| Vol. 9.29 – 30 July, 2020 |
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| Investigators evaluated the antiviral activity of hydroxychloroquine (HCQ) both in vitro and in SARS-CoV-2-infected macaques. HCQ showed antiviral activity in African green monkey kidney cells but not in a model of reconstituted human airway epithelium. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells, rendered SARS-CoV-2 infection of Vero cells insensitive to chloroquine. [Nature] |
| | Using transgenic mice and pharmacologic studies, the authors found that Wnt/β-catenin within airway basal stem cells was essential for proliferation post-injury in vivo. [Cell Stem Cell] |
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| Scientists explored the cellular heterogeneity of the human airway epithelium in 10 healthy living volunteers by single-cell RNA profiling. 77,969 cells were collected at 35 distinct locations, from the nose to the 12th division of the airway tree. [American Journal of Respiratory and Critical Care Medicine] |
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| Investigators explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation. [FASEB Journal] |
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| Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema. [COPD-Journal of Chronic Obstructive Pulmonary Disease] |
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| Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers. [Oncogene] |
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| The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients. [Molecular Therapy-Nucleic Acids] |
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| Researchers identified a circular form of ASPH RNA, expression of which was upregulated in lung adenocarcinoma and the human lung adenocarcinoma cell lines. [Cell Death & Disease] |
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| The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells. [Journal of Cellular Biochemistry] |
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| Researchers established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma. Extensive gene and histopathology profiling showed that the tumor organoids retained the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors. [iScience] |
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| Pulmonary toxicity from taxanes presents as an ILD‐type reaction characterized by increasing dyspnoea, dry cough, fever and bilateral pulmonary interstitial infiltrates. [Respirology] |
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| AstraZeneca’s Breztri Aerosphere has been approved in the US for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). [AstraZeneca] |
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| The French government unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years. [ScienceInsider] |
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| Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China. [The Scientist] |
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| October 21 – October 25 Virtual |
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| University of British Columbia – Vancouver, British Columbia, Canada |
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| Institute for Computational Medicine – Baltimore, Maryland, United States |
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| Columbia University Medical Center – New York, New York, United States |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| Virginia Commonwealth University – Richmond, Virginia, United States |
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