Umbilical & Placental Cell News Volume 14.17 | May 5 2022

May 5, 2022

2022-05-05 | UPCN 14.17

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Vol. 14.17 – 5 May, 2022

TOP STORY

VE-Cadherin Enables Trophoblast Endovascular Invasion and Spiral Artery Remodeling during Placental Development

Scientists showed that the vascular endothelial (VE)-cadherin was required for trophoblast migration and endovascular invasion into the maternal decidua in the mouse.
[eLife]

Abstract

PUBLICATIONSRanked by the impact factor of the journal

Maternal Prenatal Depressive Symptoms and Toddler Behavior: An Umbilical Cord Blood Epigenome-Wide Association Study

Researchers investigated DNA methylation in cord blood to identify possible “at birth” signatures that may indicate susceptibility to behavioral problems at 18 months of age.
[Translational Psychiatry]

Full Article

HIF1A Promotes miR-210/miR-424 Transcription to Modulate the Angiogenesis in HUVECs and HDMECs via sFLT1 under Hypoxic Stress

HIF1A is a key regulato of the recovery of intracellular homeostasis under hypoxia. Scientists investigated the detailed role and mechanism of HIF1A in the angiogenesis under hypoxia.
[Molecular & Cellular Proteomics]

Abstract

Quercetin Regulates Vascular Endothelium Function in Chronic Renal Failure via Modulation of Eph/Cav-1 Signaling

The authors uncovered the impacts of Quercetin on vascular endothelial cells in a chronic renal failure (CRF) rat model and human umbilical vein endothelial cells stimulated by lipopolysaccharide and serum from rat with CRF.
[Drug Development Research]

Abstract

MicroRNA-140-5p from Human Umbilical Cord Mesenchymal Stem Cells–Released Exosomes Suppresses Preeclampsia Development

Exosomes (EXO) were isolated from human umbilical cord-MSCs. Hypoxic trophoblast cells were co-cultured with huc-MSCs–released EXO.
[Functional & integrative Genomics]

Abstract

The Endocannabinoids Anandamide and 2-Arachidonoylglycerol Modulate the Expression of Angiogenic Factors on HTR8/SVneo Placental Cells

Using the human extravillous trophoblast (EVT) HTR-8/SVneo cells, a well-accepted model of first trimester EVT, researchers aimed to investigate whether endocannabinoids anandamide and 2-arachidonoylglycerol could modulate the expression of angiogenesis- and invasion-related factors.
[Prostaglandins Leukotrienes and Essential Fatty Acids]

Abstract

Placental Transfusion during Neonatal Resuscitation in an Asphyxiated Preterm Model

Cord milking with ventilation led to higher red cell volume than other interventions. Ventilation during cord milking reduced fluctuation in carotid flow compared to umbilical cord milking alone.
[Pediatric Research]

Abstract

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REVIEWS

Placental Tissues as Biomaterials in Regenerative Medicine

The development and compositions of each of birth tissues are reviewed, with focus on the structural and signaling components that are relevant to medical applications.
[Biomed Research International]

Full Article

INDUSTRY AND POLICY NEWS

Vitti Labs Announces FDA Approval of Phase II IND Clinical Trial of Combination Mesenchymal Stem Cell and Exosome Treatment of Pulmonary Fibrosis Secondary to Novel Corona Virus Infection (COVID-19)

Vitti Labs announced that the FDA approved their Investigational New Drug Application to move forward with Phase II Outpatient Clinical Trial using a combination of umbilical cord MSCs and MSC Exosomes for the treatment of pulmonary fibrosis secondary to COVID-19.
[Vitti Labs (Yahoo! Finance)]

Press Release

Accelerated Biosciences and Pluristyx Announce Availability of Human Trophoblast Stem Cell (hTSC) Derived iPSCs

Accelerated Biosciences announced an agreement for Pluristyx, Inc. to provide iPSCs derived from hTSCs procured under Good Tissue Practices for research evaluation.
[Accelerated Biosciences (BioSpace, Inc.)]

Press Release

FEATURED EVENT

Umbilical & Placental Cell News Volume 14.17 | May 5 2022

VE-Cadherin Enables Trophoblast Endovascular Invasion and Spiral Artery Remodeling during Placental Development

Maternal Prenatal Depressive Symptoms and Toddler Behavior: An Umbilical Cord Blood Epigenome-Wide Association Study

HIF1A Promotes miR-210/miR-424 Transcription to Modulate the Angiogenesis in HUVECs and HDMECs via sFLT1 under Hypoxic Stress

Quercetin Regulates Vascular Endothelium Function in Chronic Renal Failure via Modulation of Eph/Cav-1 Signaling

MicroRNA-140-5p from Human Umbilical Cord Mesenchymal Stem Cells–Released Exosomes Suppresses Preeclampsia Development

The Endocannabinoids Anandamide and 2-Arachidonoylglycerol Modulate the Expression of Angiogenic Factors on HTR8/SVneo Placental Cells

Placental Transfusion during Neonatal Resuscitation in an Asphyxiated Preterm Model

Placental Tissues as Biomaterials in Regenerative Medicine

Vitti Labs Announces FDA Approval of Phase II IND Clinical Trial of Combination Mesenchymal Stem Cell and Exosome Treatment of Pulmonary Fibrosis Secondary to Novel Corona Virus Infection (COVID-19)

Accelerated Biosciences and Pluristyx Announce Availability of Human Trophoblast Stem Cell (hTSC) Derived iPSCs

Gene Therapy Development & Manufacturing

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Scientist – Fetal Cells in Maternal Blood

Tenure Track Faculty Position – Cell Signaling

Lab Scientist – Tissue and Cellular Therapy

Postdoctoral Fellow – Single-Cell Genomics of Human Development

Research Engineer – Bioprinted Tissue Therapeutics

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