Pulmonary Cell News Volume 9.41 | Oct 22 2020

May 12, 2022

2020-22-10 | PULCN 9.41

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.41 – 22 October, 2020

TOP STORY

Human
Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2 Mediated Interferon Responses and Pneumocyte Dysfunction

The authors report a feeder-free, scalable, chemically-defined, and modular alveolosphere culture system for propagation and differentiation of human alveolar type 2 cells/pneumocytes derived from primary lung tissue.
[Cell Stem Cell]

Abstract Press Release
Graphical Abstract

Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Three-Dimensional
Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2

Researchers developed a feeder-free, long-term three-dimensional culture technique for human lung alveolar type 2 cells derived from primary human lung tissue, and investigate infection response to SARS-CoV-2.
[Cell Stem Cell]

Abstract Editorial
Graphical Abstract

Expression
of SARS-CoV-2 Entry Factors in Lung Epithelial Stem Cells and Its Potential Implications for COVID-19

Scientists analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2.
[Scientific Reports]

Full Article

LUNG CANCER

PLCγ1
Suppression Promotes the Adaptation of KRAS-Mutant Lung Adenocarcinomas to Hypoxia

Using a lipidomic screen, scientists found that PLCγ1 was suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines.
[Nature Cell Biology]

Abstract

Guanosine
Triphosphate Links MYC-Dependent Metabolic and Ribosome Programs in Small Cell Lung Cancer

Investigators demonstrated that primary MYC^High human small cell lung cancer tumors contain abundant guanosine nucleotides.
[Journal of Clinical Investigation]

Abstract Full Article

CHIP-Mediated
CIB1 Ubiquitination Regulated Epithelial–Mesenchymal Transition and Tumor Metastasis in Lung Adenocarcinoma

The expression levels of CIB1 in lung adenocarcinoma tissues and adjacent normal tissues were examined by immunohistochemistry, and the relationship between CIB1 expression and patient clinicopathological characteristics was analyzed.
[Cell Death & Differentiation]

Full Article

SCLC-CellMiner:
A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

The authors demonstrated the reproducibility and stability of data from multiple sources and validate the small cell lung cancer (SCLC) consensus nomenclature on the basis of expression of master transcription factors NEUROD1, ASCL1, POU2F3, and YAP1.
[Cell Reports]

Full Article Graphical Abstract

S6K1
Blockade Overcomes Acquired Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer

The role of S6K1 in tyrosine kinase inhibitor resistance was determined in in vitro gain-and-loss of function studies and confirmed in subcutaneous and orthotopic mouse lung cancer models.
[Oncogene]

Full Article

Discovery
of a Novel EGFR Ligand DPBA that Degrades EGFR and Suppresses EGFR-Positive NSCLC Growth

The authors identified a 23-hydroxybetulinic acid derivative, namely DPBA, as a novel epidermal growth factor receptor (EGFR) small-molecule ligand. It exerted potent in vitro and in vivo anticancer activity in both EGFR wild type and mutant non-small cell lung cancer by degrading EGFR.
[Signal Transduction and Targeted Therapy]

Full Article

Importin
13 Promotes NSCLC Progression by Mediating RFPL3 Nuclear Translocation and hTERT Expression Upregulation

Scientists identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
[Cell Death & Disease]

Full Article

Consequences of Zmat3 Loss in c-MYC– and Mutant KRAS-Driven
Tumorigenesis

To investigate which oncogenic drivers co-operate with Zmat3 loss to promote neoplastic transformation, researchers utilized Zmat3 knockout mice in models of c-MYC-driven lymphomagenesis and KrasG12D-driven lung adenocarcinoma development.
[Cell Death & Disease]

Full Article

Aberrant
Super-Enhancer Landscape Reveals Core Transcriptional Regulatory Circuitry in Lung Adenocarcinoma

By integrating profiles of H3K27Ac chromatin immunoprecipitation sequencing from normal adult lung and lung adenocarcinoma cell lines, investigators revealed that widespread alterations of the super-enhancer were present during lung carcinogenesis.
[Oncogenesis]

