Pulmonary Cell News 9.08 March 5, 2020 | |
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TOP STORYClub Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation Scientists report how epithelial cells recognize and respond to aeroallergen alkaline protease 1 of Aspergillus sp., and they linked fungal sensitization and/or asthma with SNP/protein expression of the mechanosensitive calcium channel, TRPV4. [Cell Host Microbe] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Inhalation of Lung Spheroid Cell Secretome and Exosomes Promotes Lung Repair in Pulmonary Fibrosis Researchers present a series of studies utilizing lung spheroid cell-secretome and exosomes by inhalation to treat different models of lung injury and fibrosis. [Nat Commun] Full Article In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution Investigators used homogeneous human bud tip organoid cultures and identified SMAD signaling as a key regulator of the bud tip-to-airway transition. [Dev Cell] Full Article Researchers found that fibroblast growth factors (FGF)9 signaled through epithelial FGF receptor 3 to directly promote distal epithelial fate specification and inhibit epithelial differentiation. [Sci Signal] Abstract BEAS-2B cells were transfected with silencing RNA specific to Nrf2 and exposed to diesel exhaust particles. The relative levels of mRNA for Nrf2, NQO1, HO-1, LC3B, p62 and Atg5 were determined using RT-PCR, while the levels of LCB3, Nrf2, and p62 protein were determined using Western blotting. [Sci Rep] Full Article Adjuvant Contributes Roundup’s Unexpected Effects on A549 Cells The authors demonstrated that Roundup® and polyethoxylated tallow amine could inhibit the proliferation of human lung A549 cells. [Environ Res] Abstract MeCP2 Epigenetically Regulates Alpha-Smooth Muscle Actin in Human Lung Fibroblasts Scientists used chromatin immunoprecipitation assays in primary fibroblasts from idiopathic pulmonary fibrosis (IPF) and non-IPF control individuals, and in lung fibroblasts treated with profibrotic cytokine transforming growth factor β. [J Cell Biochem] Abstract Investigators showed that an isolate of H. capsulatum chemotype I induced lower levels of interleukin (IL)-8 secretion by the lung epithelial cell line A549, when compared to chemotype II yeasts. [Med Mycol] Abstract LUNG CANCEROverproduction of FGF19 in lung squamous cell carcinoma (LSQ) cells markedly promoted cell growth, progression and metastasis, while downregulating FGF19 effectively inhibited LSQ progression in vitro and in vivo. [Oncogene] Full Article Blocking EGFR Palmitoylation Suppresses PI3K Signaling and Mutant KRAS Lung Tumorigenesis Knocking down DHHC20 reduced the growth of existing tumors derived from human KRAS-mutant lung cancer cells and increased the sensitivity of these cells to a PI3K inhibitor. [Sci Signal] Abstract Three NSCLC cell lines were transfected to observe behavior changes BCAP31 caused. Scientists found the fluctuation of BCAP31 significantly influenced the migration, and invasion of NSCLC cells. [Sci Rep] Full Article Researchers evaluated the effect of geraniol on some oxidative parameters in human tumor cell lines. Cytotoxicity was evaluated in cell lines by the MTT assay, genotoxicity by the comet assay, and lipid peroxidation by the TBARS. [Chem Biol Interact] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSScientists review the latest studies describing the features and types of epidermal growth factor receptor (EGFR) pathogenic mutations, currently established EGFR-tyrosine kinase inhibitors from the first to fourth generation. [J Drug Target] Abstract Non-Coding RNA Profile in Lung Cancer Integrative assessment of expression of lncRNAs, miRNAs and mRNAs has led to construction of competing endogenous RNA networks. The authors summarize recent findings about the importance of these networks in the pathogenesis of lung cancer and provide a list of onco-miRNAs, tumor suppressor miRNAs, oncogenic lncRNAs and tumor suppressor lncRNAs based on their roles in the carcinogenic process in lung cancer. [Exp Mol Pathol] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSVerastem Oncology Announces New Strategic Direction to Advance Its Clinical Development Programs Verastem, Inc. announced a new strategic direction to accelerate the advancement of certain of its clinical development programs. The company’s primary focus will be on the development of CH5126766, its RAF/MEK inhibitor, in combination with defactinib, its focal adhesion kinase inhibitor, for the treatment of KRAS mutant solid tumors. [Verastem, Inc.] Press Release Takeda Pharmaceutical Company Limited announced that the European Medicines Agency’s Committee for Medicinal Products (CHMP) for Human Use adopted a positive opinion recommending the approval of ALUNBRIG as a monotherapy for the treatment of adult patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer previously not treated with an ALK inhibitor. [Takeda Pharmaceutical Company Limited] Press Release | |
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POLICY NEWSChina Bans Cash Rewards for Publishing Papers Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial UC Santa Cruz Fires Graduate Students Taking Part in Strike The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Cystic Fibrosis (Michigan State University) Research Associate – Lung Tumors (University of Cambridge) Research Associate and Lab Manager – In Vitro Cancer Models (Flanders Institute for Biotechnology) Postdoctoral Scholar – Cancer Metabolism (The Ohio State University) Postdoctoral Training Fellow – Stem Cells in Tuberculosis (The Francis Crick Institute) Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center) Postdoctoral Fellowship – Stem Cell Niche in Lung Fibrosis (University of California, San Francisco) Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology) Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute) Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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