Pulmonary Cell News Volume 9.49 | Dec 17 2020

May 12, 2022

2020-17-12 | PULCN 9.49

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.49 – 17 December, 2020

TOP STORY

Secretory
Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia

Researchers identified the cell types that contribute to CFTR expression and function within the proximal-distal axis of the normal human lung. Single cell RNA-seq was performed on freshly isolated human large and small airway epithelial cells.
[American Journal of Respiratory and Critical Care Medicine]

Abstract

Grow Functional Airway Organoids with PneumaCult™

PUBLICATIONSRanked by the impact factor of the journal

Alveolar
Epithelial Cell‐Derived Sonic Hedgehog Promotes Pulmonary Fibrosis through OPN‐Dependent Alternative Macrophage Activation

Scientists investigated the interaction between macrophages and fibrosis‐associated alveolar epithelial cells using a bleomycin‐induced mouse pulmonary fibrosis model and a co‐culture system.
[FEBS Journal]

Abstract

Outer Membrane Vesicles Derived from Klebsiella pneumoniae
Influence the miRNA Expression Profile in Human Bronchial Epithelial BEAS-2B Cells

miRNA expression profiles in human bronchial epithelial cells were evaluated during infection with standard and clinical K. pneumoniae strains.
[Microorganisms]

Full Article

K_2P2.1
(TREK-1) Potassium Channel Activation Protects against Hyperoxia-Induced Lung Injury

Investigators treated hyperoxia-exposed mice and primary alveolar epithelial cells with the novel TREK-1 activators ML335 and BL1249, and quantified physiological, histological, and biochemical lung injury markers.
[Scientific Reports]

Full Article

LUNG CANCER

LKB1
Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition

The authors investigated the association between alterations in STK11/LKB1, the second most common tumor suppressor in NSCLC, and response to radiotherapy as well as potential therapeutic approaches to improve outcomes.
[Clinical Cancer Research]

Abstract

Sequential Ubiquitination of p53 by TRIM28, RLIM, and MDM2 in Lung Tumorigenesis

The stable overexpression of tripartite motif-containing 28 (TRIM28) in lung cancer cells and xenograft models significantly increased the proliferation, migration, and invasiveness, whereas knockdown of TRIM28 had the opposite effect.
[Cell Death & Differentiation]

Abstract

Cigarette
Smoke-Induced LKB1/AMPK Pathway Deficiency Reduces EGFR TKI Sensitivity in NSCLC

Investigators report that exposure to cigarette smoke extract enhances glycolysis and attenuates AMP-activated protein kinase-dependent inhibition of mTOR; this in turn reduces the sensitivity of non-small cell lung cancer cells with wild-type EGFR to EGFR TKI by repressing expression of liver kinase B1, a master kinase of the AMPK subfamily, via CpG island methylation.
[Oncogene]

Full Article

Linc00426
Accelerates Lung Adenocarcinoma Progression by Regulating miR-455-5p as a Molecular Sponge

The deregulation of Linc00426 contributed to a notable impairment in proliferation, invasion, metastasis, and epithelial–mesenchymal transition in vitro and in vivo.
[Cell Death & Disease]

Full Article

The
Novel Rexinoid MSU-42011 Is Effective for the Treatment of Preclinical Kras-Driven Lung Cancer

Investigators used MSU-42011 to treat established tumors in a clinically relevant Kras-driven mouse model of lung cancer.
[Scientific Reports]

Full Article

Albanol
B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth

Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]

Full Article

Explore scientific events this January with the Science Events Calendar.

REVIEWS

Monoclonal Antibodies and Airway Diseases

The authors focus on the physiological and pathomechanisms of monoclonal antibodies, and they present recent study results regarding their use as a therapeutic option against severe airway diseases.
[International Journal of Molecular Sciences]

Full Article

INDUSTRY AND POLICY NEWS

Veracyte
Announces Expansion of Collaboration with the Lung Cancer Initiative at Johnson & Johnson

Veracyte, Inc. announced it has expanded its long-term strategic collaboration with the Lung Cancer Initiative at Johnson & Johnson. The collaboration will include a focus on the NOBLE trial, a 9,000-patient, prospective, multicenter clinical study designed to distinguish genomic and other differences in lung cancer development and progression among patients with lung nodules detected by CT imaging.
[Veracyte, Inc.]

Press Release

Amgen Submits Sotorasib New Drug Application to US FDA for Advanced or Metastatic Non-Small Cell Lung Cancer with KRAS G12C Mutation

Amgen announced submission of a New Drug Application to the for sotorasib, an investigational KRAS^G12C inhibitor for the treatment of patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer, as determined by an FDA-approved test, following at least one prior systemic therapy.
[Amgen]

Press Release

FEATURED EVENT

Secretory
Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia

Alveolar
Epithelial Cell‐Derived Sonic Hedgehog Promotes Pulmonary Fibrosis through OPN‐Dependent Alternative Macrophage Activation

Outer Membrane Vesicles Derived from Klebsiella pneumoniae
Influence the miRNA Expression Profile in Human Bronchial Epithelial BEAS-2B Cells

K_2P2.1
(TREK-1) Potassium Channel Activation Protects against Hyperoxia-Induced Lung Injury

LKB1
Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition

Sequential Ubiquitination of p53 by TRIM28, RLIM, and MDM2 in Lung Tumorigenesis

Cigarette
Smoke-Induced LKB1/AMPK Pathway Deficiency Reduces EGFR TKI Sensitivity in NSCLC

Linc00426
Accelerates Lung Adenocarcinoma Progression by Regulating miR-455-5p as a Molecular Sponge

The
Novel Rexinoid MSU-42011 Is Effective for the Treatment of Preclinical Kras-Driven Lung Cancer

Albanol
B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth

Monoclonal Antibodies and Airway Diseases

Veracyte
Announces Expansion of Collaboration with the Lung Cancer Initiative at Johnson & Johnson

Amgen Submits Sotorasib New Drug Application to US FDA for Advanced or Metastatic Non-Small Cell Lung Cancer with KRAS G12C Mutation

ISSCR: Vision 2030 A Forecast for the Field

> See All Events

Postdoctoral Research Scientist – Tissue Engineering of the Lung

Research
Assistant – Asthma Research

Postdoctoral Fellow Position – Host-Pathogen Interactions

Postdoctoral
Fellowship – Pro-Metastatic Tumor Microenvironment

Faculty
Position – Oncology & Lung Cancer

> See All Jobs