Umbilical & Placental Cell News Volume 14.21 | June 9 2022

Vol. 14.22 – 9 June, 2022 TOP STORY Autophagy is Impaired in Fetal Hypoplastic Lungs and Rescued by Administration of Amniotic Fluid Stem Cell Extracellular Vesicles Scientists showed that amniotic fluid stem cell extracellular vesicle treatment rescued branching morphogenesis partly by restoring autophagy through miRNA cargo transfer. [American Journal of Respiratory and Critical Care Medicine] Abstract PUBLICATIONSRanked by the impact factor of the journal Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia Researchers found that nebulization of MSC-derived exosomes did not induce acute allergic or secondary allergic reactions but did promote the absorption of pulmonary lesions and reduced the duration of hospitalization for mild cases of COVID-19 pneumonia. [Stem Cell Reviews and Reports] Full ArticleGraphical Abstract Human Amniotic Mesenchymal Stem Cells-Derived IGFBP-3, DKK-3, and DKK-1 attenuate Liver Fibrosis through Inhibiting Hepatic Stellate Cell Activation by Blocking Wnt/β-Catenin Signaling Pathway in Mice Human amniotic MSCs (hAMSCs) were transplanted into carbon tetrachloride-induced liver fibrosis mice via tail vein, and the effects of hAMSCs on hepatic fibrosis were assessed. [Stem Cell Research & Therapy] Full Article Human Amniotic Fluid Mesenchymal Stem Cells Attenuate Pancreatic Cancer Cell Proliferation and Tumor Growth in an Orthotopic Xenograft Mouse Model Investigators demonstrated that human amniotic fluid mesenchymal stem cells strongly inhibit pancreatic ductal adenocarcinoma cell proliferation, tumor growth and invasion, possibly by altering cell cycle arrest and matrix metallopeptidase 7 signaling-triggered epithelial-mesenchymal transition. [Stem Cell Research & Therapy] Full Article Hyperthermia Increases HSP Production in Human PDMCs by Stimulating ROS Formation, p38 MAPK and Akt Signaling, and Increasing HSF1 Activity Scientists demonstrated that heat shock acted via reactive oxygen species (ROS) to activate p38 MAPK and Akt signaling, which subsequently activated heat shock factor 1 (HSF1), leading to heat shock protein (HSP) activation and contributing to the protective role of human placenta-derived multipotent cells (hPDMCs). [Stem Cell Research & Therapy] Full Article Tanshinone IIA Increased Amniotic Fluid Volume Through Down-Regulating Placental AQPs Expression via Inhibiting the Activity of GSK-3β The authors showed that compared with the women with normal amniotic fluid volume, placental aquaporins 1 (AQP1), AQP3, AQP8, and AQP9 protein expressions were decreased in women with idiopathic oligohydramnios. [Cell and Tissue Research] Abstract Human Placenta Mesenchymal Stem Cell-Derived Exosome Shuttling MicroRNA-130b-3p from Gestational Diabetes Mellitus Patients Targets ICAM-1 and Perturbs Human Umbilical Vein Endothelial Cell Angiogenesis Human placenta MSCs from gestational diabetes mellitus patients derived exosomes shuttling miR-130b-3p repressed proliferation, migration, and angiogenesis of human umbilical vein endothelial cells by regulating ICAM-1 expression. [Acta Diabetologica] Abstract REVIEWS Potential and Challenges of Placenta-Derived Decidua Stromal Cell Therapy in Inflammation-Associated Disorders The authors present decidual stromal cells functions in creating the anti-inflammatory environment, their immunomodulatory effects, and their advantages over MSCs. [Human Immunology] Abstract INDUSTRY AND POLICY NEWS Gamida Cell Completes Rolling Biologics License Application Submission to the FDA for Omidubicel Gamida Cell Ltd. announced completion of the rolling Biologics License Application submission to the US FDA for omidubicel for the treatment of patients with blood cancers in need of an allogenic hematopoietic stem cell transplant. [Gamida Cell, Ltd.] Press Release FEATURED EVENT Danish Stem Cell Society (DASCS) 2022 September 19 – 20, 2022 Vejle, Denmark > See All Events JOB OPPORTUNITIES Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism Van Andel Institute – Grand Rapids, Michigan, United States Postdoctoral Position – Computational Biology Harvard Medical School – Boston, Massachusetts, United States Tenure Track Faculty Position – Cell Signaling New York University College of Dentistry – New York, New York, United States Postdoctoral Fellow – Microenvironment and Signaling Albert Einstein College of Medicine – New York, New York, United States Scientist – Fetal Cells in Maternal Blood Luna Genetics, Inc. – Houston, Texas, United States > See All Jobs Brought to you by Science News Umbilical & Placental Cell News Archives Contact Us

