Pulmonary Cell News Volume 9.39 | Oct 8 2020

May 12, 2022

2020-08-10 | PULCN 9.39

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.39 – 8 October, 2020

TOP STORY

In
Primary Airway Epithelial Cells, the Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition

Scientists triggered partial epithelial-to-mesenchymal transition or unjamming transition in differentiated primary human bronchial epithelial cells.
[Nature Communications]

Full Article

On-demand Webinar on Studying Cystic Fibrosis using Primary Human Nasal Epithelial Cells - Watch Now

PUBLICATIONSRanked by the impact factor of the journal

Fatty
Acid-Binding Protein 5 Limits ILC2-Mediated Allergic Lung Inflammation in a Murine Asthma Model

The authors examined the role of fatty acid-binding protein 5 (FABP5) in the allergic lung inflammation and demonstrated that the expression of FABP5 acts as a novel positive regulator of ST2 expression in alveolar epithelial cells (ECs) to generate retinoic acid (RA) and supports the synthesis of RA from type II alveolar ECs to suppress excessive activation of innate lymphoid cell 2 during allergic lung inflammation.
[Scientific Reports]

Full Article

Spred2-Deficiency
Enhances the Proliferation of Lung Epithelial Cells and Alleviates Pulmonary Fibrosis Induced by Bleomycin

Scientists examined the role of Sprouty-related EVH-1-domain-containing protein (Spred) 2, a negative regulator of the MAPK-ERK pathway, in the development of bleomycin-induced pulmonary fibrosis.
[Scientific Reports]

Full Article

Improved Detection of Tumor Suppressor Events in Single-Cell RNA-Seq Data

Researchers identified NKX2-1 and TBX4 inactivation as early tumor suppressor events in normal non-ciliated lung epithelial cells from smokers.
[NPJ Genomic Medicine]

Full Article

LUNG CANCER

Transcriptional
Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma

75% of adenocarcinomas lack targeted therapies due to scarcity of druggable drivers. The authors classified tumors based on signaling similarities and discovered subgroups within this unmet patient population.
[Clinical Cancer Research]

Abstract

Thymidylate
Synthase Drives the Phenotypes of Epithelial-to-Mesenchymal Transition in Non-Small Cell Lung Cancer

Investigators established a functional correlation between thymidylate synthase (TS), epithelial-to-mesenchymal transition (EMT), chemotherapy and metastasis and propose a network for TS mediated EMT.
[British Journal of Cancer]

Full Article Graphical Abstract

The
Cross-Talk between Methylation and Phosphorylation in Lymphoid-Specific Helicase Drives Cancer Stem-Like Properties

Researchers showed that the accumulation of phosphorylation of lymphoid-specific helicase (LSH) at S503 site exhibited downregulation of LSH methylation at R309 residue, which eventually promoted stem-like properties in lung cancer.
[Signal Transduction and Targeted Therapy]

Full Article

Small
GTPase RAB6 Deficiency Promotes Alveolar Progenitor Cell Renewal and Attenuates PM2.5-Induced Lung Injury and Fibrosis

Investigators demonstrated that knockout of RAB6 inhibited pulmonary fibrosis, oxidative stress, and type 2 alveolar epithelial cells (AEC2) cell death in fine particulate matter (PM2.5)-injured mice. In addition, knockout of RAB6 decreased Dickkopf 1 autocrine and activated proliferation, self-renewal, and wnt/β-catenin signaling of PM2.5-injured AEC2 cells.
[Cell Death & Disease]

Full Article

Prognostic
Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma

Scientists aimed to establish a prognostic prediction model for lung adenocarcinoma (LUAD) patients based on a metabolism-associated gene signature. Differentially expressed metabolism-associated genes were screened from The Cancer Genome Atlas LUAD cohorts.
[Molecular Therapy-Oncolytics]

Abstract Graphical Abstract

ARHGEF19
Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer

Enforced ARHGEF19 expression promoted small cell lung cancer cell proliferation in vitro and its knockdown decreased cell proliferation in vitro and in vivo.
[Biochemical and Biophysical Research Communications]

Abstract

An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.

