Pulmonary Cell News Volume 9.45 | Nov 19 2020

May 12, 2022

2020-11-19 | PULCN 9.45

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.45 – 19 November, 2020

TOP STORY

Engineered
Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fibrosis–Based Cell and Mice Models

Researchers inhibited endogenous heterotrimeric ENaC channels by introducing inactivating mutant ENaC α mRNA.
[Science Advances]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

Scutellarin
Ameliorates Pulmonary Fibrosis through Inhibiting NF-κB/NLRP3-Mediated Epithelial–Mesenchymal Transition and Inflammation

Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]

Full Article

SARS-CoV-2
Receptor Is Co-Expressed with Elements of the Kinin–Kallikrein, Renin–Angiotensin and Coagulation Systems in Alveolar Cells

Researchers assembled a healthy human lung cell atlas meta-analysis with ~ 130,000 public single-cell transcriptomes and showed that key elements of the bradykinin, angiotensin and coagulation systems were co-expressed with angiotensin converting enzyme-2 (ACE2) in alveolar cells and associated with their differentiation dynamics, which could explain how changes in ACE2 promoted by SARS-CoV-2 cell entry result in the development of the three most severe clinical components of COVID-19.
[Scientific Reports]

Full Article

ADAM17 Deficiency Protects against Pulmonary Emphysema

Histological, immunohistochemical, immunofluorescence and molecular analyses, as well as lung function tests, were performed to assess pulmonary emphysema, inflammation and alveolar cell apoptosis.
[American Journal of Respiratory Cell and Molecular Biology]

Abstract

Altered
Transcriptional and Chromatin Responses to Rhinovirus in Bronchial Epithelial Cells from Adults with Asthma

Scientists demonstrated that cultured primary bronchial epithelial cells from adults with asthma showed different transcriptional and chromatin responses to rhinovirus infection compared to those without asthma.
[Communications Biology]

Full Article

LUNG CANCER

AMG
757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer

AMG 757 efficacy was evaluated in small cell lung cancer (SCLC) cell lines and in orthotopic and patient-derived xenograft mouse SCLC models. Following AMG 757 administration, changes in tumor volume, pharmacodynamic changes in tumor-infiltrating T cells (TILs), and the spatial relationship between the appearance of TILs and tumor histology were examined. Tolerability was assessed in nonhuman primates.
[Clinical Cancer Research]

Abstract

OTUD7B
Suppresses Smac Mimetic-Induced Lung Cancer Cell Invasion and Migration via Deubiquitinating TRAF3

Scientists assessed lung cancer cell elongation, invasion and migration under treatment with the Smac mimetic LCL161. Functional analyses were performed to detect the contribution of NIK and OTUD7B to LCL161-induced cell invasion and migration. The role of OTUD7B in regulation of the TRAF3/NIK/NF-κB pathway under LCL161 treatment was analysed by immunoblotting, immunoprecipitation, luciferase and ubiquitin assays, shRNA silencing and plasmid overexpression.
[Journal of Experimental & Clinical Cancer Research]

Full Article

A Fusion of CD63–BCAR4
Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]

Full Article

TGFβ Promotes YAP‐Dependent AXL
Induction in Mesenchymal‐Type Lung Cancer Cells

Researchers revealed that the YAP signature, which was highly enriched in mesenchymal‐type lung cancer, was closely correlated to AXL expression in 181 lung cancer cell lines. Moreover, using isogenic lung cancer cell pairs, they also found that doxorubicin treatment induced YAP nuclear translocation in mesenchymal‐type lung cancer cells to induce AXL expression.
[Molecular Oncology]

Abstract

On-demand Webinar on Studying Cystic Fibrosis using Primary Human Nasal Epithelial Cells - Watch Now

REVIEWS

CRISPR-Cas
Deployment in Non-small Cell Lung Cancer for Target Screening, Validations, and Discoveries

The authors review the application of CRISPR-Cas in non-small cell lung cancer (NSCLC) for development of mutant models, drug screening, target validation, novel target discoveries, and other emerging potential applications
[Cancer Gene Therapy]

Abstract

INDUSTRY AND POLICY NEWS

BeiGene
Announces that RATIONALE 303 Trial of Tislelizumab in Non-Small Cell Lung Cancer Met the Primary Endpoint of Overall Survival at Interim Analysis

BeiGene, Ltd. announced that the RATIONALE 303 trial of its anti-PD-1 antibody tislelizumab versus docetaxel in the second- or third-line setting in patients with locally advanced or metastatic non-small cell lung cancer who progressed on prior platinum-based chemotherapy, met its primary endpoint of overall survival in the intention-to-treat patient population at the planned interim analysis.
[Beigene Ltd.]

Press Release

FEATURED EVENT

Engineered
Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fibrosis–Based Cell and Mice Models

Scutellarin
Ameliorates Pulmonary Fibrosis through Inhibiting NF-κB/NLRP3-Mediated Epithelial–Mesenchymal Transition and Inflammation

SARS-CoV-2
Receptor Is Co-Expressed with Elements of the Kinin–Kallikrein, Renin–Angiotensin and Coagulation Systems in Alveolar Cells

ADAM17 Deficiency Protects against Pulmonary Emphysema

Altered
Transcriptional and Chromatin Responses to Rhinovirus in Bronchial Epithelial Cells from Adults with Asthma

AMG
757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer

OTUD7B
Suppresses Smac Mimetic-Induced Lung Cancer Cell Invasion and Migration via Deubiquitinating TRAF3

A Fusion of CD63–BCAR4
Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

TGFβ Promotes YAP‐Dependent AXL
Induction in Mesenchymal‐Type Lung Cancer Cells

CRISPR-Cas
Deployment in Non-small Cell Lung Cancer for Target Screening, Validations, and Discoveries

BeiGene
Announces that RATIONALE 303 Trial of Tislelizumab in Non-Small Cell Lung Cancer Met the Primary Endpoint of Overall Survival at Interim Analysis

The
Evolving Tumor Microenvironment In Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities

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Postdoctoral Research Associate – Idiopathic Pulmonary Fibrosis

Postdoctoral Research Position and PhD Position – Cardiovascular and Lung Diseases

Faculty
Position – Oncology & Lung Cancer

Assistant
Professor – Respirologist

Postdoctoral Fellow – Pharmacogenomics and Integrative Genomics

> See All Jobs