Umbilical & Placental Cell News Volume 14.30 | Aug 4 2022

August 4, 2022

105

2022-08-04 | UPCN 14.30

Umbilical-and-Placental-Cell-News-email-header (1)

Vol. 14.30 – 4 August, 2022

TOP STORY

SOX9 Reprograms Endothelial Cells by Altering the Chromatin Landscape

Using human umbilical vein endothelial cells (HUVECs), scientists showed that SOX9 expression alone was sufficient to activate mesenchymal genes and steer endothelial cells towards a mesenchymal fate.
[Nucleic Acids Research]

Full Article Graphical Abstract

PUBLICATIONSRanked by the impact factor of the journal

Co-Culture Pellet of Human Wharton’s Jelly Mesenchymal Stem Cells and Rat Costal Chondrocytes as a Candidate for Articular Cartilage Regeneration: In Vitro and In Vivo Study

Researchers directly co-cultured rat costal chondrocytes and evaluated human Wharton’s jelly MSCs cells as a candidate to regenerate articular cartilage.
[Stem Cell Research & Therapy]

Full Article

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-335-5p Attenuates the Inflammation and Tubular Epithelial–Myofibroblast Transdifferentiation of Renal Tubular Epithelial Cells by Reducing ADAM19 Protein Levels

HK-2, a human RTEC line, was co-treated with transforming growth factor -β1 and human umbilical cord MSC-derived exosomes.
[Stem Cell Research & Therapy]

Full Article

Human Umbilical Cord Mesenchymal Stem Cells Derived Extracellular Vesicles Regulate Acquired Immune Response of Lupus Mouse In Vitro

Scientists investigated whether human umbilical cord MSC-derived extracellular vesicles could regulate abnormal immune responses of T cells or B cells in systemic lupus erythematosus.
[Scientific Reports]

Full Article

Decreased Expression of Hypoxia-Inducible Factor 1α (HIF-1α) in Cord Blood Monocytes under Anoxia

The effect of low oxygen partial pressure on HIF-1α expression and its targets phagocytosis, reactive oxygen species production, and vascular endothelial growth factor secretion was compared in vitro between immune cells from adult peripheral blood and cord blood using anoxia.
[Pediatric Research]

Full Article

Effect of Cell Derived Matrices on Growth and Differentiation of Human Wharton’s Jelly Derived Mesenchymal Stem Cells

Investigators tested if the growth of human Wharton’s jelly derived MSCs could be enhanced when cultured on their own cell derived matrices.
[Cell Tissues Organs]

Abstract

REVIEWS

Mesenchymal Stem Cells in Fibrotic Diseases — the Two Sides of the Same Coin

The authors discuss the two opposite roles of residential MSCs and external MSCs in fibrotic diseases, and summarize the current perspective of therapeutic mechanism of MSCs in fibrosis, through both laboratory study and clinical trials.
[Acta Pharmacologica Sinica]

Full Article

INDUSTRY AND POLICY NEWS

Orca Bio Announces the Precision-T Phase III Study Is Open and Enrolling Patients at Transplant Centers across the US

Orca Bio announced Precision-T, its pivotal Phase III study, is open, enrolling and treating patients at clinical trial sites.
[Orca Bio]

Press Release

FEATURED EVENT

Umbilical & Placental Cell News Volume 14.30 | Aug 4 2022

SOX9 Reprograms Endothelial Cells by Altering the Chromatin Landscape

Co-Culture Pellet of Human Wharton’s Jelly Mesenchymal Stem Cells and Rat Costal Chondrocytes as a Candidate for Articular Cartilage Regeneration: In Vitro and In Vivo Study

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-335-5p Attenuates the Inflammation and Tubular Epithelial–Myofibroblast Transdifferentiation of Renal Tubular Epithelial Cells by Reducing ADAM19 Protein Levels

Human Umbilical Cord Mesenchymal Stem Cells Derived Extracellular Vesicles Regulate Acquired Immune Response of Lupus Mouse In Vitro

Decreased Expression of Hypoxia-Inducible Factor 1α (HIF-1α) in Cord Blood Monocytes under Anoxia

Effect of Cell Derived Matrices on Growth and Differentiation of Human Wharton’s Jelly Derived Mesenchymal Stem Cells

Mesenchymal Stem Cells in Fibrotic Diseases — the Two Sides of the Same Coin

Orca Bio Announces the Precision-T Phase III Study Is Open and Enrolling Patients at Transplant Centers across the US

3D Cell Culture Symposium

> See All Events

Postdoctoral Researcher – Immuno-Oncology

PhD Student – Bioinformatics

Associate Professor – Thematic Research Programs

Senior Research Assistant – Umbilical Vein Endothelial Cells

Clinical Cell Therapy Associate – Cord Blood Bank Program

> See All Jobs