Pulmonary Cell News Volume 9.33 | Aug 27 2020

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    2020-08-27 | PULCN 9.33


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.33 – 27 August, 2020
    TOP STORY

    Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

    Single-cell RNA sequencing of metastatic lung cancer was performed using 49 clinical biopsies obtained from 30 patients before and during targeted therapy.
    [Cell]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Fibroblast-Enriched Endoplasmic Reticulum Protein TXNDC5 Promotes Pulmonary Fibrosis by Augmenting TGFβ Signaling through TGFBR1 Stabilization

    Mechanistic investigations demonstrated that thioredoxin domain containing 5 (TXNDC5) promoted fibrogenesis by enhancing TGFβ1 signaling through direct binding with and stabilization of TGFBR1 in lung fibroblasts.
    [Nature Communications]

    Full Article

    LncRNA Hoxaas3 Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-450b-5p to Regulate Runx1

    Researchers found long noncoding RNA (lncRNA) Hoxaas3 was up-regulated in the mouse model of BLM-induced pulmonary fibrosis and TGF-β1-induced fibrogenesis in lung fibroblasts.
    [Cell Death & Disease]

    Full Article

    MYCN Drives Chemoresistance in Small Cell Lung Cancer while USP7 Inhibition Can Restore Chemosensitivity

    To study roles for MYCN amplification in small cell lung cancer (SCLC) progression and chemoresistance, the authors developed a genetically engineered mouse model of MYCN-overexpressing SCLC.
    [Genes & Development]

    Abstract

    miR-21a in Exosomes from Lewis Lung Carcinoma Cells Accelerates Tumor Growth through Targeting PDCD4 to Enhance Expansion of Myeloid-Derived Suppressor Cells

    Researchers demonstrated that LLC-Exo accelerated tumor growth along with a significant accumulation of MDSCs in mouse tumor model.
    [Oncogene]

    Abstract

    EpCAM Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation

    By incorporating epithelial cell adhesion molecule (EpCAM) aptamer and validated delta-5-desaturase (D5D) siRNA into the innovative three way-junction RNA-nanoparticle, target specific accumulation and D5D knockdown were achieved in the lung cancer cell and mouse models.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    Tubeimoside I-Induced Lung Cancer Cell Death and the Underlying Crosstalk between Lysosomes and Mitochondria

    Investigators report that the traditional Chinese anticancer agent tubeimoside I, which is a potent inhibitor of autophagy, could promote mitochondria-associated apoptosis in lung cancer cells.
    [Cell Death & Disease]

    Full Article

    Enhanced Antitumor Effect of Alectinib in Combination with Cyclin-Dependent Kinase 4/6 Inhibitor against RET-Fusion–Positive Non-Small Cell Lung Cancer Cells

    Scientists explored agents to use in combination with alectinib to enhance the antitumor effect of alectinib against rearranged during transfection (RET)-fusion cells.
    [Cancer Biology & Therapy]

    Full Article

    A Non-Genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer

    Researchers showed that in lung cancer, interaction between paxillin (PXN) and integrin β4 (ITGB4), components of the focal adhesion complex, contributed to cisplatin resistance. Knocking down PXN and ITGB4 attenuated cell growth and improved cisplatin sensitivity, both in 2D and 3D cultures.
    [iScience]

    AbstractFull ArticleGraphical Abstract

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    REVIEWS

    Mechanisms of Drug Resistance Mediated by Long Non-Coding RNAs in Non-Small-Cell Lung Cancer

    The authors review recent research findings on the role of long non-coding RNAs in drug resistance in non-small-cell lung cancer, highlighting their mechanisms of action.
    [Cancer Gene Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    LUNGevity Launches Lung Cancer Patient Research Project in Collaboration with the FDA

    LUNGevity Foundation announced the launch of new longitudinal study in collaboration with the FDA Oncology Center of Excellence titled Understanding the lung cancer Patient ExperiEnce in the Real-world setting (Project PEER).
    [LUNGevity Foundation]

    Press Release

    Laurent Pharmaceuticals Receives Approval from FDA to initiate Its COVID-19 Phase II Clinical Trial in the United States

    Laurent Pharmaceuticals Inc. announced that it has received approval from the FDA to start enrolling US patients in RESOLUTION, a multicentric Phase II randomized placebo-controlled trial testing once-a-day oral LAU-7b as a potential treatment against COVID-19 disease.
    [Laurent Pharmaceuticals Inc.]

    Press Release

    FEATURED EVENT

    Cancer Research & Oncology 2020

    October 7 – 8
    Virtual

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    JOB OPPORTUNITIES

    Research Lab Tech III – Supervisor

    The University of Southern California – Los Angeles, California, United States

    Postdoctoral Positions – Signal Transduction

    NYU Langone Health – New York, New York, United States

    Postdoctoral Position – Lung Regeneration and Pollution

    Institut Mondor de Recherche Biom̩dicale (IMRB) РCreteil, France

    Postdoctoral Fellowship – Computational Medicine of the Lungs

    Institute for Computational Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    > See All Jobs

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