Pulmonary Cell News 9.06 February 20, 2020 | |
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TOP STORYResearchers demonstrated that Bruceine D (BD) inhibited lung cancer cell proliferation. Apoptosis and autophagy were the most important mechanisms involved in BD-induced lung cancer cell death, and complete autophagic flux was observed in A549 and NCI-H292 cells. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Microcystin-LR Ameliorates Pulmonary Fibrosis via Modulating CD206+ M2-Like Macrophage Polarization Data indicated that treatment with microcystin-leucine arginine (LR) substantially reduced TGF-β1/Smad signaling in rat pulmonary tissues. [Cell Death Dis] Full Article Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury Scientists report that the loss of autophagy-related 5 in AT2 cells worsened bleomycin-induced lung injury. Mechanistically, during bleomycin injury, autophagy downregulated lipid metabolism but upregulated glucose metabolism in AT2 cells for alveolar repair. [Stem Cell Reports] Full Article In the intermittent hypoxia -treated RAW264.7 cells, SOD2 knockdown increased the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation accompanied with the IL-1β elevation and caspase-1 activity. [Acta Pharmacol Sin] Abstract BEAS-2B cells treated with astragaloside IV, and then stimulated with TNF-α or TNF-α/IL-4. The levels of cytokine and chemokine were analysed with ELISA and real-time PCR. [Arch Physiol Biochem] Abstract LUNG CANCERIntracellular localization and strong recovered fluorescence signals of HSA-CAPN2 were observed in vitro experiments using A549-Luc cells, and signal recovery was inhibited by ALLN. [Bioconjug Chem] Abstract Time-resolved spectral profiles and fluorescence lifetime images of nicotinamide adenine dinucleotide and flavin adenine dinucleotide were obtained in human lung non-small carcinomas and normal lung cells. [J Biophotonics] Abstract The authors investigated the effects of chalcomoracin (CMR) against human non-small cell lung cancer cells and the underlying mechanisms. They found that CMR dose-dependently inhibited the proliferation of human lung cancer H460, A549 and PC-9 cells. [Acta Pharmacol Sin] Abstract SKA3 Promotes Lung Adenocarcinoma Metastasis through the EGFR-PI3K-Akt Axis Spindle and kinetochore associated complex subunit 3 (SKA3) silencing experiments identified SKA3 as an oncogene that promoted the metastasis of lung adenocarcinoma cell lines and tissues. [Biosci Rep] Abstract Class A CpG Oligodeoxynucleotide Inhibits IFN-γ-Induced Signaling and Apoptosis in Lung Cancer Western blots were used to measure the molecules which regulate the expression of PD-L1 in human lung cancer cell lines after incubation with several cytokines and oligodeoxynucleotides. [Thorac Cancer] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSPre-Clinical Models of Small Cell Lung Cancer and the Validation of Therapeutic Targets The authors describe the current pre-clinical models that have been developed to interrogate small cell lung cancer, and outline the benefits and limitations associated with each. [Expert Opin Ther Targets] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSRoche, Inc. announced that the FDA has accepted the company’s supplemental Biologics License Application and granted Priority Review for Tecentriq® as a first-line monotherapy for people with advanced non-squamous and squamous non-small cell lung cancer without EGFR or ALK mutations with high PD-L1 expression. [Roche, Inc.] Press Release PharmaMar and Jazz Pharmaceuticals plc announce that the FDA accepted for filing with Priority Review the New Drug Application seeking accelerated approval for lurbinectedin for the treatment of patients with small cell lung cancer who have progressed after prior platinum-containing therapy. [Jazz Pharmaceuticals plc] Press Release | |
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POLICY NEWSThe Next Chapter for African Genomics Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way. [Nature News] Editorial ‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial
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EVENTSNEW European Lung Cancer Congress 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Scholar – Cancer Metabolism (The Ohio State University) Postdoctoral Training Fellow – Stem Cells in Tuberculosis (The Francis Crick Institute) Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center) Postdoctoral Fellowship – Stem Cell Niche in Lung Fibrosis (University of California) Postdoctoral Position – Bronchial Epithelial Cell Analysis (University Medical Center Groningen) Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology) Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute) Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital) Postdoctoral Research Scientist – Cancer Research (The Beatson Institute for Cancer Research) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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