Umbilical & Placental Cell News Volume 14.49 | Dec 15 2022

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    2022-12-15 | UPCN 14.49


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    Vol. 14.49 – 15 December, 2022
    TOP STORY

    Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells

    Researchers aimed to determine the potential of cardiomyogenic transcription factors in differentiating human umbilical cord-derived MSCs into cardiac-like cells in vitro.
    [Alternatives to Laboratory Animals]

    Abstract
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    Single-Cell and Spatial Transcriptomics Decodes Wharton’s Jelly-Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures

    The characteristics of Wharton’s jelly MSCs were systematically analyzed by single-cell and spatial transcriptome sequencing. Additionally, the biofunctional-type selected MSCs selected exhibited promising wound repair properties.
    [Advanced Science]

    Full Article

    Temporal Molecular Program of Human Hematopoietic Stem and Progenitor Cells after Birth

    Researchers reported a transcriptional census of human bone-marrow-derived hematopoietic stem and progenitor cells from the neonate, infant, child, adult, and aging stages, showing two subpopulations of multipotent progenitors separated by CD52 expression.
    [Developmental Cell]

    AbstractGraphical Abstract

    Effect of Umbilical Cord Essential and Toxic Elements, Thyroid Levels, and Vitamin D on Childhood Development

    Scientists evaluated multiple associations between umbilical cord essential and toxic elements, thyroid levels, and vitamin D on childhood development.
    [Biomedicine & Pharmacotherapy]

    Full Article

    Long Term Follow-Up after Hematopoietic Stem Cell Transplantation for Mucopolysaccharidosis Type I-H: A Retrospective Study of 51 Patients

    Investigators showcased results that provided a long-term assessment of hematopoietic stem cell transplantation efficacy in mucopolysaccharidosis type I-H.
    [Bone Marrow Transplantation]

    Full Article

    An Efficient Human Stem Cells Derived Cardiotoxicity Testing Platform for Testing Oncotherapeutic Analogues of Quercetin and Cinnamic Acid

    Scientists evaluated the cardiotoxic effect of synthesized derivatives of oncotherapeutics, quercetin, and cinnamic acid using human Wharton’s jelly MSCs-derived cardiomyocytes against known cardiotoxic oncologic drugs.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Vitiligo: An Immune Disease and Its Emerging Mesenchymal Stem Cell Therapy Paradigm

    Investigators summarize the currently available knowledge regarding the immunopathogenic mechanisms involved in vitiligo and the progress achieved in MSC-based therapy.
    [Transplant Immunology]

    Abstract

    The Epidermal Growth Factor Receptor in Healthy Pregnancy and Preeclampsia

    The authors consider the evidence for the possibility that the endothelial dysfunction observed in preeclampsia might in some cases result from an elevation of endothelial EGFR.
    [Journal Of Molecular Endocrinology]

    Full Article
    INDUSTRY AND POLICY NEWS

    NIH Plans Grant-Review Overhaul to Reduce Bias

    The US National Institutes of Health (NIH) has released a tentative plan to change how its research grant applications are scored, with the aim of reducing bias and lowering the burden on reviewers.
    [Nature]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Pediatric Hematologic Malignancies

    February 19 – 22, 2023
    New Orleans, Louisiana, United States

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Life Sciences

    Westlake University – Hangzhou, China

    Postdoctoral Researcher – Cancer Biology

    Flanders Institute for Biotechnology – Leuven, Belgium

    Senior Research Assistant – Genitourinary Medical Oncology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    PhD Positions – Biomedical Sciences

    Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany

    Postdoctoral Scientist – Genomic Informatics

    University of Oxford – Oxford, England, United Kingdom

    > See All Jobs

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