Umbilical & Placental Cell News Volume 15.00 | Jan 5 2023

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    2023-01-05 | UPCN 15.00


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    Vol.15.00 – 5 January, 2023
    TOP STORY

    AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells

    Scientists investigated the effects of pharmaceutical activation of AMPK, an essential regulator of energy metabolism, on mitochondrial programming of Wharton’s Jelly MSCs from women with diabetes during pregnancy.
    [Stem Cells and Development]

    Abstract
    Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells Promote Osteogenesis through the AKT Signaling Pathway in Postmenopausal Osteoporosis

    The osteogenesis effect was detected using ALP staining, alizarin red staining, and q-PCR. In vivo, the effects of exosomes derived from human umbilical cord mesenchymal stem cells were evaluated using HE staining, IHC staining and Masson staining.
    [Aging-Us]

    Full Article

    Perturbation of Placental Protein Glycosylation by Endoplasmic Reticulum Stress Promotes Maladaptation of Maternal Hepatic Glucose Metabolism

    Using mouse placental explants, researchers showed endoplasmic reticulum stress promoted secretion of mis-glycosylated glycoproteins.
    [Iscience]

    Full ArticleGraphical Abstract

    Umbilical Cord Mesenchymal-Stem-Cell-Derived Nanovesicles as a Novel Strategy to Promote Wound Healing in Diabetes

    Investigators constructed a method to produce umbilical cord mesenchymal stem cell-derived nanovesicles (UCMSC-NV) by serial extrusion through filters, and investigated the effects of UCMSC-NV on wound healing in vivo and in vitro, as well as the potential mechanisms.
    [Nano Select]

    Full Article

    Combination Therapy with Human Amniotic Epithelial Cells and Hyaluronic Acid Promotes Immune Balance Recovery in Type 1 Diabetic Rats through Local Engraftment

    Using pancreatic subcapsular transplantation, engraftment of human amniotic epithelial cells and hyaluronic acid in streptozotocin-induced type 1 diabetes mellitus rats showed potent anti-diabetic activity.
    [Scandinavian Journal Of Immunology]

    Abstract

    Highly Expressed FYN Promotes the Progression of Placenta Accreta by Activating STAT3, p38, and JNK Signaling Pathways

    High-throughput sequencing results showed that FYN was highly expressed in the placental accreta position in the placenta accreta group and was a key regulator of cell invasion and migration.
    [Acta Histochemica]

    Abstract

    Webinar: Bone Marrow Skeletal Progenitors and Bone Diseases
    REVIEWS

    Origins of Abnormal Placentation: Why Maternal Veins Must Not Be Forgotten

    The author makes the case for intervillous space congestion as an unexplored trigger for inadequate spiral artery dilatation during the placentation process, eventually leading to abnormal systemic circulatory dysfunctions.
    [American Journal Of Obstetrics And Gynecology]

    Abstract

    The Therapeutic Potential of Human Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Premature Ovarian Failure

    To summarize all the theoretical frameworks for additional research and clinical trials, this review article highlights all the results, pros, and cons of the human umbilical cord mesenchymal stem cells used to treat premature ovarian failure.
    [Stem Cell Reviews And Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    STEMCELL Technologies President and CEO Dr. Allen Eaves Appointed to the Order of Canada

    STEMCELL Technologies announced that its President and CEO, Dr. Allen Eaves, has been appointed to the Order of Canada by Her Excellency the Right Honorable Mary Simon, the Governor General of Canada.
    [STEMCELL Technologies]

    Press Release
    FEATURED EVENT

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    February 21 – 23, 2023
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    JOB OPPORTUNITIES

    PhD Positions – Life Sciences and Bioinformatics

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    Takeda – Boston, Massachusetts, United States

    Faculty Positions – Life Sciences

    Westlake University – Hangzhou, China

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