Umbilical & Placental Cell News Volume 14.48 | Dec 8 2022

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    2022-12-08 | UPCN 14.48


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 14.48 – 8 December, 2022
    TOP STORY

    Mouse Placenta Fetal Macrophages Arise from Endothelial Cells outside the Placenta

    Using a new Hoxa13Cre allele that labeled all placental endothelial cells, investigators demonstrated that mouse placental fetal macrophages did not arise from placental endothelium.
    [Developmental Cell]

    Abstract
    Explore this validated protocol for the gene-editing of Human CD34+ Hematopoietic Stem and Progenitor Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Transient Regulation of RNA Methylation in Human Hematopoietic Stem Cells Promotes Their Homing and Engraftment

    Scientists demonstrated that inhibition of RNA decay by regulation of RNA methylation enhanced the expression of the homing receptor chemokine C-X-C receptor-4 in HSCs.
    [Leukemia]

    Full Article

    Human Placental Barrier-Brain Organoid-on-a-Chip for Modeling Maternal PM2.5 Exposure

    Researchers constructed a placental barrier-brain organoid-on-a-chip model, which enabled them to investigate the effects of maternal PM2.5 exposure on the human fetal system including the placental barrier and fetal brain.
    [Science of the Total Environment]

    AbstractGraphical Abstract

    Cord Blood Transplantation for Nonmalignant Disorders: Early Functional Immunity and High Survival

    The authors evaluated the two-year overall survival after umbilical cord blood transplantation in patients with non-malignant disorders enrolled on a prospective clinical trial using either 5/6 or 6/6 umbilical cord blood as cell source.
    [Blood Advances]

    Abstract

    Time Course and Mechanistic Analysis of Human Umbilical Cord Perivascular Cell Mitigation of Lipopolysaccharide-Induced Systemic and Neurological Inflammation

    Researchers evaluated the time course and mechanisms by which human umbilical cord perivascular cells mitigatef lipopolysaccharide-induced systemic and neurological inflammation in immunocompetent mice.
    [Cytotherapy]

    Abstract

    Different Probiotic Strains Alter Human Cord Blood Monocyte Responses

    Scientists investigated the effect of probiotics on the functions of neonatal monocytes in an in vitro model using three different strains and mononuclear cells isolated from cord blood.
    [Pediatric Research]

    Full Article
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    REVIEWS

    MSC Based Gene Delivery Methods and Strategies Improve the Therapeutic Efficacy of Neurological Diseases

    Investigators focus on gene transport technologies for engineering MSCs and the application of strategies for selecting optimal delivery genes.
    [Bioactive Materials]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Postdoc Union Reaches Tentative Agreement with University of California

    After weeks of strikes and negotiating involving thousands of early-career researchers across the University of California (UC) system, the union representing UC postdocs and academic researchers announced it has reached a tentative agreement with administrators.
    [Science Careers]

    Press Release
    FEATURED EVENT

    DDR Inhibitors Summit 2023

    January 24 – 26, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Positions – Biomedical Sciences

    Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany

    Postdoctoral Scientist – Genomic Informatics

    University of Oxford – Oxford, England, United Kingdom

    Lead Associate – Clinical Trials

    Takeda – Boston, Massachusetts, United States

    Professor – Experimental Hematology

    RWTH Aachen University – Aachen, Germany

    Postdoctoral Fellow – Cancer/Stem Cell Biology

    City of Hope – Los Angeles, California, United States

    > See All Jobs

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