Umbilical & Placental Cell News Volume 14.34 | Sep 1 2022

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    2022-09-01 | UPCN 14.34


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    Vol. 14.34 – 1 September, 2022
    TOP STORY

    Pyrogallol Enhances Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells against LPS-Mediated Inflammation and Lung Injury via Activation of Nrf2/HO-1 Signaling

    Scientists investigated the mechanism by which pyrogallol increased the therapeutic efficacy of human umbilical cord MSCs against LPS-induced acute lung injury.
    [Free Radical Biology and Medicine]

    AbstractGraphical Abstract
    ON987CXN-sep-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    Epigenetic Signature of Exposure to Maternal Trypanosoma cruzi Infection in Cord Blood Cells from Uninfected Newborns

    Researchers performed an epigenome-wide association study to compare the DNA methylation patterns of umbilical cord blood cells from uninfected babies from chagasic and uninfected mothers.
    [Epigenomics]

    Abstract

    RNAi Screen Identifies MTA1 as an Epigenetic Modifier of Differentiation Commitment in Human HSPCs

    Investigators targeted global small hairpin RNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifiers of self-renewal and differentiation, and identified metastasis-associated 1 (MTA1) as a negative regulator of human HSPC propagation in vitro.
    [Experimental Hematology]

    Abstract

    Optimisation of Processing Methods to Improve Success in the Derivation of Human Multipotent Mesenchymal Stromal Cells from Cryopreserved Umbilical Cord Tissue Fragments

    Scientists described a simple, efficient, and reproducible approach for the cryopreservation of umbilical cord tissue fragments, compatible with established workflows in existing public frameworks for cord blood and tissue collection.
    [Cryobiology]

    Abstract

    Coculture of Adipose-Derived Mesenchymal Stem Cells/Macrophages on Decellularized Placental Sponge Promotes Differentiation into the Osteogenic Lineage

    Researchers investigated the potential of decellularized placental sponge as adipose-derived MSCs and macrophage coculture systems, and guiding the osteogenic differentiation of stem cells.
    [Artificial Organs]

    Abstract

    Protocol to Derive Human Trophoblast Stem Cells Directly from Primed Pluripotent Stem Cells

    Investigators presented a protocol to derive human trophoblast stem cells directly from primed human pluripotent stem cells.
    [STAR Protocols]

    Full ArticleGraphical Abstract
    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    REVIEWS

    Mesenchymal Stem Cell Therapy: A Review of Clinical Trials for Multiple Sclerosis

    The best source of mesenchymal stem cells seems to be the umbilical cord due to the easiness of extraction, the noninvasive method of collection, their higher expansion ability, and more powerful immune-modulating properties compared to other locations in the body.
    [Regenerative Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Henry Ford Health and MSU Health Sciences Funds Five Cancer Research Grants

    Henry Ford Health and Michigan State University (MSU) Health Sciences announced its funding of five cancer research grants of up to $100,000 each.
    [Michigan State University]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting on Integrated Cell Tracking in Oncohematology

    November 10 – 12, 2022
    Bordeaux, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Metabolic Regulation of Early Human Development

    University of Copenhagen – Copenhagen, Denmark

    Research Technologist – Center for Regenerative Medicine

    Harvard Stem Cell Institute – Boston, Massachusetts, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    PhD Position – Tumor Heterogeneity

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Associate Director – Management of PSC Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    > See All Jobs

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