Umbilical & Placental Cell News Volume 14.42 | Oct 27 2022

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    2022-10-27 | UPCN 14.42


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    Vol. 14.42 – 27 October, 2022
    TOP STORY

    Maternal Blood Pressure Associates with Placental DNA Methylation Both Directly and through Alterations in Cell-Type Composition

    The authors investigated the association between epigenome-wide DNA methylation patterns in the placenta and performed repeated measurements of maternal steady and pulsatile blood pressure indicators during pregnancy.
    [BMC Medicine]

    Full Article
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    Human Adipose- and Amnion-Derived Mesenchymal Stromal Cells Similarly Mitigate Osteoarthritis Progression in the Dunkin Hartley Guinea Pig

    Scientists compared the ability of intra-articularly injected adipose-derived MSCs and amnion-derived MSCs to mitigate the progression of knee OA in a small animal model of spontaneous osteoarthritis.
    [American Journal of Sports Medicine]

    Abstract

    Intra-Amniotic Mesenchymal Stem Cell Therapy Improves the Amniotic Fluid Microenvironment in Rat Spina Bifida Aperta Fetuses

    Researchers examined whether the amniotic fluid microenvironment could be improved by intra-amniotic bone marrow-derived MSC transplantation.
    [Cell Proliferation]

    Full Article

    Human Placental Hematopoietic Stem Cell-Derived Natural Killer Cells (CYNK) Recognize and Eliminate Influenza a Virus-Infected Cells

    Scientists investigated the antiviral activity of CYNK, human placental hematopoietic stem cell-derived natural killer cells, against Influenza A virus infection in vitro.
    [Frontiers in Immunology]

    Full Article

    Co-Alterations of Circadian Clock Gene Transcripts in Human Placenta in Preeclampsia

    Investigators examined the associations of 17 core circadian gene transcripts in placenta with preeclampsia (PE) vs. non-PE using two independent gene expression datasets.
    [Scientific Reports]

    Full Article

    Umbilical Cord Mesenchymal Stem Cells Seeded on Small Intestinal Submucosa to Repair the Uterine Wall Injuries

    The effectiveness of tissue engineering materials combining porcine small intestine submucosa and umbilical cord-MSCs on uterine injury in female rats after full-thickness uterine resection was evaluated.
    [Tissue Engineering Part C-Methods]

    Abstract
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    REVIEWS

    Matrix Metalloproteinases in Preterm Prelabor Rupture of Membranes in the Setting of Chorioamnionitis: A Scoping Review

    The authors address the question of how matrix metalloproteinase activity is associated with preterm prelabor rupture of membranes, particularly their induction due to sterile or nonsterile chorioamnionitis.
    [American Journal of Reproductive Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Amniotics Granted US Patent for Its Oncology Program AMNI-NK003

    Amniotics announced that the US Patent and Trademark Office has approved a patent application that supports the company’s anti-cancer platform AMNI-NK003.
    [Amniotics AB]

    Press Release
    FEATURED EVENT

    Type 2 Immunity in Homeostasis and Disease (2nd Edition)

    December 12 – 13, 2022
    Ghent, Belgium

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    JOB OPPORTUNITIES

    Next Generation Fellowship – Placenta and Early Development

    University of Cambridge – Cambridge, England, United Kingdom

    Research Associate – Tissue Injury and Repair

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Computational Biology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Postdoctoral Fellow and Research Associate – Obstetrics and Gynecology

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Manager – Laboratory Services

    STEMCELL Technologies – Vancouver, British Columbia, Canada

    > See All Jobs

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