Pulmonary Cell News Volume 9.27 | Jul 16 2020

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    PULCN 5.27 | Jul 16


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 5.27 – 16 July, 2020
    TOP STORY

    Persistence of a Regeneration-Associated, Transitional Alveolar Epithelial Cell State in Pulmonary Fibrosis

    Using lung organoids, multiple in vivo repair models, single-cell transcriptomics and lineage tracing, researchers found that alveolar type-2 epithelial cells undergoing differentiation into type-1 cells acquired pre-alveolar type-1 transitional cell state en route to terminal maturation.
    [Nature Cell Biology]

    Abstract
    Optimizing in vitro lung models with Dr. Rachael Rayner.
    PUBLICATIONSRanked by the impact factor of the journal

    Alveolar Regeneration through a Krt8+ Transitional Stem Cell State That Persists in Human Lung Fibrosis

    Trajectory modeling together with lineage tracing revealed that airway and alveolar stem cells converged on a unique Krt8+ transitional stem cell state during alveolar regeneration.
    [Nature Communications]

    Full Article

    Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

    Scientists report that remdesivir potently inhibited SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    LncRNA RP11-86H7.1 Promotes Airway Inflammation Induced by TRAPM 2.5 by Acting as a ceRNA of miRNA-9-5p to Regulate NFKB1 in HBECS

    Researchers investigated the effect of TRAPM2.5 on airway inflammation in human bronchial epithelial cells and the underlying mechanisms mediated by a lncRNA.
    [Scientific Reports]

    Full Article

    Therapeutic Targeting of 15-PGDH in Murine Pulmonary Fibrosis

    Long-term pharmacologic 15-PGDH inhibition (PGDHi) was well-tolerated, reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling, and improved pulmonary function in bleomycin-treated mice.
    [Scientific Reports]

    Full Article

    Ubiquitin Ligase SMURF2 Enhances Epidermal Growth Factor Receptor Stability and Tyrosine-Kinase Inhibitor Resistance

    Scientists identified four lysine residues as the sites of ubiquitination, and showed that replacement of one of them with acetylation-mimicking glutamine increased the sensitivity of mutant EGFR to erlotinib-induced degradation.
    [Journal of Biological Chemistry]

    Abstract

    ASXL3 Bridges BRD4 to BAP1 Complex and Governs Enhancer Activity in Small Cell Lung Cancer

    Biochemistry studies, including size exclusion chromatography, mass spectrometry, and western blot analysis, were conducted to determine the protein-protein interaction between additional sex combs-like protein 3 (ASXL3) and bromodomain-containing protein 4.
    [Genome Medicine]

    Full Article

    DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies Crebbp as a Predictive Biomarker of Volasertib in Small Cell Lung Carcinoma (SCLC)

    Applying DrugSniper to SCLC, scientists identified genes extensively explored in SCLC. The analysis suggested a remarkable vulnerability to polo-like kinase 1 inhibition in CREBBP-mutant SCLC cells.
    [Cancers]

    Full Article

    Circular RNAa Circ-LDLRAD3 Serves as an Oncogene to Promote Non-Small Cell Lung Cancer Progression by Upregulating SLC1A5 through Sponging MiR-137

    Investigators conducted an in vitro study and found that knock-down of circ-LDLRAD3 inhibited the development of NSCLC by regulating miR-137/SLC1A5 axis.
    [RNA Biology]

    Abstract

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    REVIEWS

    Resistance to Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Biomarkers and Therapeutic Strategies

    The authors highlight the absence of a common definition of primary and secondary resistance and summarize their frequency and clinical characteristics.
    [Therapeutic Advances in Medical Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Calithera Biosciences Initiates Phase Ib Trial of Arginase Inhibitor CB-280 for the Treatment of Cystic Fibrosis

    Calithera Biosciences, Inc. announced that it has dosed the first patients in its Phase Ib clinical trial of the arginase inhibitor CB-280 in adult patients with cystic fibrosis and chronic airway infection. The study will evaluate the safety and optimal dose range of CB-280 when added onto existing therapies for cystic fibrosis patients, including CFTR modulators.
    [Calithera Biosciences, Inc. ]

    Press Release

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    FEATURED EVENT

    The New York Stem Cell Foundation (NYSCF) Conference

    October 20 – October 21
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Computational Medicine of the Lungs

    Institute for Computational Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Researcher – Inhalation and Developmental Toxicology

    Louisiana State University – Baton Rouge, Louisiana, United States

    Postdoctoral Research Fellow – Biology of Small Cell Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Fellow – Lung Cancer Biology

    Virginia Commonwealth University – Richmond, Virginia, United States

    > See All Jobs

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