| Vol. 9.33 – 27 August, 2020 |
| |
|
|
| Single-cell RNA sequencing of metastatic lung cancer was performed using 49 clinical biopsies obtained from 30 patients before and during targeted therapy. [Cell] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Mechanistic investigations demonstrated that thioredoxin domain containing 5 (TXNDC5) promoted fibrogenesis by enhancing TGFβ1 signaling through direct binding with and stabilization of TGFBR1 in lung fibroblasts. [Nature Communications] |
|
|
|
| Researchers found long noncoding RNA (lncRNA) Hoxaas3 was up-regulated in the mouse model of BLM-induced pulmonary fibrosis and TGF-β1-induced fibrogenesis in lung fibroblasts. [Cell Death & Disease] |
| |
|
|
| To study roles for MYCN amplification in small cell lung cancer (SCLC) progression and chemoresistance, the authors developed a genetically engineered mouse model of MYCN-overexpressing SCLC. [Genes & Development] |
|
|
|
| Researchers demonstrated that LLC-Exo accelerated tumor growth along with a significant accumulation of MDSCs in mouse tumor model. [Oncogene] |
|
|
|
| By incorporating epithelial cell adhesion molecule (EpCAM) aptamer and validated delta-5-desaturase (D5D) siRNA into the innovative three way-junction RNA-nanoparticle, target specific accumulation and D5D knockdown were achieved in the lung cancer cell and mouse models. [Molecular Therapy-Nucleic Acids] |
|
|
|
| Investigators report that the traditional Chinese anticancer agent tubeimoside I, which is a potent inhibitor of autophagy, could promote mitochondria-associated apoptosis in lung cancer cells. [Cell Death & Disease] |
|
|
|
| Scientists explored agents to use in combination with alectinib to enhance the antitumor effect of alectinib against rearranged during transfection (RET)-fusion cells. [Cancer Biology & Therapy] |
|
|
|
| Researchers showed that in lung cancer, interaction between paxillin (PXN) and integrin β4 (ITGB4), components of the focal adhesion complex, contributed to cisplatin resistance. Knocking down PXN and ITGB4 attenuated cell growth and improved cisplatin sensitivity, both in 2D and 3D cultures. [iScience] |
|
|
|
|
| The authors review recent research findings on the role of long non-coding RNAs in drug resistance in non-small-cell lung cancer, highlighting their mechanisms of action. [Cancer Gene Therapy] |
|
|
|
|
| LUNGevity Foundation announced the launch of new longitudinal study in collaboration with the FDA Oncology Center of Excellence titled Understanding the lung cancer Patient ExperiEnce in the Real-world setting (Project PEER). [LUNGevity Foundation] |
|
|
|
| Laurent Pharmaceuticals Inc. announced that it has received approval from the FDA to start enrolling US patients in RESOLUTION, a multicentric Phase II randomized placebo-controlled trial testing once-a-day oral LAU-7b as a potential treatment against COVID-19 disease. [Laurent Pharmaceuticals Inc.] |
|
|
|
|
|
|
|
| The University of Southern California – Los Angeles, California, United States |
|
|
|
| NYU Langone Health – New York, New York, United States |
|
|
|
| Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France |
|
|
|
| Institute for Computational Medicine – Baltimore, Maryland, United States |
|
|
|
| Columbia University Medical Center – New York, New York, United States |
|
|
|
|