| Vol. 5.27 – 16 July, 2020 |
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| Using lung organoids, multiple in vivo repair models, single-cell transcriptomics and lineage tracing, researchers found that alveolar type-2 epithelial cells undergoing differentiation into type-1 cells acquired pre-alveolar type-1 transitional cell state en route to terminal maturation. [Nature Cell Biology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Trajectory modeling together with lineage tracing revealed that airway and alveolar stem cells converged on a unique Krt8+ transitional stem cell state during alveolar regeneration. [Nature Communications] |
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| Scientists report that remdesivir potently inhibited SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures. [Cell Reports] |
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| Researchers investigated the effect of TRAPM2.5 on airway inflammation in human bronchial epithelial cells and the underlying mechanisms mediated by a lncRNA. [Scientific Reports] |
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| Long-term pharmacologic 15-PGDH inhibition (PGDHi) was well-tolerated, reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling, and improved pulmonary function in bleomycin-treated mice. [Scientific Reports] |
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| Scientists identified four lysine residues as the sites of ubiquitination, and showed that replacement of one of them with acetylation-mimicking glutamine increased the sensitivity of mutant EGFR to erlotinib-induced degradation. [Journal of Biological Chemistry] |
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| Biochemistry studies, including size exclusion chromatography, mass spectrometry, and western blot analysis, were conducted to determine the protein-protein interaction between additional sex combs-like protein 3 (ASXL3) and bromodomain-containing protein 4. [Genome Medicine] |
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| Applying DrugSniper to SCLC, scientists identified genes extensively explored in SCLC. The analysis suggested a remarkable vulnerability to polo-like kinase 1 inhibition in CREBBP-mutant SCLC cells. [Cancers] |
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| Investigators conducted an in vitro study and found that knock-down of circ-LDLRAD3 inhibited the development of NSCLC by regulating miR-137/SLC1A5 axis. [RNA Biology] |
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| The authors highlight the absence of a common definition of primary and secondary resistance and summarize their frequency and clinical characteristics. [Therapeutic Advances in Medical Oncology] |
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| Calithera Biosciences, Inc. announced that it has dosed the first patients in its Phase Ib clinical trial of the arginase inhibitor CB-280 in adult patients with cystic fibrosis and chronic airway infection. The study will evaluate the safety and optimal dose range of CB-280 when added onto existing therapies for cystic fibrosis patients, including CFTR modulators. [Calithera Biosciences, Inc. ] |
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| Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing. [Nature News] |
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| Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences. [Science Insider] |
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| October 20 – October 21 Virtual |
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| Institute for Computational Medicine – Baltimore, Maryland, United States |
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| Columbia University Medical Center – New York, New York, United States |
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| Louisiana State University – Baton Rouge, Louisiana, United States |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| Virginia Commonwealth University – Richmond, Virginia, United States |
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