Umbilical & Placental Cell News Volume 14.38 | Sep 29 2022

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    2022-09-29 | UPCN 14.38


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    Vol. 14.38 – 29 September, 2022
    TOP STORY

    NINJ1 Triggers Extravillous Trophoblast Cell Dysfunction through Blocking the STAT3 Signaling Pathway

    Researchers investigated the effect of nerve injury-induced protein 1 (NINJ1) on trophoblast behaviors and pregnancy loss.
    [Genes & Genomics]

    Full ArticleGraphical Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells

    Scientists presented a new strategy to establish placenta-like organoids with vascular-like structures from human-induced pluripotent stem cells in a defined 3D culture system.
    [Bioengineering & Translational Medicine]

    Full Article

    Unrelated Umbilical Cord Blood Can Improve the Prognosis of Haploidentical Hematopoietic Stem Cell Transplantation

    The authors showed that neither acute graft versus host disease (aGVHD) nor chronic GVHD was increased in the umbilical cord blood-haplo hematopoietic stem cell transplantation group, and the engraftment and infection rates were similar between the two groups.
    [Stem Cell Research & Therapy]

    Full Article

    Effects of Polycyclic Aromatic Hydrocarbons on Gestational Hormone Production in a Placental Cell Line: Application of Passive Dosing to In Vitro Tests

    Investigators studied the effects of some airborne polycyclic aromatic hydrocarbons on beta human chorionic gonadotropin and progesterone production by using a syncytial BeWo cell line as a placental model.
    [Ecotoxicology and Environmental Safety]

    Full ArticleGraphical Abstract

    Human Fetal Membrane-Mesenchymal Stromal Cells Generate Functional Spinal Motor Neurons In Vitro

    Researchers demonstrated that human fetal membrane-MSCs could give rise to spinal motor neurons, by the sequential exposure to specific factors that induced a neuralization, caudalization, and ventralization of undifferentiated cells
    [iScience]

    AbstractGraphical Abstract

    Multifaceted Characterization of the Biological and Transcriptomic Signatures of Natural Killer Cells Derived from Cord Blood and Placental Blood

    The authors took advantage of the “3IL”-based strategy for high-efficient generation of natural killer cells from umbilical cord blood and placental blood, respectively.
    [Cancer Cell International]

    Full Article

    Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies

    Scientists evaluated maternal microchimerism in umbilical cord blood (CB) from normal and preeclampsia pregnancies. DNA from CB mononuclear cells following placental delivery and maternal blood was extracted and genotyped.
    [Reproductive Sciences]

    Full Article

    Regenerative Effect of Umbilical Cord-Derived Mesenchymal Stromal Cells in a Rat Model of Established Limb Ischemia

    Investigators assessed the tissue regenerative potential of umbilical cord-derived MSCs, which could potentially be an ideal cell source, in a rat model of established ischemia.
    [Circulation Journal]

    Abstract
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    REVIEWS

    Oxidative Stress, Lipid Peroxidation and Premature Placental Senescence in Preeclampsia

    The authors summarize the current knowledge on premature placental senescence and the role of oxidative stress and lipid oxidation-derived aldehydes in this process, as well as their links with preeclampsia pathogenesis.
    [Archives of Biochemistry and Biophysics]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Oyen and Team Receive Funding to Study Placental Function

    Wellcome Leap has awarded Michelle Oyen, an associate professor of biomedical engineering at Washington University in St. Louis’ McKelvey School of Engineering, a multiyear contract to advance methods to assess placental function.
    [Washington University in St. Louis]

    Press Release
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    Karolinska Institutet – Flemingsberg, Sweden

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    Harvard Stem Cell Institute – Boston, Massachusetts, United States

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