Umbilical & Placental Cell News Volume 15.04 | Feb 2 2023

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    2023-02-02 | UPCN 15.04


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.04 – 2 February, 2023
    TOP STORY

    Mesenchymal Stromal Cells Ameliorate Diabetes-Induced Muscle Atrophy through Exosomes by Enhancing AMPK/ULK1-Mediated Autophagy

    Researchers evaluated the efficacy and explored molecular mechanisms of human umbilical cord MSCs (hucMSCs) and hucMSC-derived exosomes on diabetes- and obesity-induced muscle atrophy.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article
    Explore this validated protocol for the gene-editing of Human CD34+ Hematopoietic Stem and Progenitor Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Developing Small-Diameter Vascular Grafts with Human Amniotic Membrane: Long-Term Evaluation of Transplantation Outcomes in a Small Animal Model

    The authors investigated the feasibility of constructing a small vascular graft from decellularized amniotic membranes (DAMs). The genipin-crosslinked DAM graft showed an improved integrated structure, prolonged stability, proper mechanical property, and superior biocompatibility.
    [Biofabrication]

    Abstract

    Interleukin-18-Primed Human Umbilical Cord-Mesenchymal Stem Cells Achieve Superior Therapeutic Efficacy for Severe Viral Pneumonia via Enhancing T Cell Immunosuppression

    Researchers selected an appropriate cytokine, IL-18, based on the special cytokine expression profile in severe pneumonia of mice induced by H1N1 virus to prime human umbilical cord-MSCs in vitro and improved the therapeutic effect of hUC-MSCs in vivo.
    [Cell Death & Disease]

    Full Article

    Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs

    The effect of exosomes derived from human amniotic MSCs on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    Role of poFUT1 and O-Fucosylation in Placental Angiogenesis

    Scientists demonstrated that protein O-fucosyltransferase 1 (poFUT1) promoted the proliferation, migration ability, and angiogenesis potential of trophoblast cells.
    [Biology of Reproduction]

    Abstract

    Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Transplantation for Patients with Decompensated Liver Cirrhosis

    Investigators evaluated the impact of human umbilical cord blood-derived MSC transplantation on long-term outcomes in patients with decompensated liver cirrhosis.
    [Journal of Gastrointestinal Surgery]

    Full Article
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    REVIEWS

    Human Umbilical Cord Mesenchymal Stem Cells: Heralding an Effective Treatment against Esophageal Cancer?

    The authors summarize evidence regarding the effects of human umbilical cord MSCs on esophageal cancer with a mechanistic insight.
    [Cell Biology International]

    Abstract
    INDUSTRY AND POLICY NEWS

    Stricter US Guidelines for ‘Gain-of-Function’ Research Are on the Way — Maybe

    A panel of experts joined a meeting of the US National Science Advisory Board of Biosecurity, discussing on issues such as how privately funded risky research would be regulated, the role of research institutions in identifying potentially dangerous research, and much more.
    [Nature]

    Press Release
    FEATURED EVENT

    3D Cell Culture 2023: Models, Applications & Translation

    April 17 – 19, 2023
    Freiburg im Breisgau, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Therapeutic Resistance, Tumor Dormancy, and Metastasis

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Postdoctoral Fellow – Fibro/Adipogenic Progenitors

    University of Florida – Gainesville, Florida, United States

    Research Faculty Position – Gynecology Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    The Ottawa Hospital – Ottawa, Ontario, Canada

    Postdoctoral Scientist – Cell Biology

    MRC National Institute for Medical Research – Cambridge, England, United Kingdom

    > See All Jobs

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