Full Article

Cancer-Testis
Antigens, Semenogelins 1 and 2, Exhibit Different Anti-Proliferative Effects on Human Lung Adenocarcinoma Cells

Scientists demonstrated that semenogelins 1 and 2 exhibit different patterns of expression and sub-cellular localization in non-small cell lung cancer cell lines.
[Cell Death Discovery]

Full Article

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REVIEWS

Epithelial
Stem and Progenitor Cells in Lung Repair and Regeneration

The authors focus on the regionally distinct lung epithelial cell types that contribute to repair after injury, and they address current controversies regarding whether elite stem cells or frequent facultative progenitors are the predominant participants.
[Annual Review of Physiology]

Abstract

INDUSTRY AND POLICY NEWS

Galera
Therapeutics Announces Dosing of First Patient in the Phase I/II GRECO-1 Clinical Trial of GC4711 in Combination with SBRT for Non-Small Cell Lung Cancer

Galera Therapeutics, Inc. announced that the first patient has been dosed in the Phase I/II GRECO-1 clinical trial of GC4711 in combination with stereotactic body radiation therapy in patients with non-small cell lung cancer.
[Galera Therapeutics, Inc.]

Press Release

Tagrisso
Granted Priority Review in the US for the Adjuvant Treatment of Patients with Early-Stage EGFR-Mutated Lung Cancer

AstraZeneca’s Tagrisso has received acceptance for its supplemental New Drug Application and has also been granted Priority Review in the US for the adjuvant treatment of patients with early-stage epidermal growth factor receptor-mutated non-small cell lung cancer after complete tumour resection with curative intent.
[AstraZeneca]

Press Release

FEATURED EVENT

Human
Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2 Mediated Interferon Responses and Pneumocyte Dysfunction

Three-Dimensional
Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2

Expression
of SARS-CoV-2 Entry Factors in Lung Epithelial Stem Cells and Its Potential Implications for COVID-19

PLCγ1
Suppression Promotes the Adaptation of KRAS-Mutant Lung Adenocarcinomas to Hypoxia

Guanosine
Triphosphate Links MYC-Dependent Metabolic and Ribosome Programs in Small Cell Lung Cancer

CHIP-Mediated
CIB1 Ubiquitination Regulated Epithelial–Mesenchymal Transition and Tumor Metastasis in Lung Adenocarcinoma

SCLC-CellMiner:
A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

S6K1
Blockade Overcomes Acquired Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer

Discovery
of a Novel EGFR Ligand DPBA that Degrades EGFR and Suppresses EGFR-Positive NSCLC Growth

Importin
13 Promotes NSCLC Progression by Mediating RFPL3 Nuclear Translocation and hTERT Expression Upregulation

Consequences of Zmat3 Loss in c-MYC– and Mutant KRAS-Driven
Tumorigenesis

Aberrant
Super-Enhancer Landscape Reveals Core Transcriptional Regulatory Circuitry in Lung Adenocarcinoma

Cancer-Testis
Antigens, Semenogelins 1 and 2, Exhibit Different Anti-Proliferative Effects on Human Lung Adenocarcinoma Cells

Epithelial
Stem and Progenitor Cells in Lung Repair and Regeneration

Galera
Therapeutics Announces Dosing of First Patient in the Phase I/II GRECO-1 Clinical Trial of GC4711 in Combination with SBRT for Non-Small Cell Lung Cancer

Tagrisso
Granted Priority Review in the US for the Adjuvant Treatment of Patients with Early-Stage EGFR-Mutated Lung Cancer

Keystone
Symposia: Tumor Metabolism and the Microenvironment

> See All Events

Faculty
Position – Oncology & Lung Cancer

Postdoctoral
Fellow – Parenchymal/Vascular Lung Disease

Assistant
Professor – Respirologist

Postdoctoral Fellow – Pharmacogenomics and Integrative Genomics

Postdoctoral
Research Associate – Acute Lung Injury

> See All Jobs