Pulmonary Cell News Volume 9.30 | Aug 6 2020

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    2020-08-06 | PULCN 9.30


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.30 – 6 August, 2020
    TOP STORY

    Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

    The authors leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories of alveolar-lineage cells during injury repair and lung regeneration.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    A Lung Tropic AAV Vector Improves Survival in a Mouse Model of Surfactant B Deficiency

    Scientists report a rationally designed adeno-associated virus 6 capsid that demonstrated efficiency in lung epithelial cell transduction based on imaging and flow cytometry analysis.
    [Nature Communications]

    Full Article

    Morphogenesis and Cytopathic Effect of SARS-CoV-2 Infection in Human Airway Epithelial Cells

    Investigators characterized the replication dynamics, cell tropism and morphogenesis of SARS-CoV-2 in organotypic human airway epithelial cultures.
    [Nature Communications]

    Full Article

    Development of a Miniaturized 96-Transwell Air-Liquid Interface Human Small Airway Epithelial Model

    A 96-well microplate system was developed where primary human small airway epithelial cells were cultured at an air-liquid interface (ALI). After four weeks of ALI culture, a pseudostratified epithelium containing basal, club, goblet and ciliated cells was produced.
    [Scientific Reports]

    Full Article

    Aesculetin Attenuates Alveolar Injury and Fibrosis Induced by Close Contact of Alveolar Epithelial Cells with Blood-Derived Macrophages via IL-8 Signaling

    Human alveolar epithelial A549 cells were cultured for 24 hours in conditioned media of THP-1 monocyte-derived macrophages with 1–20 μM aesculetin.
    [International Journal of Molecular Sciences]

    Full Article

    LUNG CANCER

    Small Cell Transformation of ROS1 Fusion-Positive Lung Cancer Resistant to ROS1 Inhibition

    Evidence of small cell transformation was observed in all metastatic sites at autopsy, with inactivation of RB1 and TP53, and loss of ROS1 fusion expression.
    [npj Precision Oncology]

    Full Article

    miR-135a Inhibits Non-Small Cell Lung Cancer Progression by Suppressing RAB1B Expression and the RAS Pathway

    Researchers showed that miR-135a was aberrantly downregulated in non-small cell lung cancer (NSCLC) cells in comparison with normal bronchial epithelial cells, and the expression of miR-135a inhibited proliferation, invasion and metastasis of NSCLC cells in vitro.
    [Aging]

    Full Article

    miR-4634 Augments the Anti-Tumor Effects of RAD001 and Associates Well with Clinical Prognosis of Non-Small Cell Lung Cancer

    miRNA microarray analysis showed that miR-4634 levels in A549 cells increased significantly after everolimus treatment. Decreased expression of miR-4634 was also found in non-small-cell lung carcinoma cell lines and patients’ tumors by qPCR.
    [Scientific Reports]

    Full Article

    LINC00324 Affects Non-Small Cell Lung Cancer Cell Proliferation and Invasion through Regulation of the miR-139-5p/IGF1R Axis

    Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanisms.
    [Molecular and Cellular Biochemistry]

    Abstract

    Comprehensive Analysis of Circular RNA Expression Profiles in Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines

    Two cisplatin-resistant non-small cell lung cancer cell lines were established by gradually increasing concentrations of cisplatin in the media. The resulting cell lines possessed high resistance to cisplatin and strong proliferation, migration, and colony formation abilities compared to the parental cells.
    [Acta Biochimica Et Biophysica Sinica]

    Abstract

    Your cultureware impacts your ALI cultures.
    REVIEWS

    Opportunities and Obstacles of Targeted Therapy and Immunotherapy in Small Cell Lung Cancer

    The authors review the molecular biology characteristics of small cell lung cancer (SCLC) and discuss the opportunities and obstacles of the current therapy for SCLC patients.
    [Journal of Drug Targeting]

    Abstract

    INDUSTRY AND POLICY NEWS

    Algernon Announces First Patient Dosed in Phase II IPF and Chronic Cough Human Trial of Ifenprodil

    Algernon Pharmaceuticals Inc. announced that the first patient has been dosed in its Phase II idiopathic pulmonary fibrosis and chronic cough clinical study of its re-purposed drug NP-120.
    [Algernon Pharmaceuticals Inc. (GlobeNewswire, Inc.)]

    Press Release

    Rozlytrek, Roche’s First Tumor-Agnostic Therapy, Approved in Europe for People with NTRK Fusion-Positive Solid Tumors and for People with ROS1-Positive Advanced Non-Small Cell Lung Cancer

    Roche announced that the European Commission has granted conditional marketing authorization for Rozlytrek® for the treatment of adult and paediatric patients 12 years of age and older with solid tumors expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory treatment options.
    [F. Hoffmann-La Roche Ltd]

    Press Release

    FEATURED EVENT

    IASLC 2020 World Conference on Lung Cancer

    January 26 – January 29, 2021
    Singapore, Singapore

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professors – Respiratory Translational Research

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellowship – Computational Medicine of the Lungs

    Institute for Computational Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Research Fellow – Biology of Small Cell Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Fellow – Lung Cancer Biology

    Virginia Commonwealth University – Richmond, Virginia, United States

    > See All Jobs

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