Umbilical & Placental Cell News Volume 15.02 | Jan 19 2023

    By
    Bob
    -
    0
    116








    2023-01-19 | UPCN 15.02


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.02 – 19 January, 2023
    TOP STORY

    Modeling and Analyzing Single-Cell Multimodal Data with Deep Parametric Inference

    Analysis of cord blood mononuclear cells revealed that the multimodal parameter space could characterize the heterogeneity of cells more comprehensively than individual modalities.
    [Briefings In Bioinformatics]

    Abstract
    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    PUBLICATIONSRanked by the impact factor of the journal

    Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Perianal Fistula in Non-Crohn’s Cases: Clinical Trial Phase I

    Researchers evaluated the safety of MSC-derived exosomes application for complex perianal fistula. Placenta-derived MSCs were cultured and exosomes were isolated using ultracentrifugation.
    [European Journal Of Gastroenterology & Hepatology]

    Abstract

    A Placenta-on-a-Chip Model to Determine the Regulation of FKBPL and Galectin-3 in Preeclampsia

    Investigators confirmed the abnormal expression of important vascular and inflammatory proteins, FK506-binding protein-like (FKBPL) and galectin-3, in human plasma and placental tissues from women with preeclampsia and normotensive controls.
    [Cellular And Molecular Life Sciences]

    Full Article

    Combining Bone Collagen Material with hUC-MSCs for Application to Spina Bifida in a Rabbit Model

    Results showed that the combination of human umbilical cord-MSCs with collagen material had better regeneration effect than collagen material alone, and had no negative impact on the spina bifida models.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Human Wharton-Jelly Mesenchymal Stromal Cells Reversed Apoptosis and Prevented Multi-Organ Damage in a Newborn Model of Experimental Asphyxia

    Scientists investigated the effect of applying Wharton jelly MSCs isolated from the human umbilical cord tissue on a neonatal mouse model with experimental asphyxia.
    [Journal Of Obstetrics And Gynaecology]

    AbstractGraphical Abstract

    Modulatory Role of mTOR in Trophoblast Adaptive Response in the Early Stage of Placentation in Sheep

    Primary trophoblast cells from 21-day-old sheep placenta were characterized and subjected to fibroblast growth factor-2 and rapamycin treatment to study the effects on cell functionality, gene, and protein expression profiles.
    [Reproduction]

    Abstract
    Keep current with the latest in hematopoiesis research.
    REVIEWS

    Bone Marrow Mesenchymal Stem Cells’ Osteogenic Potential: Superiority or Non-Superiority to Other Sources of Mesenchymal Stem Cells?

    The authors review the specific potential of bone marrow MSCs and compare their osteogenic potential with other types of MSCs, and discuss the future directions of bone marrow MSCs as a source for cell therapy.
    [Cell and Tissue Banking]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA No Longer Needs to Require Animal Tests before Human Drug Trials

    New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
    [ScienceInsider]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2023

    April 14 – 19, 2023
    Orlando, Florida, United States

    > See All Events

    JOB OPPORTUNITIES

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

    Postdoctoral Scholar Positions – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute – Los Angeles, California, United States

    Postdoctoral Scientist Positions – Tissue Engineering and Regeneration Medicine

    Institute of Tissue Regeneration Engineering – Seoul, Korea

    Research Scientist – Cancer Molecular Imaging

    Stanford Medicine – Stanford, California, United States

    Principal Investigator – Division of Cellular and Gene Therapies

    US FDA – Silver Spring, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter