Umbilical & Placental Cell News Volume 14.35 | Sep 8 2022

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    2022-09-08 | UPCN 14.35


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    Vol. 14.35 – 8 September, 2022
    TOP STORY

    Collagen Modulates the Biological Characteristics of WJ-MSCs in Basal and Osteoinduced Conditions

    Scientists investigated the effects of collagen on the characteristics of Wharton jelly (WJ)-MSCs associated with proliferation, surface markers, adhesion, migration, self-renewal, and differentiation capabilities through gene expression studies.
    [Stem Cell International]

    Full Article
    View tips on how to organize your lab bench space.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Erectile Dysfunction in Rats with Diabetes Mellitus through the Attenuation of Ferroptosis

    Researchers investigated the role of human umbilical cord MSCs in managing erectile function in rat models of type 1 diabetes mellitus and type 2 diabetes mellitus and compared the effects of two different injection methods.
    [Stem Cell Research & Therapy]

    Full Article

    Therapeutic Potential of Conditioned Medium Obtained from Deferoxamine Preconditioned Umbilical Cord Mesenchymal Stem Cells on Diabetic Nephropathy Model

    The authors performed a comparative evaluation of effects of normal-conditioned media (CM) and deferoxamine (DFS)-CM which were collected from normal and DFS preconditioned umbilical cord-derived MSCs on rat diabetic nephropathy model.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Prevent Acetaminophen-Induced Liver Injury in a Mouse Model unlike Human Dermal Fibroblasts

    Scientists evaluated GMP manufactured clinical grade human Wharton’s Jelly MSCs in a mouse model of N-acetyl-para-aminophenol hepatotoxicity in comparison to human dermal fibroblasts.
    [Archives of Toxicology]

    Abstract

    BML-260 Promotes the Growth of Cord Blood and Mobilized Peripheral Blood Hematopoietic Stem and Progenitor Cells with Improved Reconstitution Ability

    The authors identified and investigated 35 small molecules that target hematopoietic stem cells quiescence factors.
    [Journal of Cellular Biochemistry]

    Abstract

    UC-MSCs Seeded on Small Intestinal Submucosa to Repair the Uterine Wall Injuries

    The effectiveness of tissue engineering materials combining porcine small intestine submucosa and umbilical cord (UC) MSCs on uterine injury in female rats after full-thickness uterine resection was evaluated as a basis for clinical treatment of the postoperative uterine injury.
    [Tissue Engineering Part C-Methods]

    Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Human Umbilical Cord Blood Mononuclear Cells Transplantation for Perinatal Brain Injury

    Investigators discuss and review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury.
    [Stem Cell Research & Therapy]

    Full Article

    Umbilical Cord Blood: An Undervalued and Underutilized Resource in Allogeneic Hematopoietic Stem Cell Transplant and Novel Cell Therapy Applications

    The authors discuss the unwarranted decline in the use of umbilical cord blood as a source of donor hematopoietic stem cells for hematopoietic cell transplantation and the resulting important implications in addressing healthcare inequities.
    [Current Opinion in Hematology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Immutep Announces Investigator-Initiated Phase II Trial Evaluating LAG-3 Candidate Eftilagimod Alpha (Efti) in Soft Tissue Sarcoma

    Immutep Limited announced it has signed a Material Transfer Agreement with the Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw, Poland to enable an investigator-initiated open-label Phase II clinical trial.
    [Immutep Limited]

    Press Release
    FEATURED EVENT

    Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies

    January 22 – 25, 2022
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    JOB OPPORTUNITIES

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    Harvard Stem Cell Institute – Boston, Massachusetts, United States

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    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

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