Umbilical & Placental Cell News Volume 15.08 | Mar 9 2023

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    2023-03-09 | UPCN 15.08


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    Vol. 15.08 – 9 March, 2023
    TOP STORY

    Classical Monocyte-Derived Macrophages as Therapeutic Targets of Umbilical Cord Mesenchymal Stem Cells: Comparison of Intratracheal and Intravenous Administration in a Mouse Model of Pulmonary Fibrosis

    The authors determined the changes in various immune cells, especially macrophages and monocytes, involved in the effects of MSC treatment on pulmonary fibrosis.
    [Respiratory Research]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Amnion-Derived Serum Amyloid A1 Participates in Sterile Inflammation of Fetal Membranes at Parturition

    The role of serum amyloid A1 in chemokine expression and leukocyte chemotaxis was examined in cultured human amnion tissue explants as well as primary human amnion fibroblasts.
    [Inflammation Research]

    Abstract

    Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after Allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity

    Scientists defined the effects and underlying mechanisms of human amniotic membrane-derived MSCs regulating the gut microbiota and intestinal immunity in acute graft-versus-host disease (aGVHD).
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Physiologically Relevant Culture Medium Plasmax Improves Human Placental Trophoblast Stem Cell Function

    Investigators showed that the physiological medium, Plasmaxä, with nutrient and metabolite concentrations recapitulating human plasma improved human trophoblast stem cell proliferation and differentiation compared to standard medium.
    [American Journal of Physiology-Cell Physiology]

    Abstract

    Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy to Prevent the Development of Neurodevelopmental Disorders Related to Low Birth Weight

    Scientists determined whether the systemic administration of umbilical cord-derived MSCs in the early postnatal period could attenuate neuroinflammation and thereby prevent the emergence of neurodevelopmental disorders.
    [Scientific Reports]

    Full Article

    Osteoclastogenesis of Human Peripheral Blood, Bone Marrow, and Cord Blood Monocytes

    Researchers compared monocytes from human bone marrow, peripheral blood, and umbilical cord blood and their osteoclastogenic potential by culturing them with RANKL and M-CSF for 14 days.
    [Scientific Reports]

    Full Article

    Fabrication and Multiscale Modeling of Polycaprolactone/Amniotic Membrane Electrospun Nanofiber Scaffolds for Wound Healing

    Scanning electron microscope and MTT assays showed significant cellular proliferation and viability on the proposed scaffolds, and these analyses illustrated that higher cell survival and adhesion could be achieved when scaffolds possessed a larger amount of amniotic membrane.
    [Artificial Organs]

    Abstract
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    REVIEWS

    Human Amniotic Epithelial Stem Cells: Hepatic Differentiation and Regenerative Properties in Liver Disease Treatment

    The authors review the general characteristics of the epithelial stem cells isolated from the human amniotic membrane as well as their ability to differentiate into hepatic cells.
    [Placenta]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cancer Will Cost the World $25 Trillion over Next 30 Years

    The total cost of cancer to the global economy will reach 25.2 trillion international dollars between 2020 and 2050, according to an analysis of 29 cancers across 204 countries.
    [Nature]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Leukemic Niche

    Karolinska Institute – Solna, Sweden

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    The University of Melbourne – Melbourne, Australia

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Staff Scientist – Frankfurt Cancer Institute Organoid Biobank

    The Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus – Frankfurt, Germany

    Research Faculty Position – Obstetrics and Gynecology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

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