REVIEWS

Combination
Therapy with PD-1/PD-L1 Blockade in Non-Small Cell Lung Cancer: Strategies and Mechanisms

The authors discuss the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade in combination with conventional chemotherapy, targeted therapy or immunotherapy. Meanwhile, they illustrate their underlying mechanisms in regulating the process of the cancer-immunity cycle, providing the rationale for the PD-1/PD-L1 blockade-based combination therapy.
[Pharmacology & Therapeutics]

Abstract

INDUSTRY AND POLICY NEWS

Opdivo (Nivolumab) Plus Chemotherapy Shows Statistically Significant Improvement in Pathologic Complete Response as Neoadjuvant Treatment of Resectable Non-Small Cell Lung Cancer in Phase III CheckMate -816 Trial

Bristol Myers Squibb announced that the Phase III CheckMate-816 trial met a primary endpoint of pathologic complete response in resectable non-small cell lung cancer.
[Bristol Myers Squibb]

Press Release

Amgen Announces Positive Topline Phase II Results For Investigational KRAS G12C Inhibitor Sotorasib In Advanced Non-Small Cell Lung Cancer

Amgen announced positive topline Phase II results from the CodeBreaK 100 clinical study, evaluating sotorasib in 126 patients with KRAS G12C-mutant advanced non-small cell lung cancer, who had failed a median of two prior lines of anti-cancer therapies.
[Amgen]

Press Release

Enterprise Therapeutics’ First-in-Class TMEM16A Potentiator Program for Treatment of Cystic Fibrosis and Other Respiratory Diseases Acquired by Roche

Enterprise Therapeutics Ltd. announced its novel TMEM16A potentiator portfolio has been fully acquired by Roche and will be developed by Genentech.
[Enterprise Therapeutics Ltd.]

Press Release

FEATURED EVENT

In
Primary Airway Epithelial Cells, the Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition

Fatty
Acid-Binding Protein 5 Limits ILC2-Mediated Allergic Lung Inflammation in a Murine Asthma Model

Spred2-Deficiency
Enhances the Proliferation of Lung Epithelial Cells and Alleviates Pulmonary Fibrosis Induced by Bleomycin

Improved Detection of Tumor Suppressor Events in Single-Cell RNA-Seq Data

Transcriptional
Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma

Thymidylate
Synthase Drives the Phenotypes of Epithelial-to-Mesenchymal Transition in Non-Small Cell Lung Cancer

The
Cross-Talk between Methylation and Phosphorylation in Lymphoid-Specific Helicase Drives Cancer Stem-Like Properties

Small
GTPase RAB6 Deficiency Promotes Alveolar Progenitor Cell Renewal and Attenuates PM2.5-Induced Lung Injury and Fibrosis

Prognostic
Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma

ARHGEF19
Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer

Combination
Therapy with PD-1/PD-L1 Blockade in Non-Small Cell Lung Cancer: Strategies and Mechanisms

Opdivo (Nivolumab) Plus Chemotherapy Shows Statistically Significant Improvement in Pathologic Complete Response as Neoadjuvant Treatment of Resectable Non-Small Cell Lung Cancer in Phase III CheckMate -816 Trial

Amgen Announces Positive Topline Phase II Results For Investigational KRAS G12C Inhibitor Sotorasib In Advanced Non-Small Cell Lung Cancer

Enterprise Therapeutics’ First-in-Class TMEM16A Potentiator Program for Treatment of Cystic Fibrosis and Other Respiratory Diseases Acquired by Roche

The
Evolving Tumor Microenvironment In Cancer Progression: Mechanisms And Emerging Therapeutic Opportunities

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Assistant
Professor – Respirologist

Postdoctoral Fellow – Pharmacogenomics and Integrative Genomics

Postdoctoral
Research Associate – Acute Lung Injury

Postdoctoral
Positions – Signal Transduction

Margaret
Turner Warwick Chair of Thoracic Medicine – Fibrosing Lung Disease

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