Umbilical & Placental Cell News Volume 14.47 | Dec 1 2022

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    2022-12-01 | UPCN 14.47


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 14.47 – 1 December, 2022
    TOP STORY

    Preparation of Single-Cell Suspensions from the Human Placenta

    Researchers described a protocol for the preparation of high-quality single-cell suspensions from human placental tissues—namely, the basal plate, placental villi, and chorioamniotic membranes.
    [Nature Protocols]

    Full Article
    Explore this validated protocol for the gene-editing of Human CD34+ Hematopoietic Stem and Progenitor Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    The Multifaceted Role of GCM1 during Trophoblast Differentiation in the Human Placenta

    Human trophoblast stem cells were used to corroborate the role of glial cells missing-1 (GCM1) in syncytiotrophoblast formation and uncover its critical role in extravillous trophoblast development.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Small Extracellular Vesicles Derived from Nrf2-Overexpressing Human Amniotic Mesenchymal Stem Cells Protect against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting NLRP3

    Scientists tested whether small extracellular vesicles derived from Nrf2-overexpressing human amniotic mesenchymal stem cells could protect against acute lung injury.
    [Biology Direct]

    Full Article

    MiR-141–3p Promotes Hypoxia-Induced Autophagy in Human Placental Trophoblast Cells

    The authors investigated the role of miR-141–3p in autophagy induced by hypoxia in human placental trophoblast cells. They found that hypoxia induced autophagy in trophoblast cells and dramatically elevated the expression of miR-141–3p.
    [Reproductive Biology]

    Full Article

    Effects of Glucose on the Proliferation of Human Umbilical Cord Blood Hematopoietic Stem Cells

    Scientists demonstrated the relationship between glucose and the activation of the NLR family of pyrin domain-containing 3 inflammasome.
    [Cell and Tissue Banking]

    Abstract

    Comparison of Human Acellular Amniotic Membranes with Acellular Amniotic Membranes Pretreated with MPLA for Repair of Fascia in Rats

    Researchers compared the effectiveness of amniotic membrane and amniotic membrane pretreated with monophosphoryl lipid A (MPLA) for repairing the fascia of the abdomen with tension sutures.
    [Cell and Tissue Banking]

    Abstract

    Regulation of the Placental Growth Factor Mediated by Sumoylation and Expression of miR-652-3p in Pregnant Women with Early-Onset Preeclampsia

    Investigators studied regulation of the expression of placental growth factor that play an important role in the trophoblast cells functions and reduced production of which by the placenta is associated with gestational complications.
    [Bulletin of Experimental Biology and Medicine]

    Abstract
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    REVIEWS

    Accessing the Human Trophoblast Stem Cell State from Pluripotent and Somatic Cells

    The authors review the biological and molecular properties that define authentic human trophoblast stem cells (hTSCs), the trophoblast potential of distinct pluripotent states, and methods for inducing hTSCs in somatic cells by direct reprogramming.
    [Cellular and Molecular Life Sciences]

    Full Article

    Clinical Outcomes of Umbilical Cord Blood Transplantation Utilizing Ex Vivo Expansion: A Systematic Review and Meta-Analysis of Controlled Studies

    Scientists indicate that transplanting umbilical cord blood following ex vivo expansion can accelerate initial engraftment.
    [Transplantation and Cellular Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    Americord® Announces Genomic Testing Partnership with Veritas Genetics

    Americord Registry® has partnered with Veritas Genetics to develop and offer newborn and maternal whole-genome screening to Americord families.
    [Americord Registry® (Newsmatics, Inc.)]

    Press Release
    FEATURED EVENT

    Organoids as Models of Development and Disease, and Their Impact on Drug Discovery

    February 5 – 8, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Lead Associate – Clinical Trials

    Takeda – Boston, Massachusetts, United States

    Professor – Experimental Hematology

    RWTH Aachen University – Aachen, Germany

    Postdoctoral Fellow – Cancer/Stem Cell Biology

    City of Hope – Los Angeles, California, United States

    Postdoctoral Research Associate – Human Umbilical Cord Blood

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Postdoctoral Position – Transcription in Hematopoiesis and Leukemia

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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