Umbilical & Placental Cell News Volume 15.03 | Jan 26 2023

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    2023-01-26 | UPCN 15.03


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.03 – 26 January, 2023
    TOP STORY

    Hemorrhage of Human Fetal Cortex Associated with SARS-CoV-2 Infection

    SARS-CoV-2 spike protein was sparsely detected within progenitors and neurons of the fetal cortex itself, but was abundant in the choroid plexus of hemorrhagic samples.The virus was also sparsely detected in placenta, amnion, and umbilical cord tissues.
    [Brain]

    Full Article
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    Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs

    The effect of exosomes derived from human amniotic MSCs on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    3D Organoid Formation and EVT Differentiation of Various Trophoblastic Cell Lines

    Scientists tested whether commonly used trophoblastic cell lines, ACH-3P, HTR-8/SVneo, and SWAN-71 were capable of self-organizing into organoids and subsequent extravillous trophoblast differentiation.
    [Placenta]

    AbstractGraphical Abstract

    Mono(2-Ethylhexyl) Phthalate Induces Transcriptomic Changes in Placental Cells Based on Concentration, Fetal Sex, and Trophoblast Cell Type

    HTR-8/SVneo and primary syncytiotrophoblast cells were exposed to three concentrations of mono(2-ethylhexyl) phthalate for 24 hours with DMSO as a vehicle control.
    [Archives Of Toxicology]

    Full Article

    Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

    Researchers co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.
    [Stem Cells]

    Abstract
    Graphical Abstract

    RGS2 Promotes Estradiol Biosynthesis by Trophoblasts during Human Pregnancy

    Scientists reported that regulator of G-protein signaling 2 (RGS2) affected estradiol levels by regulating aromatase, a rate-limiting enzyme for estradiol biosynthesis, by using human trophoblast-derived JEG-3 cells and human placental villus tissues.
    [Experimental And Molecular Medicine]

    Full Article

    A Combination of Umbilical Cord Mesenchymal Stem Cells and Monosialotetrahexosy 1 Ganglioside Alleviates Neuroinflammation in Traumatic Brain Injury

    Investigators determined the effect of neural network reconstruction after human umbilical cord MSCs combined with monosialotetrahexosy 1 ganglioside transplantation, and the effect on the neuro-inflammation and polarization of microglia in a rat model of traumatic brain injury.
    [Experimental Brain Research]

    Abstract
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    REVIEWS

    Placental Syndromes and Long-Term Risk of Hypertension

    Whether placental impairment and clinical syndromes are causes or consequences of higher blood pressure in women remains unclear. In this review ,the authors address the relationship between blood pressure and maternal health in pregnancy.
    [Journal Of Human Hypertension]

    Full Article
    INDUSTRY AND POLICY NEWS

    EU Plans Changes to Pharmaceuticals Law to Avoid Medicine Shortages

    Proposed changes to a European Union pharmaceuticals law will include stronger obligations for the supply of medicines and earlier notifications of shortages, according to the EU Health Commissioner Stella Kyriakides.
    [Reuters]

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