Pulmonary Cell News Volume 9.38 | Oct 1 2020

May 12, 2022

2020-01-10 | PULCN 9.38

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.38 – 1 October, 2020

TOP STORY

STAT3–BDNF–TrkB Signaling Promotes Alveolar Epithelial Regeneration after Lung Injury

Single-cell transcriptome analysis identified brain-derived neurotrophic factor as a STAT3 target gene with newly accessible chromatin in a unique population of regenerating AT2 cells.
[Nature Cell Biology]

Full Article

Virtual Conference Exhibition: Organoids

PUBLICATIONSRanked by the impact factor of the journal

Proteome-Wide
Effects of Naphthalene-Derived Secondary Organic Aerosol in BEAS-2B Cells Are Caused by Short-Lived Unsaturated Carbonyls

The authors investigated the dynamic toxicities of naphthalene-derived secondary organic aerosol in a human bronchial epithelial cell line and identified the chemical components responsible for toxicities.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

miR-184
Targets TP63 to Block Idiopathic Pulmonary Fibrosis by Inhibiting Proliferation and Epithelial–Mesenchymal Transition of Airway Epithelial Cells

Investigators showed abnormal upregulation of tumor protein p63 (TP63) and downregulation of miR-184 in idiopathic pulmonary fibrosis. Transforming growth factor beta 1 stimulation of BEAS-2B and A549 cell lines significantly increased the protein levels of Tp63, alpha-smooth muscle actin, and vimentin, but decreased EpCAM protein levels, and promoted viability of both BEAS-2B and A549 cell lines.
[Laboratory Investigation]

Full Article

PM014
Attenuates Radiation-Induced Pulmonary Fibrosis via Regulating NF-kB and TGF-b1/NOX4 Pathways

Scientists investigated the radioprotective effects and the underlying mechanism of the standardized herbal extract PM014 on radiation-induced lung fibrosis.
[Scientific Reports]

Full Article

Heterogeneous
Ozone Effects on the DNA Methylome of Bronchial Cells Observed in a Crossover Study

Researchers used a randomized crossover experiment to estimate the effects of ozone exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours.
[Scientific Reports]

Full Article

Hydrogen
Peroxide Causes Cell Death via Increased Transcription of HOXB13 in Human Lung Epithelial A549 Cells

Scientists studied the role of homeobox protein B13 (HOXB13) in cytotoxicity caused by hydrogen peroxide in human lung epithelial A549 cells. The knockdown of HOXB13 reduced hydrogen peroxide-induced cytotoxicity; however, this phenomenon was largely absent in the presence of antioxidants.
[Toxics]

Full Article

LUNG CANCER

Multilineage
Murine Stem Cells Generate Complex Organoids to Model Distal Lung Development and Disease

The authors established a three‐dimensional murine bronchioalveolar lung organoid model that allowed clonal expansion and self‐organization of FACS‐sorted bronchioalveolar stem cells upon co‐culture with lung‐resident mesenchymal cells.
[EMBO Journal]

Abstract Graphical Abstract

FGFR1
Is Critical for Rbl2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer

Researchers showed that increased fibroblast growth factor receptor 1 (FGFR1) promoted tumorigenic progression in precancerous neuroendocrine cells and was required for small cell lung cancer development in vivo.
[Cancer Research]

Abstract

MicroRNA-3613-5p
Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop

Scientists determined that microRNA-3613-5p plays a crucial role in RELA-mediated post-transcriptional regulation of lung adenocarcinoma cell proliferation.
[Molecular Therapy-Nucleic Acids]

Abstract Graphical Abstract

Bone
Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-193a Reduces Cisplatin Resistance of Non-Small Cell Lung Cancer Cells via Targeting LRRC1

A549 and H1299 cell lines were screened out and their parent cells and drug-resistant cells were co-cultured with human bone marrow mesenchymal stem cells-derived exosomes that had been transfected with miR-193a mimic or si-LRRC1 to detect the colony formation, migration, apoptosis, invasion and proliferation of non-small cell lung cancer cells.
[Cell Death & Disease]

