Pulmonary Cell News Volume 9.43 | Nov 5 2020

May 12, 2022

2020-05-11 | PULCN 9.43

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.43 – 5 November, 2020

TOP STORY

Rev7
Loss Alters Cisplatin Response and Increases Drug Efficacy in Chemotherapy-Resistant Lung Cancer

Scientists examined whether targeting Rev7, a component of the translesion synthesis machinery, could potentiate the action of cisplatin in NSCLC treatment.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Short
Exposure to Hyperoxia Causes Cultured Lung Epithelial Cell Mitochondrial Dysregulation and Alveolar Simplification in Mice

The authors investigated the role of a very short exposure to hyperoxia on mitochondrial function in cultured mouse lung epithelial cells and neonatal mice.
[Pediatric Research]

Abstract

Cysteinyl Leukotriene D₄ (LTD₄)
Promotes Airway Epithelial Cell Inflammation and Remodeling

Using primary human small airway epithelial cells, researchers investigated the mechanism of leukotriene D₄-induced inflammation and remodeling and assessed high proneness of obese mice to develop asthma upon challenge with allergen ovalbumin.
[Inflammation Research]

Abstract

Transcriptomic
Analysis of Key Genes and Pathways in Human Bronchial Epithelial Cells BEAS-2B Exposed to Urban Particulate Matter

Human bronchial epithelial cells BEAS-2B were exposed to standard reference material 1649b, followed by RNA-sequencing and a combination of different bioinformatics analysis.
[Environmental Science and Pollution Research]

Abstract

Additive
Effects of Simulated Microgravity and Ionizing Radiation in Cell Death, Induction of ROS and Expression of RAC2 in Human Bronchial Epithelial Cells

Human lung bronchial epithelial Beas-2B cells were used to study the regulation of radiobiological effects by simulated microgravity. It was found that simulated microgravity together with radiation induced drop of survival fraction, proliferation inhibition, apoptosis, and DNA double-strand break formation of Beas-2B cells additively.
[NPJ Microgravity]

Full Article

LUNG CANCER

KPNB1-Mediated
Nuclear Translocation of PD-L1 Promotes Non-Small Cell Lung Cancer Cell Proliferation via the Gas6/MerTK Signaling Pathway

Scientists demonstrated that programmed cell death ligand 1 (PD-L1) expression levels were positively correlated with p-MerTK levels in patient samples and NSCLC cell lines.
[Cell Death & Differentiation]

Full Article

GDC-0349 Inhibits Non-Small Cell Lung Cancer Cell Growth

In A549 cells and primary human NSCLC cells, GDC-0349 inhibited cell growth, proliferation, cell cycle progression, migration and invasion, while inducing significant apoptosis activation.
[Cell Death & Disease]

Full Article

LncRNA
LINC00472 Regulates Cell Stiffness and Inhibits the Migration and Invasion of Lung Adenocarcinoma by Binding to YBX1

LINC00472 inhibited lung adenocarcinoma cell migration and invasion and increased cell stiffness and adhesion. RNA pull down and RIP assays identified that LINC00472 interacted with the transcription factor Y-box binding protein 1, which partially reversed the inhibition of cell migration and invasion and increased LINC00472-induced cell stiffness and adhesion.
[Cell Death & Disease]

Full Article

Therapeutic Potential of Polysaccharide of
Ipomoea batatas as an Autophagy Inducer for Treating Lung Cancer via Blocking PAK1/Akt/mTOR Signaling

Researchers identified a role of Ipomoea batatas polysaccharides (IBP) in inhibiting lung cancer proliferation. They found that IBP significantly impeded the proliferation of lung cancer cells by inducing cytostatic macroautophagy both in vitro and in vivo.
[Molecular Therapy-Oncolytics]

Abstract Graphical Abstract

Combinations
of Proteasome Inhibitors with Obatoclax Are Effective for Small Cell Lung Cancer

