Pulmonary Cell News Volume 9.32 | Aug 20 2020

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    Justin.choi
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    2020-08-20 | PULCN 9.32


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.32 – 20 August, 2020
    TOP STORY

    LncRNA
    KTN1-AS1 Promotes the Progression of Non-Small Cell Lung Cancer via Sponging of miR-130a-5p and Activation of PDPK1

    KTN1-AS1 knockdown inhibited cell growth and proliferation, increased apoptosis, and modulated the expression of cell cycle- and apoptosis-related proteins in non-small cell lung cancer cell lines and tumor xenografts in nude mice.
    [Oncogene]

    Abstract


    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    Inhaled
    Underground Subway Dusts May Stimulate Multiple Pathways of Cell Death Signals and Disrupt Immune Balance

    Researchers identified a toxic mechanism and the potential health effects of ambient dust in an underground subway station. At 24 hour exposure to human bronchial epithelial cells, dust located within autophagosome-like vacuoles, whereas a series of autophagic processes appeared to be blocked.
    [Environmental Research]

    Abstract

    Epigallocatechin
    Gallate Diminishes Cigarette Smoke-Induced Oxidative Stress, Lipid Peroxidation, and Inflammation in Human Bronchial Epithelial Cells

    Scientists found that EGCG treatment blocked cigarette smoke extract-induced oxidative stress as indicated by decreased production and accumulation of reactive oxygen species in airway epithelial cells.
    [Life Sciences]

    Abstract

    Rutin
    Loaded Liquid Crystalline Nanoparticles Inhibit Lipopolysaccharide Induced Oxidative Stress and Apoptosis in Bronchial Epithelial Cells In Vitro

    The authors investigated the beneficial effects of rutin-loaded liquid crystalline nanoparticles against lipopolysaccharide induced oxidative damage in human bronchial epithelial cells in vitro.
    [Toxicology in Vitro]

    Abstract

    Toxicity
    of Iron Nanoparticles towards Primary Cultures of Human Bronchial Epithelial Cells

    Investigators determined whether the exposure to a relatively low dose of well‐characterized iron‐rich nanoparticles might alter some critical toxicological endpoints in a relevant primary culture model of human bronchial epithelial cells.
    [Journal of Applied Toxicology]

    Abstract

    LUNG CANCER

    LINC00467
    Is Up-Regulated by TDG-Mediated Acetylation in Non-Small Cell Lung Cancer and Promotes Tumor Progression

    Researchers identified LINC00467 as the up-regulated lncRNA that was common significantly differentially expressed in non-small cell lung cancer and CRC tissues from the GEO database.
    [Oncogene]

    Abstract

    Peptide
    Fibrillar Assemblies Exhibit Membranolytic Effects and Anti-Metastatic Activity on Lung Cancer Cells

    Anti-metastatic activities of peptide fibrillar assemblies were demonstrated by in vitro inhibition of lung cancer cell migration and clonogenesis.
    [Biomacromolecules]

    Abstract

    Apelin
    Enhances Biological Functions in Lung Cancer A549 Cells by Downregulating Exosomal miR-15a-5p

    Investigators examined whether apelin enhanced proliferation and invasion ability of lung cancer cells via exosomal miRNA.
    [Carcinogenesis]

    Abstract

    Targeting PD-L1 in Non-Small Cell Lung Cancer Using CAR T Cells

    PD-L1-chimeric antigen receptor (CAR) T cells exhibited antigen-specific activation, cytokine production, and cytotoxic activity against PD-L1high non-small cell lung carcinoma cells and xenograft tumors.
    [Oncogenesis]

    Full Article

    Distinct
    Transcriptional Programs of SOX2 in Different Types of Small Cell Lung Cancers

    Researchers showed, using next-generation sequencing, that SOX2 expressed in the ASCL1-high small cell lung cancer subtype cell line was dependent on ASCL1, which is a lineage-specific transcriptional factor, and was involved in neuroendocrine differentiation and tumorigenesis.
    [Laboratory Investigation]

    Abstract

    PD-L1+
    Lung Cancer Stem Cells Modify the Metastatic Lymph-Node Immunomicroenvironment in NSCLC Patients

    The authors investigated correlations between PD-L1+ cancer stem cells, changes in T-cell phenotype in metastatic and non-metastatic lymph nodes and response to treatment.
    [Cancer Immunology Immunotherapy]

    Full Article

    T-Type
    Calcium Channel Antagonist, TTA-A2 Exhibits Anti-Cancer Properties in 3D Spheroids of A549, a Lung Adenocarcinoma Cell Line

    Scientists studied TTA-A2 and paclitaxel in lung adenocarcinoma cell line- A549, cancer cells and human embryonic kidney cell line- HEK 293, control cell, in their monolayer and spheroids forms for viability, proliferation, morphology change, migration, and invasion-after 48–96 hours of treatment.
    [Life Sciences]

    Abstract

    Cyclic
    Pentapeptide cRGDfK Enhances the Inhibitory Effect of Sunitinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Human Non-Small Cell Lung Cancer Cells

    Researchers evaluated the inhibitory effect of a tyrosine kinase inhibitor sunitinib and the integrin-αⅤβ3 targeted cyclic peptide (cRGDfK) on EMT in human lung cancer cells.
    [PLoS One]

    Full Article


    Optimizing in vitro lung models with Dr. Rachael Rayner.
    REVIEWS

    Therapeutic
    Potential and Challenges of Bitter Taste Receptors on Lung Cells

    The authors discuss recent developments in T2R biology and their role in cellular physiology and expand on the therapeutic potential of T2R agonists in treatment of asthma.
    [Current Opinion in Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Verona
    Pharma Initiates Multiple Dose Part of Phase II Clinical Trial with pMDI Formulation of Ensifentrine in COPD

    Verona Pharma plc announced the initiation of the second, multiple dose, part of a Phase II trial to evaluate the pressurized metered-dose inhaler formulation of ensifentrine in patients with moderate to severe chronic obstructive pulmonary disease.
    [Verona Pharma plc]

    Press Release

    Enterprise Therapeutics Doses First Subjects in Phase I Trial for First-in-Class Cystic Fibrosis Therapy ETD002

    Enterprise Therapeutics Ltd announced it has successfully dosed the first subjects in a Phase I trial for its novel inhaled cystic fibrosis therapy, ETD002.
    [Enterprise Therapeutics Ltd]

    Press Release

    Vasomune Receives a US $2.8 Million PRMRP Grant from the US Department of Defense to Develop AV-001 for the Treatment of ALI/ARDS of Any Cause, Including COVID-19

    Vasomune Therapeutics announced it has received a Peer-Reviewed Medical Research Program grant award effective August 1, 2020 for US $2.8 million from the US Department of Defense for the development AV-001 for the treatment of COVID-19-associated acute lung injury and acute respiratory distress syndrome.
    [Vasomune Therapeutics]

    Press Release

    FEATURED EVENT

    8th
    International Conference on Stem Cell Engineering 2021

    July 8 – July 10, 2021
    Boston, Massachusetts, United States


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Lung Regeneration and Pollution

    Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France

    Assistant Professors – Respiratory Translational Research

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellowship – Computational Medicine of the Lungs

    Institute for Computational Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Research Fellow – Biology of Small Cell Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    > See All Jobs

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