 | | Vol. 5.26 – 09 July, 2020 |
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| Scientists demonstrated that aveolar macrophages, but not epithelial cells (ECs), constitutively secreted paracrine activity localized to extracellular vesicles which inhibited influenza infection of ECs in vitro and in vivo.
[EMBO Journal] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Primary bronchial epithelial cells (mBECs) were extracted, and the expression of TGF signaling pathway‐, autophagy‐ and PI3K/Akt/mTOR signaling pathway‐related proteins in mBECs was detected by immunofluorescence assay and Western blot analysis.
[Journal of Cellular and Molecular Medicine] |
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| Scientists examined 8-nitroG formation in A549 cultured human lung epithelial cells treated with indium compounds, including nanoparticles of indium oxide and indium-tin oxide, and indium chloride
[Scientific Reports] |
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| Investigators aimed to explore the roles and the underlying mechanisms of Isoliquiritigenin in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.
[Acta Biochimica et Biophysica Sinica] |
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| Researchers identified a group of Y chromosome-expressed long non-coding RNA that were involved in male NSCLC radiation sensitivity.
[Cancer Research] |
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| Scientists showed that PD-L1 regulated lung cancer growth and progression by targeting the WIP and β-catenin signaling. Overexpression of PD-L1 promoted tumor cell growth, migration and invasion in lung cancer cells, whereas PD-L1 knockdown had the opposite effects.
[Cell Death & Disease] |
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| To test the possible role Fibulin-1 isoforms could have in regulating Epidermal Growth Factor Receptor signaling and function in lung cancer, scientists performed siRNA mediated knockdown of FBLN1C and FBLN1D in non-small cell lung cancer Calu-1 cells.
[Frontiers in Cell and Developmental Biology] |
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| The authors investigated the possibility that pirfenidone might exert an anti-tumor effect through inhibition of fibroblast activation and the tumor-stroma interaction in NSCLC cell lines in vitro and in vivo.
[Scientific Reports] |
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| Distribution of LINC02323 was detected by the nuclear‐plasma separation experiment. Cell proliferation was assessd by MTT assay, and cell migration and invation were detected by transwell assays.
[Thoracic Cancer] |
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| The authors focus exclusively on the role of NF-κB in NSCLC and discuss its contributing effect on cancer hallmarks such as inflammation, proliferation, survival, apoptosis, angiogenesis, epithelial-mesenchymal transition, metastasis, stemness, metabolism, and therapy resistance.
[Cancer Research] |
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| A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science] |
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| Angion Biomedica Corp. announced it has initiated in Brazil a randomized, placebo-controlled Phase II proof-of-concept trial of ANG-3777 plus standard of care in patients with acute lung injury associated with COVID-19 pneumonia.
[Angion Biomedica Corp.] |
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| Kitov Pharma Ltd. announced the initiation of the first study site in a Phase I/II clinical trial of NT219, a dual inhibitor, novel small molecule targeting IRS1/2 and STAT3, important oncogenic drivers and major drug resistance pathways in many hard-to-treat cancers.
[Kitov Pharma Ltd (GlobeNewswire, Inc.)] |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | NYU School of Medicine – New York, New York, United States |
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