Umbilical & Placental Cell News Volume 14.23 | Jun 23 2022

    By
    lbeveridge
    -
    0
    114







    2022-06-23 | UPCN 14.23


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 14.23 – 23 June, 2022
    TOP STORY

    Intravenously Transplanted Mesenchymal Stromal Cells: A New Endocrine Reservoir for Cardioprotection

    MSCs were isolated from human placenta tissue, and DF-MSCs or Gluc-MSCs were generated by transduced with firefly luciferase/enhanced green fluorescence protein or Gaussia luciferase lactadherin fusion protein.
    [Stem Cell Research & Therapy]

    Full Article


    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Not Only Ameliorate Blood Glucose but also Protect Vascular Endothelium from Diabetic Damage through a Paracrine Mechanism Mediated by MAPK/ERK Signaling

    Human umbilical cord-derived MSCs not only ameliorated blood glucose but also protected vascular endothelium from diabetic damage, in which MAPK/ERK signaling mediated its molecular mechanism of paracrine action.
    [Stem Cell Research & Therapy]

    Full Article

    A Long-Term Anti-Inflammation Markedly Alleviated High-Fat Diet-Induced Obesity by Repeated Administrations of Overexpressing IL10 Human Umbilical Cord-Derived Mesenchymal Stromal Cells

    Investigators explored whether long-term inhibition of inflammation could successfully alleviate high-fat diet-induced obesity.
    [Stem Cell Research & Therapy]

    Full Article

    Mice Lacking DCAF2 in Placenta Die at the Gastrulation Stage

    To clarify the function of DCAF2 in vivo, scientists used Cre recombinase driven by the Elf5 promoter to generate knockout mouse model that was specifically deleted Dcaf2 in the trophoblast lineage (Elf5-Cre; Dcaf2fl/fl, Dcaf2 cKO).
    [Cell and Tissue Research]

    Abstract

    Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Diffuse Alveolar Hemorrhage Associated with Systemic Lupus Erythematosus in Mice by Promoting M2 Macrophage Polarization via the microRNA-146a-5p/NOTCH1 Axis

    Human umbilical cord mesenchymal stem cell (HUCMSC)-derived exosomes diminished NOTCH1 expression to accelerate M2 macrophage polarization via delivery of miR-146a-5p, thus alleviating systemic lupus erythematosus-associated diffuse alveolar hemorrhage in mice.
    [Immunological Investigations]

    Abstract

    The Downregulation of miR-22 and miR-372 May Contribute to Gestational Diabetes Mellitus through Regulating Glucose Metabolism via the PI3K/AKT/GLUT4 Pathway

    Researchers highlighted that miR-22 and miR-372 could improve glucose metabolic disorders in gestational diabetes mellitus (GDM) and might serve as diagnostic biomarkers for GDM as well as promising therapeutic targets for the treatment of this condition.
    [Journal of Clinical Laboratory Analysis]

    Full Article

    View tips on how to organize your lab bench space.
    REVIEWS

    Mesenchymal Stromal/Stem Cells Spheroid Culture Effect on the Therapeutic Efficacy of These Cells and Their Exosomes: A New Strategy to Overcome Cell Therapy Limitations

    Due to the novelty of the field of using 3D culture MSCs-derived exosomes, examination of their properties and the results of their therapeutic application can increase our view of this field.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Aziyo Biologics Appoints Dr. C. Randal Mills as Interim President and CEO

    Aziyo Biologics, Inc., a commercial-stage regenerative medicine company focused on creating the next generation of differentiated products and improving outcomes in patients undergoing surgery, announced Aziyo co-founder C. Randal Mills, Ph.D., has been appointed interim president and CEO.
    [Aziyo Biologics, Inc.]

    Press Release

    FEATURED EVENT

    Cell Bio 2022

    December 3-7, 2022
    Washington, DC, United States

    > See All Events

    JOB OPPORTUNITIES

    Scientist – Fetal Cells in Maternal Blood

    Luna Genetics, Inc. – Houston, Texas, United States

    Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism 

    Van Andel Institute – Grand Rapids, Michigan, United States

    Tenure Track Faculty Position – Cell Signaling

    New York University College of Dentistry – New York, New York, United States

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    Postdoctoral Position – Computational Neurobiology

    Flanders Institute for Biotechnology – Antwerp, Belgium

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter