Umbilical & Placental Cell News Volume 14.31 | Aug 11 2022

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    2022-08-11 | UPCN 14.31


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    Vol. 14.31 – 11 August, 2022
    TOP STORY

    Human Umbilical Cord Mesenchymal Stem Cells for Psoriasis: A Phase I/IIa, Single-Arm Study

    Investigators performed a Phase I/IIa, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs in the treatment of psoriasis and preliminarily explored the possible mechanisms.
    [Signal Transduction and Targeted Therapy]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Physiological Calcium Combined with Electrical Pacing Accelerates Maturation of Human Engineered Heart Tissue

    Researchers developed a human placental extracellular matrix-derived bioinkmeeting the requirements of 3D printing for printability and bioactivity.
    [Stem Cell Reports]

    Full Article

    Comparison of Therapeutic Effects of Mesenchymal Stem Cells from Umbilical Cord and Bone Marrow in the Treatment of Type 1 Diabetes

    Scientists comparef the therapeutic efficacy of umbilical cord-MSCs and bone marrow-MSCs in a mouse model of type 1 diabetes (T1D) as well as in patients with T1D.
    [Stem Cell Research & Therapy]

    Full Article

    A Novel Role of FoxO3a in the Migration and Invasion of Trophoblast Cells: From Metabolic Remodeling to Transcriptional Reprogramming

    Investigators explored the transcriptional and metabolic regulations of forkhead box O3a protein (FoxO3a) on the migration and invasion of early placental development.
    [Molecular Medicine]

    Full Article

    Exosomal miR-195 in hUC-MSCs Alleviates Hypoxia-Induced Damage of Trophoblast Cells through Tissue Factor Pathway Inhibitor 2

    Researchers explored the role of miR-195 in the cell therapy for the treatment of pre-eclampsia and the underlying mechanisms.
    [Current Research in Translational Medicine]

    Abstract

    Watermelon-Derived Extracellular Vesicles Influence Human Ex Vivo Placental Cell Behavior by Altering Intestinal Secretions

    Scientists investigated if dietary-derived extracellular vesicles could regulate placental function.
    [Molecular Nutrition & Food Research]

    AbstractFull Article
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    REVIEWS

    Umbilical Cord Mesenchymal Stem Cells and Breast Cancer: A Good Therapeutic Candidate or Not? A Minireview

    The authors review the influences of umbilical cord-derived MSCs on breast cancer and summarize this with a focus on the molecular mechanisms involved in its pathogenesis and treatment.
    [Molecular Biology Reports]

    Abstract
    INDUSTRY AND POLICY NEWS

    State ‘Personhood’ Laws Threaten Embryonic Stem Cell Research

    Biomedical scientists using embryonic stem cells or fetal tissue could find their studies at risk in conservative states aiming to redefine personhood after the US Supreme Court’s rollback of abortion rights.
    [Bloomberg Law]

    Press Release
    FEATURED EVENT

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    October 17 – 20
    Palermo (Sicily), Italy

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    JOB OPPORTUNITIES

    Senior Investigator – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Scientist Positions – Tissue Engineering

    Yale University – New Haven, Connecticut, United States

    Research Project Coordinator – Biology

    Dalla Lana School of Public Health – Toronto, Ontario, Canada

    Postdoctoral Researcher – Biofabrication of 3D Bone Metastasis Model

    Warsaw University of Technology – Warsaw, Poland

    Research Associate – Pluripotent Stem Cells

    The University of British Columbia – Vancouver, British Columbia, Canada

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