Pulmonary Cell News Volume 9.36 | Sep 17 2020

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    2020-09-17 | PULCN 9.36


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.36 – 17 September, 2020
    TOP STORY

    Transient IGF-1R Inhibition Combined with Osimertinib Eradicates AXL-Low Expressing
    EGFR
    Mutated Lung Cancer

    Scientists showed that while AXL-low expressing epidermal growth factor receptor mutated lung cancer (EGFRmut-LC) cells were more sensitive to osimertinib than AXL-high expressing EGFRmut-LC cells, a small population emerged osimertinib tolerant.
    [Nature Communications]

    Full Article


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    Translational
    Pharmacology of an Inhaled Small Molecule αvβ6 Integrin Inhibitor for Idiopathic Pulmonary Fibrosis

    Researchers report that GSK3008348 bound to αvβ6 with high affinity in human idiopathic pulmonary fibrosis lung and reduced downstream pro-fibrotic transforming growth factor-β signaling to normal levels. In human lung epithelial cells, GSK3008348 induced rapid internalization and lysosomal degradation of the αvβ6 integrin.
    [Nature Communications]

    Full Article

    Ionocytes
    and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells

    The authors collected nasal cells by brushing to determine ionocyte abundance. Nasal and bronchial cells were also expanded in vitro and reprogrammed to differentiated epithelia for morphological and functional studies.
    [Cells]

    Full Article

    Respiratory
    Syncytial Virus Infection‐Induced Mucus Secretion by Down‐Regulation of miR‐34b/c‐5p Expression in Airway Epithelial Cells

    Scientists identified the critical differential expression miRNAs that regulated the pathological response in RSV‐infected airway epithelial cells.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Transient
    Receptor Potential Ankyrin-1 (TRPA1) and Vanilloid-3 (TRPV3) Differentially Regulate Endoplasmic Reticulum Stress and Cytotoxicity in Human Lung Epithelial Cells following Pneumotoxic Wood Smoke Particle Exposure

    Researchers investigated the roles of TRPA1 and TRPV3 in regulating endoplasmic reticulum stress and cytotoxicity in human bronchial epithelial cells treated with pneumotoxic wood smoke particulate matter and chemical agonists of each channel.
    [Molecular Pharmacology]

    Abstract

    LUNG CANCER

    A Pro-Tumorigenic Secretory Pathway Activated by p53 Deficiency in Lung Adenocarcinoma

    Scientists showed that TP53 loss initiated a pharmacologically actionable secretory process that drove lung adenocarcinoma progression.
    [Journal of Clinical Investigation]

    AbstractFull Article
    Graphical Abstract

    Tumor
    Regression and Resistance Mechanisms upon CDK4 and RAF1 Inactivation in KRAS/P53 Mutant Lung Adenocarcinomas

    Concomitant CDK4 inactivation and RAF1 ablation prevented tumor progression and induced complete regression in 25% of KRAS/p53-driven advanced lung tumors, yet a significant percentage of those tumors that underwent partial regression retained a population of CDK4/RAF1-resistant cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Y
    Chromosome LncRNA Are Involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells

    Researchers identified a group of Y chromosome-expressed long non-coding RNA that were involved in male NSCLC radiation sensitivity.
    [Cancer Research]

    AbstractGraphical Abstract

    DRAM1
    Plays a Tumor Suppressor Role in NSCLC Cells by Promoting Lysosomal Degradation of EGFR

    Scientists confirmed that DNA damage-regulated autophagy modulator 1 (DRAM1) inhibited the growth, migration, and invasion of NSCLC cells in vitro.
    [Cell Death & Disease]

    Full Article

    MT1DP
    Loaded by Folate-Modified Liposomes Sensitizes Erastin-Induced Ferroptosis via Regulating miR-365a-3p/NRF2 Axis in Non-Small Cell Lung Cancer Cells

    Researchers found that ectopic expression of metallothionein 1D pseudogene (MT1DP) sensitized A549 and H1299 cells to erastin-induced ferroptosis through downregulation of nuclear factor erythroid 2-related factor 2 (NRF2); in addition, ectopic MT1DP upregulated malondialdehyde and reactive oxygen species levels, increased intracellular ferrous iron concentration, and reduced glutathione levels in cancer cells exposed to erastin, whereas downregulation of MT1DP showed the opposite effect.
    [Cell Death & Disease]

    Full Article

    Heat
    Shock Protein B8 Promotes Proliferation and Migration in Lung Adenocarcinoma A549 Cells by Maintaining Mitochondrial Function

    The authors clarified whether heat shock protein B8 could bring benefits to proliferation and migration of lung adenocarcinoma and its underlying mechanisms.
    [Molecular and Cellular Biology]

    Abstract

    Cellular
    Retinol Binding Protein 1 Transfection Reduces Proliferation and AKT-Related Gene Expression in H460 Non-Small Lung Cancer Cells

    Scientists investigated the effect of cellular retinol binding protein-1 (CRBP-1) transfection in the H460 human NSCLC cell line, normally not expressing CRBP-1.
    [Molecular Biology Reports]

    Full Article


    Grow Functional Airway Organoids with PneumaCult™
    REVIEWS

    The Role of the ECM in Lung Cancer Dormancy and Outgrowth

    The authors examine the role of the extracellular matrix and its associated factors in establishing a fertile soil from which individual tumor cells and micrometastases establish primary and secondary tumors. They focus on the role of the lung extracellular matrix in providing the architectural support for local metastases in lung cancer, and distant metastases in many solid tumors.
    [Frontiers in Oncology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Moderna
    and Vertex Establish New Collaboration to Treat Cystic Fibrosis Using Gene Editing

    Moderna, Inc. and Vertex Pharmaceuticals Incorporated announced a new strategic research collaboration and licensing agreement aimed at the discovery and development of lipid nanoparticles and mRNAs for the delivery of gene-editing therapies for the treatment of cystic fibrosis.
    [Moderna, Inc.]

    Press Release

    Halozyme Announces Poster Presentation of Data from Roche’s Phase Ib Study Evaluating Atezolizumab for Subcutaneous Administration Utilizing Enhanze® in Non-Small Cell Lung Cancer

    Halozyme Therapeutics, Inc. announced that its collaborator, Roche, presented a poster with data from Part 1 of its Phase Ib study evaluating atezolizumab for subcutaneous administration utilizing Halozyme’s ENHANZE® technology in patients with locally advanced or metastatic NSCLC.
    [Halozyme Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    International Chemical Biology Society (ICBS) 2020 Conference

    November 11 – 13
    Virtual


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    JOB OPPORTUNITIES

    Postdoctoral
    Research Associate – Acute Lung Injury

    Old Dominion University – Norfolk, Virginia, United States

    Postdoctoral
    Fellow – Parenchymal/Vascular Lung Disease

    Justus-Liebig-Universität Gießen – Gießen, Germany

    Postdoctoral
    Positions – Signal Transduction

    NYU Langone Health – New York, New York, United States

    Postdoctoral Position – Lung Regeneration and Pollution

    Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France

    Margaret
    Turner Warwick Chair of Thoracic Medicine – Fibrosing Lung Disease

    National Heart and Lung Institute – London, United Kingdom

    > See All Jobs

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