Umbilical & Placental Cell News Volume 14.19 | May 25 2022

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    2022-05-26 | UPCN 14.19


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    Vol. 14.19 – 26 May, 2022
    TOP STORY

    Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes That Drive Cellular Aging

    Investigators found that the epigenetic de-repression unlocked the expression of pregnancy-specific beta-1 glycoprotein genes that exacerbate human mesenchymal progenitor cells aging and serve as potential aging biomarkers.
    [Developmental Cell]

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    PUBLICATIONSRanked by the impact factor of the journal

    Improved Trends in Survival and Engraftment after Single Cord Blood Transplantation for Adult Acute Myeloid Leukemia

    To investigate the trends of survival and engraftment after cord blood transplantation (CBT) over the past 22 years, scientists retrospectively evaluated the data of patients with acute myeloid leukemia in Japan according to the time period of CBT.
    [Blood Cancer Journal]

    Full Article

    Durable Discontinuation of Systemic Therapy in Patients Affected by Chronic Graft-versus-Host Disease

    Researchers evaluated the factors associated with durable systemic therapy (ST) discontinuation, defined as cessation of all ST for ≥12 months, using data from two prospectively followed cohorts from the chronic graft-versus-host disease Consortium.
    [Haematologica]

    Abstract

    An Injectable Gelatin/Sericin Hydrogel Loaded with Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Uterine Injury

    A methacrylate gelatin and methacrylate sericin hydrogel with human umbilical cord mesenchymal stem cells encapsulation was designed for facilitating endometrial regeneration and fertility restoration through in situ injection.
    [Bioengineering & Translational Medicine]

    Full Article

    Derivation of Functional Trophoblast Stem Cells from Primed Human Pluripotent Stem Cells

    Scientists showed that the trophoblast cells cells resembled placenta- and naive human PSC-derived trophoblast stem cells, based on their transcriptome as well as their in vitro and in vivo differentiation potential.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    The Product of BMP-Directed Differentiation Protocols for Human Primed Pluripotent Stem Cells Is Placental Trophoblast and Not Amnion

    By analyzing transcriptome data from multiple sources, including bulk and single-cell data, investigators showed that the BMP4 procedure generated bona fide trophoblast (TB) with similarities to both placental villous TB and TB generated from TB stem cells.
    [Stem Cell Reports]

    Full Article
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    The Circadian Clock Has Roles in Mesenchymal Stem Cell Fate Decision

    Scientists focus on the close relationship between the circadian clock and MSC l fate decisions in the skeletal system.
    [Stem Cell Research & Therapy]

    Full Article

    Irisin and the Fibronectin Type III Domain-Containing Family: Structure, Signaling and Role in Female Reproduction

    The receptors for irisin are integrins, and it has recently been shown to alter steroidogenesis in ovarian granulosa cells although the effects appear to be species or context specific, and irisin may improve uterine and placental function in women and rodent models.
    [Reproduction]

    Full Article
    INDUSTRY AND POLICY NEWS

    Japan Tries—Again—to Revitalize Its Research

    Alarmed by the declining stature of its universities, Japan is planning to shower up to $2.3 billion a year on a handful of schools in hopes of boosting their prominence.
    [ScienceInsider]

    Press Release
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    JOB OPPORTUNITIES

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