Umbilical & Placental Cell News Volume 14.18 | May 12 2022

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    2022-05-12 | UPCN 14.18


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    Vol. 14.18 – 12 May, 2022
    TOP STORY

    A Genome-Wide CRISPR-Cas9 Knockout Screen Identifies Essential and Growth-Restricting Genes in Human Trophoblast Stem Cells

    The authors utilized a genome-wide CRISPR-Cas9 knockout screen to comprehensively identify essential and growth-restricting genes in human trophoblast stem cells.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Induction of Human Trophoblast Stem-Like Cells from Primed Pluripotent Stem Cells

    Scientists reported that trophoblast stem-like cells could be generated from human primed pluripotent stem cells by a short-term treatment of bone morphogenetic protein 4 without amnion lineage marker expression.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Molecular Regulation of Trophoblast Stem Cell Self-Renewal and Giant Cell Differentiation by the Hippo Components YAP and LATS1

    Trophoblast giant cell differentiation was associated with cytoplasmic retention of YAP, heightened pYAPSer127, decrease in the level of the core Hippo component, LATS1, which thereby impeded LATS1-LIMK2 association.
    [Stem Cell Research & Therapy]

    Full Article

    Improved Outcomes of Single-Unit Cord Blood Transplantation for Acute Myeloid Leukemia by Killer Immunoglobulin-Like Receptor 2DL1-Ligand Mismatch

    To investigate their role in acute myeloid leukemia, mismatch of KIR2DL1, KIR3DL1, and KIR3DL2-ligand were retrospectively assessed in patients undergoing cord blood transplantation with graft-versus-host disease prophylaxis comprising a calcineurin inhibitor plus methotrexate or mycophenolate mofetil.
    [Bone Marrow Transplantation]

    Abstract

    Conditioned Medium from Amniotic Fluid Mesenchymal Stem Cells Could Modulate Alzheimer’s Disease-Like Changes in Human Neuroblastoma Cell Line SY-SY5Y in a Paracrine Manner

    Researchers investigated the paracrine effect of amniotic fluid-derived mesenchymal stem cells on Alzheimer’s disease changes in human SH–SY5Y cells.
    [Tissue and Cell]

    Abstract

    Overexpression of lncRNA HCP5 in Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promoted the Proliferation and Inhibited the Apoptosis of Ovarian Granulosa Cells via the Musashi RNA-Binding Protein 2/Oestrogen Receptor Alpha 1 Axis

    Human umbilical cord MSC-derived exosomes promoted the proliferation of ovarian granulosa cells and estrogen receptor alpha 1 expression and inhibited cell apoptosis.
    [Endocrine Journal]

    Abstract

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    REVIEWS

    Umbilical Hernia Repair in Patients with Cirrhosis: Who, When and How to Treat

    Scientists provide an overview of crucial elements in the treatment of patients with cirrhosis and umbilical hernia.
    [Hernia]

    Abstract

    INDUSTRY AND POLICY NEWS

    Therapeutic Solutions International Announces Launching of Phase III Clinical Trial for Treating COVID-19 Lung Damage Using Its JadiCell™ Universal Donor Stem Cell Drug

    Therapeutic Solutions International, Inc. announced filing of an IND and FDA seeking permission to treat 10 patients with advanced COPD using its universal donor adult stem cell product termed “JadiCell™”.
    [Therapeutic Solutions International, Inc. (BioSpace)]

    Press Release

    FEATURED EVENT

    European Hematology Association (EHA) 2022

    June 9 – 12, 2022
    Vienna, Austria & Online

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Computational Biology

    Harvard Medical School – Boston, Massachusetts, United States

    Scientist – Fetal Cells in Maternal Blood

    Luna Genetics, Inc. – Houston, Texas, United States

    Tenure Track Faculty Position – Cell Signaling

    New York University College of Dentistry – New York, New York, United States

    Lab Scientist – Tissue and Cellular Therapy

    The University of Iowa – Iowa City, Iowa, United States

    Postdoctoral Fellow – Single-Cell Genomics of Human Development

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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