The authors investigated whether bortezomib or carfilzomib combined with obatoclax, an antagonist for MCL-1 and a pan-BCL family inhibitor, could cause synergistic growth inhibition of small cell lung cancer cells.
[Acta Pharmacologica Sinica]

Abstract

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REVIEWS

Human
Pluripotent Stem Cell‐Derived Lung Organoids: Potential Applications in Development and Disease Modeling

Scientists discuss the advantages and pitfalls of human pluripotent stem cell‐derived lung 2D and 3D models, including the main characteristics and potentials for these models and their current and future applications for modeling development and diseases.
[Wiley Interdisciplinary Reviews-Developmental Biology]

Abstract Graphical Abstract

INDUSTRY AND POLICY NEWS

Calithera
Biosciences Awarded Up To $2.4M from Cystic Fibrosis Foundation to Support Clinical Development of Arginase Inhibitor, CB-280

Calithera Biosciences, Inc. has been awarded up to $2.4M from the Cystic Fibrosis Foundation. The award will support clinical development of CB-280, Calithera’s investigational first-in-class arginase inhibitor, which promotes higher tissue levels of nitric oxide to reduce the risk of infections in people with cystic fibrosis.
[Calithera Biosciences, Inc.]

Press Release

Vertex
Announces European Commission Approval for KALYDECO^® (Ivacaftor) as First and Only CFTR Modulator to Treat Eligible Infants with Cystic Fibrosis as Early as Four Months of Age

Vertex Pharmaceuticals Incorporated announced that the European Commission has granted approval of the label extension for KALYDECO^® granules to include the treatment of infants with cystic fibrosis.
[Vertex Pharmaceuticals Incorporated]

Press Release

FEATURED EVENT

Rev7
Loss Alters Cisplatin Response and Increases Drug Efficacy in Chemotherapy-Resistant Lung Cancer

Short
Exposure to Hyperoxia Causes Cultured Lung Epithelial Cell Mitochondrial Dysregulation and Alveolar Simplification in Mice

Cysteinyl Leukotriene D₄ (LTD₄)
Promotes Airway Epithelial Cell Inflammation and Remodeling

Transcriptomic
Analysis of Key Genes and Pathways in Human Bronchial Epithelial Cells BEAS-2B Exposed to Urban Particulate Matter

Additive
Effects of Simulated Microgravity and Ionizing Radiation in Cell Death, Induction of ROS and Expression of RAC2 in Human Bronchial Epithelial Cells

KPNB1-Mediated
Nuclear Translocation of PD-L1 Promotes Non-Small Cell Lung Cancer Cell Proliferation via the Gas6/MerTK Signaling Pathway

GDC-0349 Inhibits Non-Small Cell Lung Cancer Cell Growth

LncRNA
LINC00472 Regulates Cell Stiffness and Inhibits the Migration and Invasion of Lung Adenocarcinoma by Binding to YBX1

Therapeutic Potential of Polysaccharide of
Ipomoea batatas as an Autophagy Inducer for Treating Lung Cancer via Blocking PAK1/Akt/mTOR Signaling

Combinations
of Proteasome Inhibitors with Obatoclax Are Effective for Small Cell Lung Cancer

Human
Pluripotent Stem Cell‐Derived Lung Organoids: Potential Applications in Development and Disease Modeling

Calithera
Biosciences Awarded Up To $2.4M from Cystic Fibrosis Foundation to Support Clinical Development of Arginase Inhibitor, CB-280

Vertex
Announces European Commission Approval for KALYDECO^® (Ivacaftor) as First and Only CFTR Modulator to Treat Eligible Infants with Cystic Fibrosis as Early as Four Months of Age

The American Association for Cancer Research (AACR) Annual Meeting 2021

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Faculty
Position – Oncology & Lung Cancer

Postdoctoral
Fellow – Parenchymal/Vascular Lung Disease

Assistant
Professor – Respirologist

Postdoctoral Fellow – Pharmacogenomics and Integrative Genomics

Postdoctoral
Research Associate – Acute Lung Injury

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