Umbilical & Placental Cell News Volume 15.12 | Apr 6 2023

April 6, 2023

116

2023-04-06 | UPCN 15.12

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Vol. 15.12 – 6 April, 2023

TOP STORY

Primitive Hematopoiesis in the Human Placenta Gives Rise to Macrophages with Epigenetically Silenced HLA-DR

Researchers identified a population of placental erythro-myeloid progenitors in the early human placenta that had conserved features of primitive yolk sac erythro-myeloid progenitors.
[Nature Communications]

Full Article

Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Regulation of Human Trophoblast Gene Expression by Endogenous Retroviruses

The authors identified multiple endogenous retrovirus families with regulatory potential that lie close to genes with preferential expression in trophoblast.
[Nature Structural & Molecular Biology]

Full Article

Exposure of Newborns to Atmospherically Relevant Artificial Particulate Matter Induces Hematopoietic Stem Cell Senescence

Scientists investigated how exposure to atmospherically relevant artificial particulate matter of diameter < 2.5 µm affected hematopoietic stem and progenitor cells in newborns. [Journal Of Hazardous Materials]

Full Article Graphical Abstract

Evaluation of Preclinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in Ankylosing Spondylitis

Researchers used a combination of bovine proteoglycan and dimethyldioctadecylammonium to establish a mouse model of proteoglycan-induced spondylitis.
[Frontiers In Immunology]

Full Article

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Angiogenesis through Upregulation of the VWF and Flk1 Genes in Endothelial Cells

Investigators evaluated the mechanism of angiogenesis supported by exosomes derived from human umbilical cord MSCs.
[Advances in Experimental Medicine and Biology]

Abstract

Gse1, a Component of the CoREST Complex, Is Required for Placenta Development in the Mouse

Cultured trophoblast stem cells lacking Gse1 showed impaired in vitro cell differentiation into spongiotrophoblasts.
[Developmental Biology]

Abstract Graphical Abstract

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REVIEWS

Approaches to Modeling Placental Function in Preeclampsia In Vitro and In Vivo

The authors review recent developments in stem-cell-based models, organoids, and co-culture systems which recapitulate various aspects of preeclampsia.
[Journal of Endocrinology]

Abstract

INDUSTRY AND POLICY NEWS

FDA Converts to Full Approval Indication for Keytruda^® (Pembrolizumab) for Certain Adult and Pediatric Patients with Advanced Microsatellite Instability-High (Msi-H) or Mismatch Repair Deficient (dMMR) Solid Tumors

Merck announced that the US FDA has granted full approval to KEYTRUDA for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options.
[Merck]

Press Release

FEATURED EVENT

Umbilical & Placental Cell News Volume 15.12 | Apr 6 2023

Primitive Hematopoiesis in the Human Placenta Gives Rise to Macrophages with Epigenetically Silenced HLA-DR

Regulation of Human Trophoblast Gene Expression by Endogenous Retroviruses

Exposure of Newborns to Atmospherically Relevant Artificial Particulate Matter Induces Hematopoietic Stem Cell Senescence

Evaluation of Preclinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in Ankylosing Spondylitis

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Angiogenesis through Upregulation of the VWF and Flk1 Genes in Endothelial Cells

Gse1, a Component of the CoREST Complex, Is Required for Placenta Development in the Mouse

Approaches to Modeling Placental Function in Preeclampsia In Vitro and In Vivo

FDA Converts to Full Approval Indication for Keytruda^® (Pembrolizumab) for Certain Adult and Pediatric Patients with Advanced Microsatellite Instability-High (Msi-H) or Mismatch Repair Deficient (dMMR) Solid Tumors

Balancing Genome Fidelity and Plasticity

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Research Faculty Position – Placental Biology and Gynecologic Oncology

Research Fellow – Neuromuscular Disease

Director – Cardiovascular Tissue Engineering

Postdoctoral Fellowship – Cancer Research and Tumor Immunology

Research Fellow – Stem Cell Biology

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