Pulmonary Cell News Volume 9.47 | Dec 3 2020

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    2020-03-12 | PULCN 9.47


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.47 – 3 December, 2020
    TOP STORY

    The Hexosamine Biosynthesis Pathway Is a Targetable Liability in KRAS/LKB1 Mutant Lung Cancer

    Glutamine-fructose-6-phosphate transaminase 2 inhibition selectively reduced KRAS/LKB1 co-mutant tumor cell growth in culture, xenografts and genetically modified mice.
    [Nature Metabolism]

    Abstract

    Tools and products for your COVID-19 research.
    PUBLICATIONSRanked by the impact factor of the journal

    Interleukin-28B Dampens Protease-Induced Lung Inflammation via IL-25 and TSLP Inhibition in Epithelial Cells

    Investigators used plant-derived cysteine protease, papain to induce asthma in mice and found that interleukin (IL)-28B was capable of alleviating papain-induced asthma. Papain challenge led to activation of epithelial cells and production of alarmin, such as IL-25 and thymic stromal lymphopoietin and IL-28B treatment down-regulated their production.
    [Scientific Reports]

    Full Article

    Salidroside Regulates Inflammatory Pathway of Alveolar Macrophages by Influencing the Secretion of miRNA-146a Exosomes by Lung Epithelial Cells

    Scientists explored the investigative mechanism of salidroside on LPS-induced acute lung injury/acute respiratory distress syndrome.
    [Scientific Reports]

    Full Article

    Inhibiting the Reproduction of SARS-CoV-2 through Perturbations in Human Lung Cell Metabolic Network

    Researchers used genomic and structural information to create a biomass function capturing the amino and nucleic acid requirements of SARS-CoV-2. Incorporating this biomass function into a stoichiometric metabolic model of the human lung cell and applying metabolic flux balance analysis, they identified host-based metabolic perturbations inhibiting SARS-CoV-2 reproduction.
    [Life Science Alliance]

    Full ArticlePress Release

    CCL7 Recruits cDC1 to Promote Antitumor Immunity and Facilitate Checkpoint Immunotherapy to Non-Small Cell Lung Cancer

    Investigators demonstrated that CCL7 facilitates anti-PD-1 therapy for the KrasLSL−G12D/+Tp53fl/fl and the KrasLSL−G12D/+Lkb1fl/fl non-small cell lung cancer mouse models by recruiting conventional DC 1 (cDC1) into the tumor microenvironment to promote T cell expansion.
    [Nature Communications]

    Full Article

    Concurrent Mutations in TK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

    The authors investigated the effects of coordinate STK11 and KEAP1 loss by comparing co-mutant with single mutant and wild-type isogenic counterparts in multiple lung adenocarcinoma models.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    CBL0137 Increases the Targeting Efficacy of Rovalpituzumab Tesirine against Tumor-Initiating Cells in Small Cell Lung Cancer

    Researchers investigated the potential effect of combining Rovalpituzumab tesirine and CBL0137 in small cell lung cancer to eradicate tumor-initiating cells more effectively.
    [British Journal of Cancer]

    Abstract

    MELK Is an Oncogenic Kinase Essential for Metastasis, Mitotic Progression, and Programmed Death in Lung Carcinoma

    Knockdown of MELK expression inhibits the migration and invasion of lung adenocarcinoma (LUAD) cells, which may be mediated by Twist1, Slug, MMP7, and N-catenin. Overexpression of MELK promoted the growth of LUAD cells in medium, 3D Matrigel, and nude mice.
    [Signal Transduction and Targeted Therapy]

    Full Article

    SKIL Facilitates Tumorigenesis and Immune Escape of NSCLC via Upregulating TAZ/Autophagy Axis

    The authors investigated roles of SKIL in tumorigenesis and immune escape of non-small-cell lung cancer (NSCLC). SKIL expression levels in NSCLC cell line, clinical sample, and adjacent normal tissue were measured by quantitative PCR, western blot, or immunohistochemistry.
    [Cell Death & Disease]

    Full Article

    A Novel Circular RNA, circXPO1, Promotes Lung Adenocarcinoma Progression by Interacting with IGF2BP1

    Investigators characterized a novel circular RNA, circXPO1, in lung adenocarcinoma, which was derived from a well-established cancer therapeutic target, XPO1.
    [Cell Death & Disease]

    Full Article

    Studying COVID-19 with ALI culture
    REVIEWS

    Interleukin-11 Signaling Underlies Fibrosis, Parenchymal Dysfunction, and Chronic Inflammation of the Airway

    Initially thought of as a protective cytokine, interleukin-11 is now increasingly recognized as an important determinant of lung fibrosis, inflammation, and epithelial dysfunction.
    [Experimental and Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Ipsen Receives FDA Fast Track Designation for Investigational Irinotecan Liposome Injection (ONIVYDE®) as a Second-Line Monotherapy Treatment for Small Cell Lung Cancer (SCLC)

    Ipsen announced the FDA has granted the company Fast Track designation for irinotecan liposome injection in study patients with SCLC who progressed following a first-line platinum-based regimen, reflecting the unmet medical need.
    [Ipsen]

    Press Release

    FEATURED EVENT

    Stem Cells and Cancer

    May 16 – May 21, 2021
    Lucca, Italy

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Tissue Engineering of the Lung

    Columbia University – New York, New York, United States

    Research Assistant – Asthma Research

    Philipps-Universität Marburg – Marburg, Germany

    Postdoctoral Fellow Position – Host-Pathogen Interactions

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Fellowship – Pro-Metastatic Tumor Microenvironment

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Faculty Position – Oncology & Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    > See All Jobs

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