Umbilical & Placental Cell News Volume 14.25 | Jul 7 2022

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    2022-07-07 | UPCN 14.25


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    Vol. 14.25 – 7 July, 2022
    TOP STORY

    Maternal Immune Response and Placental Antibody Transfer after COVID-19 Vaccination across Trimester and Platforms

    Investigators characterized the antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 vaccination in 158 pregnant individuals and evaluate transplacental antibody transfer by profiling maternal and umbilical cord blood in 175 maternal-neonatal dyads.
    [Nature Communications]

    Full Article
    Cell Preparation For Crossmatch Assays
    PUBLICATIONSRanked by the impact factor of the journal

    Transforming Growth Factor-β Signaling Governs the Differentiation Program of Extravillous Trophoblasts in the Developing Human Placenta

    Comparative gene expression analyses of HLA-G–purified extravillous trophoblasts (EVTs), isolated from donor-matched placenta, decidua, and trophoblast organoids, revealed biological processes and signaling pathways governing EVT development.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Engineering Bioactive Nanoparticles to Rejuvenate Vascular Progenitor Cells

    Scientists reported a strategy to rejuvenate circulating vascular progenitor cells by conjugation of drug-loaded liposomal nanoparticles directly to the surface of gestational diabetes mellitus-exposed endothelial colony-forming cells.
    [Communications Biology]

    Full Article

    MicroRNA-206 Down-Regulated Human Umbilical Cord Mesenchymal Stem Cells Alleviate Cognitive Decline in D-Galactose-Induced Aging Mice

    After daily subcutaneous injection of D-gal (500 mg/kg/d) for 8 weeks, 17-week-old male C57BL/6 J mice were stem cells transplanted by lateral ventricular localization injection.
    [Cell Death Discovery]

    Full Article

    Regionally Distinct Trophoblast Regulate Barrier Function and Invasion in the Human Placenta

    Researchers used single cell RNA sequencing to compare the cell types and molecular programs between these two regions in the second trimester human placenta.
    [Developmental Biology]

    Abstract

    CircRNA, lncRNA, and mRNA Profiles of Umbilical Cord Blood Exosomes From Preterm Newborns Showing Bronchopulmonary Dysplasia

    Scientists investigated the therapeutic role of exosomes in bronchopulmonary dysplasia.
    [European Journal of Pediatrics]

    Full Article

    Dr. Daniel Dever, describes a CRISPR-Cas9-based protocol for gene editing hematopoietic stem cells in this on-demand webinar.
    REVIEWS

    Translating MSC Therapy in the Age of Obesity

    Investigators look to cancer immunotherapy as a model for the challenges mesenchymal stem cells may face in obese environments.
    [Frontiers in Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Getting Tougher on Birth Tissue Companies

    The FDA may be getting tougher on birth tissue injection companies, experts in stem cells and regenerative medicine said.
    [MedPage Today, LLC]

    Press Release
    FEATURED EVENT

    Advances in Therapeutic Applications of Stem Cells

    December 8 – 10, 2022
    Los Angeles, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Neural Stem Cells

    University of Rochester Medical Center – Rochester, New York, United States

    Senior Research Assistant – Umbilical Vein Endothelial Cells

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Scientist – Cardiovascular Magnetic

    Boston Children’s Hospital – Boston, Massachusetts , United States

    Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism 

    Van Andel Institute – Grand Rapids, Michigan, United States

    Postdoctoral Position – Computational Neurobiology

    Flanders Institute for Biotechnology – Antwerp, Belgium

    > See All Jobs

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