 | | Vol. 14.43 – 3 November, 2022 |
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| To establish a paradigm for multiplexed gene editing in primary human cord blood-derived hematopoietic stem and progenitor cells, investigators used co-delivery of lentiviral sgRNA vectors, together with Cas9 mRNA, to simultaneously edit two genetic loci.
[Blood Cancer Journal] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified the mechanism by which human amniotic epithelial cells (hAECs) exerted their anti-cancer effects. They showed that vaccination with live hAEC conferred effective protection against murine colon cancer and melanoma but not against breast cancer.
[Cancer Cell International] |
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| Researchers investigated the appropriate condition of primming human amniotic epithelial cells (hAECs) with paclitaxel as a dual therapeutic approach consisting of inherent anticancer features of hAECs and loaded paclitaxel.
[Scientific Reports] |
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| Scientists investigated the impact of umbilical cord blood co-infusion on graft-versus-host disease in pediatric patients receiving haploidentical hematopoietic stem cell transplantation for severe aplastic anemia.
[Therapeutic Advances in Hematology] |
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| Researchers evaluated the therapeutic efficacy of human umbilical cord MSCs in a diabetic foot ulcer rat model. Wound healing was evaluated macroscopically every three days. In addition, they measured growth factors and specific proteins, matrix metalloproteinases-9 (MMP-9) and MMP-8.
[Stem Cells and Development] |
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| The authors investigated the mechanism by which human amniotic MSCs transplantation promoted endometrial regeneration.
[Cell Biology International] |
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| Investigators review recently published data on MSC administration for the treatment of pulmonary fibrosis to provide insights into the therapeutic impact of MSC delivery procedures and sources.
[DNA and Cell Biology] |
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| For the next 5 years, the National Science Foundation (NSF) will no longer require universities and other organizations to cover 30% of an award from its major research instrumentation program, which funds new equipment.
[ScienceInsider] |
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| December 7 – 9, 2022
Geneva, Switzerland |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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