Full Article

MicroRNA-130b
Functions as an Oncogene and Is a Predictive Marker of Poor Prognosis in Lung Adenocarcinoma

Researchers investigated the clinicopathologic significance of microRNA-130b in lung adenocarcinoma and analyzed its cancer-specific functions.
[Laboratory Investigation]

Abstract

Grow Functional Airway Organoids with PneumaCult™

REVIEWS

Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small-Cell Lung Cancer (NSCLC)

EGFR mutations are the most common oncogenic drivers in NSCLC. Significant developments have taken place which highlight the differences in tumor biology that exist between the mutant and wild-type subtypes of NSCLC.
[Pharmaceuticals]

Full Article

INDUSTRY AND POLICY NEWS

Windtree Announces FDA Acceptance of IND Application for a Phase II Clinical Trial Studying KL4 Surfactant in Acute Lung Injury in Adults with COVID-19

Windtree Therapeutics, Inc. announced that FDA has accepted its Investigational New Drug application for a Phase II clinical trial studying lyo lucinactant, its KL4 surfactant drug, in COVID-19 associated lung injury and acute respiratory distress syndrome patients.
[Windtree Therapeutics, Inc.]

Press Release

FDA
Approves KALYDECO^® (Ivacaftor) as First and Only CFTR Modulator to Treat Eligible Infants with CF as Early as Four Months of Age

Vertex Pharmaceuticals Incorporated announced the FDA approved KALYDECO^® for use in children with cystic fibrosis ages four months to less than six months old who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that is responsive to KALYDECO based on clinical and/or in vitro assay data.
[Vertex Pharmaceuticals Incorporated]

Press Release

FEATURED EVENT

STAT3–BDNF–TrkB Signaling Promotes Alveolar Epithelial Regeneration after Lung Injury

Proteome-Wide
Effects of Naphthalene-Derived Secondary Organic Aerosol in BEAS-2B Cells Are Caused by Short-Lived Unsaturated Carbonyls

miR-184
Targets TP63 to Block Idiopathic Pulmonary Fibrosis by Inhibiting Proliferation and Epithelial–Mesenchymal Transition of Airway Epithelial Cells

PM014
Attenuates Radiation-Induced Pulmonary Fibrosis via Regulating NF-kB and TGF-b1/NOX4 Pathways

Heterogeneous
Ozone Effects on the DNA Methylome of Bronchial Cells Observed in a Crossover Study

Hydrogen
Peroxide Causes Cell Death via Increased Transcription of HOXB13 in Human Lung Epithelial A549 Cells

Multilineage
Murine Stem Cells Generate Complex Organoids to Model Distal Lung Development and Disease

FGFR1
Is Critical for Rbl2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer

MicroRNA-3613-5p
Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop

Bone
Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-193a Reduces Cisplatin Resistance of Non-Small Cell Lung Cancer Cells via Targeting LRRC1

MicroRNA-130b
Functions as an Oncogene and Is a Predictive Marker of Poor Prognosis in Lung Adenocarcinoma

Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small-Cell Lung Cancer (NSCLC)

Windtree Announces FDA Acceptance of IND Application for a Phase II Clinical Trial Studying KL4 Surfactant in Acute Lung Injury in Adults with COVID-19

FDA
Approves KALYDECO^® (Ivacaftor) as First and Only CFTR Modulator to Treat Eligible Infants with CF as Early as Four Months of Age

Stem Cells and Cancer

> See All Events

Postdoctoral Fellow – Pharmacogenomics and Integrative Genomics

Postdoctoral
Research Associate – Acute Lung Injury

Postdoctoral
Positions – Signal Transduction

Postdoctoral Position – Lung Regeneration and Pollution

Margaret
Turner Warwick Chair of Thoracic Medicine – Fibrosing Lung Disease

> See All Jobs