Umbilical & Placental Cell News Volume 15.14 | Apr 20 2023

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    2023-04-20 | UPCN 15.14


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    Vol. 15.14 – 20 April, 2023
    TOP STORY

    Identifying a Dynamic Transcriptomic Landscape of the Cynomolgus Macaque Placenta during Pregnancy at Single-Cell Resolution

    The authors presented a single-cell transcriptome-wide view of the cynomolgus macaque placenta throughout gestation.
    [Developmental Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Low-Intensity Pulsed Ultrasound Promotes Mesenchymal Stem Cell Transplantation-Based Articular Cartilage Regeneration via Inhibiting the TNF Signaling Pathway

    Researchers investigated the promoting effects and mechanisms underlying low-intensity pulsed ultrasound stimulation on the chondrogenic differentiation of human umbilical cord MSCs and further evaluated its regenerative application value in articular cartilage defects in rats.
    [Stem Cell Research & Therapy]

    Full Article

    JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound by Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells

    Scientists investigated the potential effect of JAM-A on human umbilical cord-derived MSCs under diabetic environment and explored the underlying mechanism.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Albumin-Based Solution Is the Ideal Post-Thawing Suspension Medium for Cord Blood Hematopoietic Stem Cells: A Stability and Proliferative Evaluation

    Investigators evaluated the thawing and washing protocol of cord blood derived hematopoietic stem cells or the HPC, by selecting the optimal thawing solution and determining CD34+ cells’ stability over time.
    [Transfusion]

    Full Article

    Lyophilized Human Platelet Lysate as a Supplementation in the Culture of Umbilical Cord Derived Mesenchymal Stem Cells

    To increase its shelf life, human platelet lysate was lyophilized and used for culturing human umbilical cord tissue MSCs.
    [Tissue and Cell]

    Abstract

    Adipose-Derived Human Mesenchymal Stem Cells Seeded on Denuded or Stromal Sides of the Amniotic Membrane Improve Angiogenesis and Collagen Remodeling and Accelerate Healing of the Full-Thickness Wound

    Researchers investigated the feasibility and effectiveness of wound healing using decellularized human amniotic membrane (HAM) and stromal HAM in combination with adipose-derived human MSCs.
    [Acta Histochemica]

    AbstractGraphical Abstract
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    REVIEWS

    Barriers to Progress in Pregnancy Research: How Can We Break Through?

    The authors provide insight into placental model development for studying pregnancy disorders. Newer approaches include trophoblast organoids to model the developing placenta and integrated data-science approaches to study longer-term outcomes.
    [Science]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves Cell Therapy for Patients with Blood Cancers to Reduce Risk of Infection Following Stem Cell Transplantation

    The US FDA approved Omisirge, a substantially modified allogeneic cord blood-based cell therapy to quicken the recovery of neutrophils in the body and reduce the risk of infection.
    [FDA]

    Press Release
    FEATURED EVENT

    Hypoxia: From Basic Mechanisms to Emerging Therapies

    May 28 – 31, 2023
    Killarney, Ireland

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    JOB OPPORTUNITIES

    Specialist – Cell Processing

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    PhD Position – Biology and Nutrition

    Universit̩ de Lausanne РLausanne, Switzerland

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Research Faculty Position – Placental Biology and Gynecologic Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    > See All Jobs

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