Umbilical & Placental Cell News Volume 14.16 | Apr 28 2022

April 28, 2022

2022-04-28 | CBN 14.16

Cord Blood News by STEMCELL Technologies

Vol. 14.16 – 28 April, 2022

TOP STORY

Human Placental Proteomics and Exon Variant Studies Link AAT/SERPINA1 with Spontaneous Preterm Birth

Researchers analyzed the proteomes from placentas to identify proteins that associate with both gestational age and spontaneous labor.
[BMC Medicine]

Full Article

REVIEWS

MicroRNA-146a-5p-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Diabetic Nephropathy in Rats through Facilitating M2 Macrophage Polarization

The authors attempted to determine the protective effects and underlying mechanisms of human umbilical cord-derived MSCs on streptozotocin-induced diabetic nephropathy.
[Stem Cell Research & Therapy]

Full Article

Impact of Consolidative Unrelated Cord Blood Transplantation on Clinical Outcomes of Patients with Relapsed/Refractory Acute B Lymphoblastic Leukemia Entering Remission Following CD19 Chimeric Antigen Receptor T Cells

Scientists reviewed 53 patients with relapsed/refractory B cell acute lymphoblastic leukemia successfully infused with CD19 CAR-T cells and achieved complete remission.
[Frontiers in Immunology]

Full Article

The First Reported Generation of Footprint-Free Human Induced Pluripotent Stem Cell Line (SCIKFi001-a) in Indonesia from cGMP Grade Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) Using Synthetic Self-Replicating RNA

Investigators showed that umbilical cord-MSCs could be reprogrammed to induced pluripotent stem cells using a safer and more regulatory friendly method, which ccould enable researchers to accelerate their clinical development timeline.
[Stem Cell Research]

Full Article

Pro-Angiognetic and Pro-Osteogenic Effects of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-21-5p in Osteonecrosis of the Femoral Head

Researchers uncovered the role of miR-21-5p shuttled by human umbilical MSC-derived exosomes, in promoting angiogenesis and osteogenesis, which may be a potential therapeutic target for osteonecrosis of the femoral head.
[Cell Death Discovery]

Full Article

Human Amniotic Fluid Stem Cells Can Alleviate Detrusor Dysfunction Caused by Bladder Outlet Obstruction in Rats

The authors examined whether bladder detrusor dysfunction due to partial bladder outlet obstruction could be improved after the treatment of human amniotic fluid stem cells.
[Scientific Reports]

Full Article

Topical Spray of Wharton’s Jelly Mesenchymal Stem Cells Derived from Umbilical Cord Accelerates Diabetic Wound Healing

Three days after the induction of diabetes, a circular excision was created on the back of rats. Diabetic rats were divided into two groups: control and Wharton’s jelly-MSCs group.
[Journal of Cosmetic Dermatology]

Abstract

Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.

REVIEWS

Current Understanding in Deciphering Trophoblast Cell Differentiation during Human Placentation

Investigators summarize the current understanding of human placental trophoblast differentiation and the molecules that govern trophoblast cell lineage specification.
[Biology of Reproduction]

Abstract

Metabolic Pathways Utilized by the Porcine Conceptus, Uterus, and Placenta

Conceptus elongation and early placentation involve growth and remodeling that requires proliferation and migration of cells.
[Molecular Reproduction and Development]

Full Article

INDUSTRY AND POLICY NEWS

Institute for the Biology of Stem Cells Awarded $1M Training Grant for Postdoctoral Researchers

With the new award, Institute for the Biology of Stem Cells directors Camilla Forsberg and Lindsay Hinck have now brought in nearly $12 million to fund the future of bimolecular research at UC Santa Cruz.
[UC Santa Cruz]

Press Release

FEATURED EVENT

Umbilical & Placental Cell News Volume 14.16 | Apr 28 2022

Human Placental Proteomics and Exon Variant Studies Link AAT/SERPINA1 with Spontaneous Preterm Birth

MicroRNA-146a-5p-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Diabetic Nephropathy in Rats through Facilitating M2 Macrophage Polarization

Impact of Consolidative Unrelated Cord Blood Transplantation on Clinical Outcomes of Patients with Relapsed/Refractory Acute B Lymphoblastic Leukemia Entering Remission Following CD19 Chimeric Antigen Receptor T Cells

The First Reported Generation of Footprint-Free Human Induced Pluripotent Stem Cell Line (SCIKFi001-a) in Indonesia from cGMP Grade Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) Using Synthetic Self-Replicating RNA

Pro-Angiognetic and Pro-Osteogenic Effects of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-21-5p in Osteonecrosis of the Femoral Head

Human Amniotic Fluid Stem Cells Can Alleviate Detrusor Dysfunction Caused by Bladder Outlet Obstruction in Rats

Topical Spray of Wharton’s Jelly Mesenchymal Stem Cells Derived from Umbilical Cord Accelerates Diabetic Wound Healing

Current Understanding in Deciphering Trophoblast Cell Differentiation during Human Placentation

Metabolic Pathways Utilized by the Porcine Conceptus, Uterus, and Placenta

Institute for the Biology of Stem Cells Awarded $1M Training Grant for Postdoctoral Researchers

ISCT – JSTCT Joint Session at the 44th JSTCT Annual Meeting (JSTCT 2022)

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Tenure Track Faculty Position – Cell Signaling

Research Scientist – Bone Marrow Niche

Lab Scientist – Tissue and Cellular Therapy

Postdoctoral Fellow – Single-Cell Genomics of Human Development

Research Engineer – Bioprinted Tissue Therapeutics

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