On Thu, Jun 9, 2022 at 3:46 PM Nick Lee wrote:

Vol. 14.18 – 09 June, 2022 TOP STORY Autophagy is Impaired in Fetal Hypoplastic Lungs and Rescued by Administration of Amniotic Fluid Stem Cell Extracellular Vesicles Scientists showed that amniotic fluid stem cell extracellular vesicle treatment rescues branching morphogenesis partly by restoring autophagy through miRNA cargo transfer. [American Journal of Respiratory and Critical Care Medicine] Abstract PUBLICATIONSRanked by the impact factor of the journal Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia Researchers found that nebulization of mesenchymal stem cell-derived exosomes did not induce acute allergic or secondary allergic reactions but did promote the absorption of pulmonary lesions and reduce the duration of hospitalization for mild cases of COVID-19 pneumonia. [Stem Cell Reviews and Reports] Full ArticleGraphical Abstract Human Amniotic Mesenchymal Stem Cells-Derived IGFBP-3, DKK-3, and DKK-1 attenuate Liver Fibrosis through Inhibiting Hepatic Stellate Cell Activation by Blocking Wnt/β-Catenin Signaling Pathway in Mice Human amniotic mesenchymal stem cells (hAMSCs) were transplanted into carbon tetrachloride (CCl4)-induced liver fibrosis mice via tail vein, and the effects of hAMSCs on hepatic fibrosis were assessed. [Stem Cell Research & Therapy] Full Article Human Amniotic Fluid Mesenchymal Stem Cells Attenuate Pancreatic Cancer Cell Proliferation and Tumor Growth in an Orthotopic Xenograft Mouse Model Investigators demonstrated that human amniotic fluid mesenchymal stem cells strongly inhibit pancreatic ductal adenocarcinoma cell proliferation, tumor growth and invasion, possibly by altering cell cycle arrest and matrix metallopeptidase 7 signaling-triggered epithelial-mesenchymal transition. [Stem Cell Research & Therapy] Full Article Hyperthermia Increases HSP Production in Human PDMCs by Stimulating ROS Formation, p38 MAPK and Akt Signaling, and Increasing HSF1 Activity Scientists demonstrated that heat shock acts via reactive oxygen species (ROS) to activate p38 MAPK and Akt signaling, which subsequently activates heat shock factor 1 (HSF1), leading to HSP activation and contributing to the protective role of hPDMCs. [Stem Cell Research & Therapy] Full Article Tanshinone IIA Increased Amniotic Fluid Volume Through Down-Regulating Placental AQPs Expression via Inhibiting the Activity of GSK-3β The authors showed that compared with the women with normal amniotic fluid volume, placental Placental aquaporins 1 (AQP1), AQP3, AQP8, and AQP9 protein expressions were decreased in women with idiopathic oligohydramnios. [Cell and Tissue Research] Abstract Human Placenta Mesenchymal Stem Cell-Derived Exosome Shuttling MicroRNA-130b-3p from Gestational Diabetes Mellitus Patients Targets ICAM-1 and Perturbs Human Umbilical Vein Endothelial Cell Angiogenesis Human placenta mesenchymal stem cells from gestational diabetes mellitus patients derived exosomes shuttling miR-130b-3p repressed proliferation, migration, and angiogenesis of human umbilical vein endothelial cells by regulating ICAM-1 expression. [Acta Diabetologica] Abstract REVIEWS Potential and Challenges of Placenta-Derived Decidua Stromal Cell Therapy in Inflammation-Associated Disorders The authors present the decidual stromal cells functions in creating the anti-inflammatory environment, their immunomodulatory effects, and their advantages over mesenchymal stromal cells. [Human Immunology] Abstract INDUSTRY AND POLICY NEWS Gamida Cell Completes Rolling Biologics License Application Submission to the FDA for Omidubicel Gamida Cell Ltd. announced completion of the rolling Biologics License Application submission to the U.S. FDA for omidubicel for the treatment of patients with blood cancers in need of an allogenic hematopoietic stem cell transplant. [Gamida Cell, Ltd.] Press Release FEATURED EVENT Danish Stem Cell Society (DASCS) 2022 September 19 – 20, 2022 Vejle, Denmark > See All Events JOB OPPORTUNITIES Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism Van Andel Institute – Grand Rapids, Michigan, United States Postdoctoral Position – Computational Biology Harvard Medical School – Boston, Massachusetts, United States Tenure Track Faculty Position – Cell Signaling New York University College of Dentistry – New York, New York, United States Postdoctoral Fellow – Microenvironment and Signaling Albert Einstein College of Medicine – New York, New York, United States Scientist – Fetal Cells in Maternal Blood Luna Genetics, Inc. – Houston, Texas, United States > See All Jobs Brought to you by Science News Umbilical & Placental Cell News Archives Contact Us