital)

Postdoctoral Research Scientist – Cancer Research (The Beatson Institute for Cancer Research)

Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

Postdoctoral Fellow – Lung Cancer (Weill Cornell Medicine)

PhD Positions – Heart and Lung Research (International Max Planck Research School for Heart and Lung Research)

Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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