Umbilical & Placental Cell News Volume 15.09 | Mar 16 2023

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    2023-03-15 | UPCN 15.09


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.09 – 16 March, 2023
    TOP STORY

    HIV-1 Remission and Possible Cure in a Woman after Haplo-Cord Blood Transplant

    Scientists reported the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant, cord blood cells combined with haploidentical stem cells from an adult, to treat acute myeloid leukemia.
    [Cell]

    Full ArticlePress ReleaseGraphical Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosome Suppresses Programmed Cell Death in Traumatic Brain Injury via PINK1/Parkin-Mediated Mitophagy

    The authors investigated the protective effects of human umbilical cord MSC-derived exosome in both in vivo and in vitro traumatic brain injury models.
    [CNS Neuroscience & Therapeutics]

    Full Article

    Placental Cell Type Deconvolution Reveals That Cell Proportions Drive Preeclampsia Gene Expression Differences

    Scientists generated single-cell RNA-sequencing samples for integration with existing data to create the largest deconvolution reference of 19 fetal and eight maternal cell types from placental villous tissue.
    [Communications Biology]

    Full Article

    Downregulated ETV4 Inhibits the Proliferation, Migration, and Invasion of Trophoblast Cells in Preeclampsia

    Researchers showed that ETS Variant Transcription Factor 4 (ETV4) played an essential role in the proliferation, invasion, and migration of trophoblast cells by regulating matrix metalloproteinase-2 (MMP-2) and MMP-9 and was involved in the pathogenesis of preeclampsia.
    [Reproduction]

    Abstract

    circPTK2 Promotes Proliferation, Migration, and Invasion of Trophoblast Cells through the miR-619/WNT7B Pathway in Preeclampsia

    Investigators identified the functions and mechanisms of the circPTK2/miR-619/WNT7B axis in preeclampsia progression.
    [Molecular and Cellular Biochemistry]

    Abstract

    Fetal Membranes Exhibit Similar Nutrient Transporter Expression Profiles to the Placenta

    Researchers determined nutrient transport expression in human fetal membranes (FM) and FM cells and compared expression with placental tissues and BeWo cells.
    [Placenta]

    Abstract
    Guide to everything you need to know about cell separation.
    REVIEWS

    Research Progress on the Osteogenesis-Related Regulatory Mechanisms of Human Umbilical Cord Mesenchymal Stem Cells

    Scientists discuss the osteogenesis-related regulatory mechanisms of human umbilical cord MSCs, summarize the currently known related mechanisms, and speculate on the possible signals.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Monash Awarded More than $53M through MRFF for Medical and Health Research

    The Australian Government has awarded more than $53M through the Medical Research Future Fund (MRFF) to 21 Monash researchers for research into cardiovascular disease, respiratory disease, dementia, cancer, primary health care, nutrition, and more.
    [Monash University]

    Press Release
    FEATURED EVENT

    3D Cell Culture UK

    April 25 – 26, 2023
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoc Scholarship – Proteomics and Leukemia

    Lund University – Lund, Sweden

    Postdoctoral Researcher – Leukemic Niche

    Karolinska Institute – Solna, Sweden

    Scientist – Cancer and Hematologic Disorders

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Research Faculty Position – Obstetrics and Gynecology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    > See All Jobs

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