Pulmonary Cell News Volume 9.29 | Jul 30 2020

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    PULCN 9.29 | July 30


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.29 – 30 July, 2020
    TOP STORY

    Hydroxychloroquine Use against SARS-CoV-2 Infection in Non-Human Primates

    Investigators evaluated the antiviral activity of hydroxychloroquine (HCQ) both in vitro and in SARS-CoV-2-infected macaques. HCQ showed antiviral activity in African green monkey kidney cells but not in a model of reconstituted human airway epithelium.
    [Nature]

    AbstractFull Article

    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    Chloroquine Does Not Inhibit Infection of Human Lung Cells with SARS-CoV-2

    Researchers showed that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells, rendered SARS-CoV-2 infection of Vero cells insensitive to chloroquine.
    [Nature]

    AbstractFull Article

    Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

    Using transgenic mice and pharmacologic studies, the authors found that Wnt/β-catenin within airway basal stem cells was essential for proliferation post-injury in vivo.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    A Single-Cell Atlas of the Human Healthy Airways

    Scientists explored the cellular heterogeneity of the human airway epithelium in 10 healthy living volunteers by single-cell RNA profiling. 77,969 cells were collected at 35 distinct locations, from the nose to the 12th division of the airway tree.
    [American Journal of Respiratory and Critical Care Medicine]

    Abstract

    Glycogen Synthase Kinase‐3β Promotes Radiation‐Induced Lung Fibrosis by Regulating β‐Catenin/lin28 Signaling Network to Determine Type II Alveolar Stem Cell Transdifferentiation State

    Investigators explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation.
    [FASEB Journal]

    Full Article

    Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

    Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
    [COPD-Journal of Chronic Obstructive Pulmonary Disease]

    Abstract

    Impaired AKT Signaling and Lung Tumorigenesis by PIERCE1 Ablation in KRAS-Mutant Non-Small Cell Lung Cancer

    Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
    [Oncogene]

    Full Article

    CircSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer by Targeting miR-520h/ABCG2 Pathway

    The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    HMGA2 Regulates Circular RNA ASPH to Promote Tumor Growth in Lung Adenocarcinoma

    Researchers identified a circular form of ASPH RNA, expression of which was upregulated in lung adenocarcinoma and the human lung adenocarcinoma cell lines.
    [Cell Death & Disease]

    Full Article

    Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells

    The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
    [Journal of Cellular Biochemistry]

    Abstract

    Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

    Researchers established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma. Extensive gene and histopathology profiling showed that the tumor organoids retained the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
    [iScience]

    AbstractGraphical Abstract

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    REVIEWS

    Pulmonary Toxicity of Systemic Lung Cancer Therapy

    Pulmonary toxicity from taxanes presents as an ILD‐type reaction characterized by increasing dyspnoea, dry cough, fever and bilateral pulmonary interstitial infiltrates.
    [Respirology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Breztri Aerosphere Approved in the US for the Maintenance Treatment of COPD

    AstraZeneca’s Breztri Aerosphere has been approved in the US for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).
    [AstraZeneca]

    Press Release

    French Science Bill Promises Boost to Public R&D

    The French government unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Editorial

    Foreign Researchers Accused of Hiding Links to Chinese Military

    Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
    [The Scientist]

    Editorial

    FEATURED EVENT

    ESCMID Conference on Corona Virus Disease (ECCVID)

    October 21 – October 25
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professors – Respiratory Transnational Research

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellowship – Computational Medicine of the Lungs

    Institute for Computational Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Research Fellow – Biology of Small Cell Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Fellow – Lung Cancer Biology

    Virginia Commonwealth University – Richmond, Virginia, United States

    > See All Jobs

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