Umbilical & Placental Cell News Volume 14.36 | Sep 15 2022

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    2022-09-15 | UPCN 14.36


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    Vol. 14.36 – 15 September, 2022
    TOP STORY

    Fetal Macrophages Assist in the Repair of Ruptured Amnion through the Induction of Epithelial-Mesenchymal Transition

    Scientists investigated repair mechanisms of the amnion, a layer of epithelial cells in the amniotic sac closest to the embryo.
    [Science Signaling]

    Abstract
    Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience
    PUBLICATIONSRanked by the impact factor of the journal

    Direct Conversion of Human Umbilical Cord Mesenchymal Stem Cells into Retinal Pigment Epithelial Cells for Treatment of Retinal Degeneration

    Investigators transdifferentiated human umbilical cord MSCs into induced retinal pigment epithelial cells using a cocktail of five transcription factors.
    [Cell Death & Disease]

    Full Article

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Experimental Colitis by Normalizing the Gut Microbiota

    Human umbilical cord-derived MSC treatment improved 2,4,6-trinitrobenzenesulfonic acid-induced colitis by increasing survival rates and relieving symptoms.
    [Stem Cell Research & Therapy]

    Full Article

    Maternal Cadmium Exposure Impairs Placental Angiogenesis in Preeclampsia through Disturbing Thyroid Hormone Receptor Signaling

    Researchers designed a study to determine the mechanism of cadmium exposure during pregnancy impaired placental angiogenesis that was associated with the occurrence of preeclampsia.
    [Ecotoxicology and Environmental Safety]

    Full Article

    3D Microfluidics-Assisted Modeling of Glucose Transport in Placental Malaria

    Trophoblasts cells and human umbilical vein endothelial cells were cultured on the opposite sides of an extracellular matrix gel in a compartmental microfluidic system, forming a physiological barrier between the co-flow tubular structure to mimic a simplified maternal–fetal interface in placental villi.
    [Scientific Reports]

    Full Article

    Autophagy Inhibition Restores CD200 Expression under IL-1β Microenvironment in Placental Mesenchymal Stem Cells of Fetal Origin and Improves Its Pulmonary Fibrosis Therapeutic Potential

    Researchers examined the efficacy of autophagy in placental MSCs of fetal origin in either IL-1β treatment or bleomycin induced pulmonary fibrosis mice model.
    [Molecular Immunology]

    Full Article

    Learn about Parkinson's Disease therapy with hESCs by watching Dr. Malin Parmar's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Emerging Roles of Mesenchymal Stem Cell Therapy in Patients with Critical Limb Ischemia

    The authors review the immunomodulatory features of MSC besides the current understanding of different sources of MSC in the angiogenic treatment of critical limb ischemia subjects and their potential applications as therapeutic agents.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    IMAC Holdings, Inc. Announces Completion of Third Cohort of Its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced it has completed the third cohort of its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic MSCs for the treatment of bradykinesia due to Parkinson’s disease.
    [IMAC Holdings, Inc. (GlobeNewswire, Inc.)]

    Press Release
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    JOB OPPORTUNITIES

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    University of California Santa Cruz – Santa Cruz, California, United States

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    Karolinska Institutet – Flemingsberg, Sweden

    Research Technologist – Center for Regenerative Medicine

    Harvard Stem Cell Institute – Boston, Massachusetts, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Fellowship – Metabolic Regulation of Early Human Development

    University of Copenhagen – Copenhagen, Denmark

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