Umbilical & Placental Cell News Volume 15.15 | Apr 27 2023

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    2023-04-27 | UPCN 15.15


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.15 – 27 April, 2023
    TOP STORY

    In Vitro Erythrocyte Production Using Human-Induced Pluripotent Stem Cells: Determining the Best Hematopoietic Stem Cell Sources

    Human-induced pluripotent stem cells were established from three different hematopoietic stem cell sources—peripheral blood, cord blood, and bone marrow aspirates— using episomal reprogramming vectors and differentiated into functionalred blood cells.
    [Stem Cell Research & Therapy]

    Full Article
    Explore this validated protocol for the gene-editing of Human CD34+ Hematopoietic Stem and Progenitor Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Serum- and Xeno-Free Culture of Human Umbilical Cord Perivascular Cells for Pediatric Heart Valve Tissue Engineering

    The proliferative, clonogenic, multilineage differentiation, and extracellular matrix synthesis capacities o fhuman umbilical cord perivascular cells were evaluated in a commercial serum- and xeno-free culture medium on tissue culture polystyrene and benchmarked to adult bone marrow-derived MSCs.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    MiR-26a-5p From HucMSC-Derived Extracellular Vesicles Inhibits Epithelial Mesenchymal Transition by Targeting Adam17 in Silica-Induced Lung Fibrosis

    The authors used the epithelial-mesenchymal transition (EMT) model in MLE-12 cells and observed the effects and mechanism of human umbilical cord MSCs (HucMSC)-derived extracellular vesicles inhibition of EMT.
    [Ecotoxicology And Environmental Safety]

    Full ArticleGraphical Abstract

    In Vitro Simulated Neuronal Environmental Conditions Qualify Umbilical Cord Derived Highly Potent Stem Cells for Neuronal Differentiation

    Scientists investigated the capacity of spontaneously forming stem cell spheroids from cultured Wharton’s Jelly stromal cells in regard to their neuronal differentiation potential, and compared them to undifferentiated spheroids or adherent MSCs.
    [Stem Cell Reviews And Reports]

    Full ArticleGraphical Abstract

    Heath-Related Quality of Life in Double Umbilical Cord Blood vs. Haploidentical Marrow Transplantation: a QOL Analysis Report of BMT CTN 1101

    Investigators compared longitudinal quality of life (QOL) measures between double umbilical cord blood transplants and haploidentical bone marrow transplants and investigated the association of QOL and clinical outcomes.
    [Transplantation And Cellular Therapy]

    Abstract

    Human Amniotic Mesenchymal Stem Cell-Conditioned Medium Inhibited LPS-Induced Cell Injury and Inflammation by Modulating CD14/TLR4-Mediated Signaling Pathway in Monocytes

    Researchers found that conditioned medium of human amniotic mesenchymal stem cells treatment suppressed lipopolysaccharide-induced activation of MAPK and NF-κB pathways by inhibiting CD14/TLR4 in THP-1 cells.
    [Molecular Immunology]

    Full ArticleGraphical Abstract
    Learn how to avoid jargon and use blogs and social media channels to inform the public about your science
    REVIEWS

    The Human Placenta: New Perspectives on Its Formation and Function during Early Pregnancy

    The authors review the latest research findings and their significance in the context of understanding the development of the human placenta and how associated disorders are related to common pregnancy complications.
    [Proceedings Of The Royal Society B-Biological Sciences]

    Full Article

    Hybrid Umbilical Cord Blood Banking: Literature Review

    Scientists assess different options of umbilical cord blood banking and whether hybrid banking could be a valuable alternative to the existing public and private cord blood banking models.
    [Archives Of Gynecology And Obstetrics]

    Full Article
    INDUSTRY AND POLICY NEWS

    ImmuneBridge Raises $12 Million to Source Natural Killer Cell Therapies from Umbilical Cord Blood

    The biotech startup Immune Bridge has bagged $12 million in a seed financing round to drive the development of natural killer cells that can be used in cell therapies for cancer.
    [BioPharmaReporter]

    News Article
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

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    JOB OPPORTUNITIES

    Senior Research Assistant – Laboratory

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Specialist – Cell Processing

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    PhD Position – Biology and Nutrition

    Université de Lausanne – Lausanne, Switzerland

    Research Faculty Position – Placental Biology and Gynecologic Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Director – Cardiovascular Tissue Engineering

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    > See All Jobs

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